Search Results - "Jacobs, Howard"

Mitochondria are physiologically maintained at close to 50 °C by Chrétien, Dominique, Bénit, Paule, Ha, Hyung-Ho, Keipert, Susanne, El-Khoury, Riyad, Chang, Young-Tae, Jastroch, Martin, Jacobs, Howard T, Rustin, Pierre, Rak, Malgorzata

“…In endothermic species, heat released as a product of metabolism ensures stable internal temperature throughout the organism, despite varying environmental…”
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
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Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation by Billingham, Leah K., Stoolman, Joshua S., Vasan, Karthik, Rodriguez, Arianne E., Poor, Taylor A., Szibor, Marten, Jacobs, Howard T., Reczek, Colleen R., Rashidi, Aida, Zhang, Peng, Miska, Jason, Chandel, Navdeep S.

“…The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been…”
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Mitochondria: great balls of fire by Jacobs, Howard T., Rustin, Pierre, Bénit, Paule, Davidi, Dan, Terzioglu, Mügen

“…Recent experimental studies indicate that mitochondria in mammalian cells are maintained at temperatures of at least 50 °C. While acknowledging the limitations…”
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A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation by Richter, Uwe, Lahtinen, Taina, Marttinen, Paula, Myöhänen, Maarit, Greco, Dario, Cannino, Giuseppe, Jacobs, Howard T., Lietzén, Niina, Nyman, Tuula A., Battersby, Brendan J.

“…Proliferating cells require coordinated gene expression between the nucleus and mitochondria in order to divide, ensuring sufficient organelle number in…”
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Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism by Jacobs, Howard T, George, Jack, Kemppainen, Esko

“…Mitochondrial functions are often considered purely from the standpoint of catabolism, but in growing cells they are mainly dedicated to anabolic processes,…”
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Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction by El-Khoury, Riyad, Dufour, Eric, Rak, Malgorzata, Ramanantsoa, Nelina, Grandchamp, Nicolas, Csaba, Zsolt, Duvillié, Bertrand, Bénit, Paule, Gallego, Jorge, Gressens, Pierre, Sarkis, Chamsy, Jacobs, Howard T, Rustin, Pierre

“…Cyanide-resistant non-phosphorylating respiration is known in mitochondria from plants, fungi, and microorganisms but is absent in mammals. It results from the…”
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Correction: Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active by Giordano, Luca, Aneja, Manish K., Sommer, Natascha, Alebrahimdehkordi, Nasim, Seraji, Alireza, Weissmann, Norbert, Rudolph, Carsten, Plank, Christian, Jacobs, Howard T., Szibor, Marten

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A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans by Lewis, Samantha C, Joers, Priit, Willcox, Smaranda, Griffith, Jack D, Jacobs, Howard T, Hyman, Bradley C

“…Mitochondrial DNA (mtDNA) encodes respiratory complex subunits essential to almost all eukaryotes; hence respiratory competence requires faithful duplication…”
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Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active by Giordano, Luca, Aneja, Manish K., Sommer, Natascha, Alebrahimdehkordi, Nasim, Seraji, Alireza, Weissmann, Norbert, Rudolph, Carsten, Plank, Christian, Jacobs, Howard T., Szibor, Marten

“…Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial…”
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Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts by Reyes, Aurelio, Kazak, Lawrence, Wood, Stuart R, Yasukawa, Takehiro, Jacobs, Howard T, Holt, Ian J

“…The observation that long tracts of RNA are associated with replicating molecules of mitochondrial DNA (mtDNA) suggests that the mitochondrial genome of…”
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Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter by Rubio-Cosials, Anna, Sydow, Jasmin F, Jiménez-Menéndez, Nereida, Fernández-Millán, Pablo, Montoya, Julio, Jacobs, Howard T, Coll, Miquel, Bernadó, Pau, Solà, Maria

“…The human mitochondrial transcription factor TFAM is essential for DNA packaging as well as transcription. X-ray analysis of TFAM in complex with a…”
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Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism by Jõers, Priit, Jacobs, Howard T

“…Mitochondrial DNA synthesis is necessary for the normal function of the organelle and for the eukaryotic organism as a whole. Here we demonstrate, using…”
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Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila by George, Jack, Jacobs, Howard T.

“…The PGC-1 transcriptional coactivators have been proposed as master regulators of mitochondrial biogenesis and energy metabolism. Here we show that the single…”
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Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth by Kemppainen, Esko, George, Jack, Garipler, Görkem, Tuomela, Tea, Kiviranta, Essi, Soga, Tomoyoshi, Dunn, Cory D, Jacobs, Howard T

“…The Drosophila mutant tko25t exhibits a deficiency of mitochondrial protein synthesis, leading to a global insufficiency of respiration and oxidative…”
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Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production by Chua, Yee Liu, Dufour, Eric, Dassa, Emmanuel P., Rustin, Pierre, Jacobs, Howard T., Taylor, Cormac T., Hagen, Thilo

“…The transcription factor hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the cellular response to low oxygen. HIF-1α protein accumulates in…”
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Unique features of DNA replication in mitochondria: A functional and evolutionary perspective by Holt, Ian J., Jacobs, Howard T.

“…Last year, we reported a new mechanism of DNA replication in mammals. It occurs inside mitochondria and entails the use of processed transcripts, termed…”
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Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication by Holmes, J. Bradley, Gokhan Akman, Stuart R. Wood, Kiran Sakhuja, Susana M. Cerritelli, Chloe Moss, Mark R. Bowmaker, Howard T. Jacobs, Robert J. Crouch, Ian J. Holt

“…Encoding ribonuclease H1 (RNase H1) degrades RNA hybridized to DNA, and its function is essential for mitochondrial DNA maintenance in the developing mouse…”
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Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells by Toompuu, Marina, Tuomela, Tea, Laine, Pia, Paulin, Lars, Dufour, Eric, Jacobs, Howard T

“…Abstract RNA 3′ polyadenylation is known to serve diverse purposes in biology, in particular, regulating mRNA stability and translation. Here we determined…”
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Alternative Oxidase Attenuates Cigarette Smoke-induced Lung Dysfunction and Tissue Damage by Giordano, Luca, Farnham, Antoine, Dhandapani, Praveen K, Salminen, Laura, Bhaskaran, Jahnavi, Voswinckel, Robert, Rauschkolb, Peter, Scheibe, Susan, Sommer, Natascha, Beisswenger, Christoph, Weissmann, Norbert, Braun, Thomas, Jacobs, Howard T, Bals, Robert, Herr, Christian, Szibor, Marten

“…Cigarette smoke (CS) exposure is the predominant risk factor for the development of chronic obstructive pulmonary disease (COPD) and the third leading cause of…”
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