Search Results - "Jacobs, Jelle"
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Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling
Published in PLoS genetics (01-02-2015)“…Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active…”
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2
Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice
Published in Science (American Association for the Advancement of Science) (22-11-2019)“…The Hippo signaling pathway and its two downstream effectors, the YAP and TAZ transcriptional coactivators, are drivers of tumor growth in experimental models…”
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An Ectopic Network of Transcription Factors Regulated by Hippo Signaling Drives Growth and Invasion of a Malignant Tumor Model
Published in Current biology (22-08-2016)“…Cancer cells have abnormal gene expression profiles; however, to what degree these are chaotic or driven by structured gene regulatory networks is often not…”
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4
dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis
Published in PLoS genetics (21-07-2016)“…Proper organ patterning depends on a tight coordination between cell proliferation and differentiation. The patterning of Drosophila retina occurs both very…”
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Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila
Published in Science (American Association for the Advancement of Science) (14-07-2023)“…Gene expression is controlled by the precise activation and repression of transcription. Repression is mediated by specialized transcription factors (TFs) that…”
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Robust stability analysis of an energy-efficient control in a Networked Control System with application to unmanned ground vehicles
Published in Information sciences (01-11-2021)“…•An energy-efficient event-triggered dual-rate networked control system is presented.•Kalman filtering, prediction-based and packet-based control are…”
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The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
Published in Nature genetics (01-07-2018)“…Transcriptional enhancers function as docking platforms for combinations of transcription factors (TFs) to control gene expression. How enhancer sequences…”
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Hippo Reprograms the Transcriptional Response to Ras Signaling
Published in Developmental cell (25-09-2017)“…Hyperactivating mutations in Ras signaling are hallmarks of carcinomas. Ras signaling mediates cell fate decisions as well as proliferation during development…”
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The transcription factor Grainyhead primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
Published in Nature genetics (04-06-2018)“…Transcriptional enhancers function as docking platforms for combinations of transcription factors to control gene expression. How enhancer sequences determine…”
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10
Discovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling: e1004994
Published in PLoS genetics (01-02-2015)“…Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active…”
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11
Robust stability analysis of an energy-efficient control in a Networked Control System with application to Unmanned Ground Vehicles
Published 22-01-2024“…In this paper, the robust stability and disturbance rejection performance analysis of an energy-efficient control is addressed in the framework of Networked…”
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