Search Results - "Jacobs, Jacqueline J L"

H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres by de Krijger, Inge, van der Torre, Jaco, Peuscher, Marieke H., Eder, Mathias, Jacobs, Jacqueline J. L.

“…The epigenetic environment plays an important role in DNA damage recognition and repair, both at DNA double-strand breaks and at deprotected telomeres. To…”
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OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824 by Lam, Shiu Yeung, van der Lugt, Ruben, Cerutti, Aurora, Yalçin, Zeliha, Thouin, Alexander M., Simonetta, Marco, Jacobs, Jacqueline J. L.

“…Appropriate repair of damaged DNA and the suppression of DNA damage responses at telomeres are essential to preserve genome stability. DNA damage response…”
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MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner by Paniagua, Inés, Tayeh, Zainab, Falcone, Mattia, Hernández Pérez, Santiago, Cerutti, Aurora, Jacobs, Jacqueline J. L.

“…Protection of stalled replication forks is essential to prevent genome instability, a major driving force of tumorigenesis. Several key regulators of DNA…”
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UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168 by Yalçin, Zeliha, Lam, Shiu Yeung, Peuscher, Marieke H., van der Torre, Jaco, Zhu, Sha, Iyengar, Prasanna V., Salas-Lloret, Daniel, de Krijger, Inge, Moatti, Nathalie, van der Lugt, Ruben, Falcone, Mattia, Cerutti, Aurora, Bleijerveld, Onno B., Hoekman, Liesbeth, González-Prieto, Román, Jacobs, Jacqueline J. L.

“…Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing…”
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MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair by de Krijger, Inge, Föhr, Bastian, Pérez, Santiago Hernández, Vincendeau, Estelle, Serrat, Judit, Thouin, Alexander Marc, Susvirkar, Vivek, Lescale, Chloé, Paniagua, Inés, Hoekman, Liesbeth, Kaur, Simranjeet, Altelaar, Maarten, Deriano, Ludovic, Faesen, Alex C., Jacobs, Jacqueline J. L.

“…MAD2L2 (REV7) plays an important role in DNA double-strand break repair. As a member of the shieldin complex, consisting of MAD2L2, SHLD1, SHLD2 and SHLD3, it…”
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DNA-damage response and repair activities at uncapped telomeres depend on RNF8 by Jacobs, Jacqueline J. L, Peuscher, Marieke H

“…Loss of telomere protection causes natural chromosome ends to become recognized by DNA-damage response and repair proteins. These events result in ligation of…”
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Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells by Dev, Harveer, Chiang, Ting-Wei Will, Lescale, Chloe, de Krijger, Inge, Martin, Alistair G., Pilger, Domenic, Coates, Julia, Sczaniecka-Clift, Matylda, Wei, Wenming, Ostermaier, Matthias, Herzog, Mareike, Lam, Jonathan, Shea, Abigail, Demir, Mukerrem, Wu, Qian, Yang, Fengtang, Fu, Beiyuan, Lai, Zhongwu, Balmus, Gabriel, Belotserkovskaya, Rimma, Serra, Violeta, O’Connor, Mark J., Bruna, Alejandra, Beli, Petra, Pellegrini, Luca, Caldas, Carlos, Deriano, Ludovic, Jacobs, Jacqueline J. L., Galanty, Yaron, Jackson, Stephen P.

“…BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To…”
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MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection by Boersma, Vera, Moatti, Nathalie, Segura-Bayona, Sandra, Peuscher, Marieke H., van der Torre, Jaco, Wevers, Brigitte A., Orthwein, Alexandre, Durocher, Daniel, Jacobs, Jacqueline J. L.

