Search Results - "Jacobs, Haydee M."

Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo by Rastogi, Archit, Severance, Emily G., Jacobs, Haydee M., Conlin, Sarah M., Islam, Sadia T., Timme-Laragy, Alicia R.

“…Emerging evidence suggests that redox-active chemicals perturb pancreatic islet development. To better understand potential mechanisms for this, we used…”
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Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model by Sant, Karilyn E, Jacobs, Haydee M, Xu, Jiali, Borofski, Katrina A, Moss, Larry G, Moss, Jennifer B, Timme-Laragy, Alicia R

“…The pancreatic islets, largely comprised of insulin-producing beta cells, play a critical role in endocrine signaling and glucose homeostasis. Because they…”
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Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio by Sant, Karilyn E., Sinno, Paul P., Jacobs, Haydee M., Timme-Laragy, Alicia R.

“…•Nrf2a protects against accelerated yolk usage but not pericardial edema or apoptosis induced by PFOS.•PFOS oxidizes the glutathione redox potential in…”
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Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio by Sant, Karilyn E., Jacobs, Haydee M., Borofski, Katrina A., Moss, Jennifer B., Timme-Laragy, Alicia R.

“…Perfluorooctanesulfonic acid (PFOS) is a ubiquitous environmental contaminant, previously utilized as a non-stick application for consumer products and…”
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Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio) by Jacobs, Haydee M., Sant, Karilyn E., Basnet, Aviraj, Williams, Larissa M., Moss, Jennifer B., Timme-Laragy, Alicia R.

“…Mono(2-ethylhexyl) phthalate (MEHP) is the bioactive metabolite of di(2-ethylhexyl) phthalate, a plasticizing agent and persistent environmental contaminant…”
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Pancreas Development and Nutrient Uptake and Utilization Are Disrupted by Embryonic Exposures to the Environmental Toxicant Perfluorooctanesulfonic Acid in the Zebrafish by Sant, Karilyn E, Jacobs, Haydee M, Borofski, Katrina A, Chen, Phoebe, Park, Yeonhwa, Timme‐Laragy, Alicia R

“…Abstract only Several persistent and ubiquitous environmental toxicants have been categorized as diabetogens or obesogens due to their numerous associations…”
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