“…MAD2L2 regulates DNA repair at deprotected telomeres and at ionizing-radiation-induced double-stranded DNA breaks by inhibiting resection of the 5′ ends; the…”
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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus by van Lohuizen, Maarten, Jacobs, Jacqueline J. L, Kieboom, Karin, Marino, Silvia, DePinho, Ronald A

“…The bmi-1 gene was first isolated as an oncogene that cooperates with c-myc in the generation of mouse lymphomas,. We subsequently identified Bmi-1 as a…”
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PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining by Luijsterburg, Martijn S., de Krijger, Inge, Wiegant, Wouter W., Shah, Rashmi G., Smeenk, Godelieve, de Groot, Anton J.L., Pines, Alex, Vertegaal, Alfred C.O., Jacobs, Jacqueline J.L., Shah, Girish M., van Attikum, Haico

“…The response to DNA double-strand breaks (DSBs) requires alterations in chromatin structure to promote the assembly of repair complexes on broken chromosomes…”
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H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2 by Simonetta, Marco, de Krijger, Inge, Serrat, Judit, Moatti, Nathalie, Fortunato, Diogo, Hoekman, Liesbeth, Bleijerveld, Onno B, Altelaar, A F Maarten, Jacobs, Jacqueline J L

“…The main pathways for the repair of DNA double strand breaks (DSBs) are non-homologous end-joining (NHEJ) and homologous recombination directed repair (HDR)…”
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Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction by Yalçin, Zeliha, Selenz, Carolin, Jacobs, Jacqueline J L

“…Telomeres are essential nucleoprotein structures at linear chromosomes that maintain genome integrity by protecting chromosome ends from being recognized and…”
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Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1 by Itahana, Koji, Zou, Ying, Itahana, Yoko, Martinez, Jose-Luis, Beausejour, Christian, Jacobs, Jacqueline J. L., van Lohuizen, Maarten, Band, Vimla, Campisi, Judith, Dimri, Goberdhan P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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REV7: Jack of many trades by de Krijger, Inge, Boersma, Vera, Jacobs, Jacqueline J.L.

“…The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of proteins and thereby contributes to the establishment of different complexes…”
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Freedom to err: The expanding cellular functions of translesion DNA polymerases by Paniagua, Inés, Jacobs, Jacqueline J.L.

“…Translesion synthesis (TLS) DNA polymerases were originally described as error-prone enzymes involved in the bypass of DNA lesions. However, extensive research…”
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The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells by Barazas, Marco, Annunziato, Stefano, Pettitt, Stephen J., de Krijger, Inge, Ghezraoui, Hind, Roobol, Stefan J., Lutz, Catrin, Frankum, Jessica, Song, Fei Fei, Brough, Rachel, Evers, Bastiaan, Gogola, Ewa, Bhin, Jinhyuk, van de Ven, Marieke, van Gent, Dik C., Jacobs, Jacqueline J.L., Chapman, Ross, Lord, Christopher J., Jonkers, Jos, Rottenberg, Sven

“…Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in…”
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Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants by Yang, Chao, Pataskar, Abhijeet, Feng, Xiaodong, Montenegro Navarro, Jasmine, Paniagua, Inés, Jacobs, Jacqueline J L, Zaal, Esther A, Berkers, Celia R, Bleijerveld, Onno B, Agami, Reuven

“…Many types of human cancers suppress the expression of argininosuccinate synthase 1 (ASS1), a rate-limiting enzyme for arginine production. Although dependency…”
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Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control by Yalçin, Zeliha, Koot, Daniëlle, Bezstarosti, Karel, Salas-Lloret, Daniel, Bleijerveld, Onno B., Boersma, Vera, Falcone, Mattia, González-Prieto, Román, Altelaar, Maarten, Demmers, Jeroen A.A., Jacobs, Jacqueline J.L.

“…Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis…”
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Quantification of Chromosomal Aberrations in Mammalian Cells by Paniagua, Inés, Jacobs, Jacqueline

“…Maintenance of genome integrity requires efficient and faithful resolution of DNA breaks and DNA replication obstacles. Dysfunctions in any of the processes…”
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Senescence: back to telomeres by Jacobs, Jacqueline J. L.

“…The demonstration that senescence is caused by both telomere erosion and oncogene-induced accumulation of DNA damage at telomeres…”
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