Search Results - "Jacobs, Graeme Brendon"

Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease by Kozísek, Milan, Henke, Sandra, Sasková, Klára Grantz, Jacobs, Graeme Brendon, Schuch, Anita, Buchholz, Bernd, Müller, Viktor, Kräusslich, Hans-Georg, Rezácová, Pavlína, Konvalinka, Jan, Bodem, Jochen

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding by Chitongo, Rumbidzai, Obasa, Adetayo Emmanuel, Mikasi, Sello Given, Jacobs, Graeme Brendon, Cloete, Ruben

“…Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1…”
Get full text

Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations by Mikasi, Sello Given, Isaacs, Darren, Chitongo, Rumbidzai, Ikomey, George Mondide, Jacobs, Graeme Brendon, Cloete, Ruben

“…The Integrase (IN) strand transfer inhibitor (INSTI), Dolutegravir (DTG), has been given the green light to form part of first-line combination antiretroviral…”
Get full text

Correction: Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding by Chitongo, Rumbidzai, Obasa, Adetayo Emmanuel, Mikasi, Sello Given, Jacobs, Graeme Brendon, Cloete, Ruben

“…[This corrects the article DOI: 10.1371/journal.pone.0223464.]…”
Get full text

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa by Obasa, Adetayo Emmanuel, Mikasi, Sello Given, Brado, Dominik, Cloete, Ruben, Singh, Kamlendra, Neogi, Ujjwal, Jacobs, Graeme Brendon

“…The South African national combination antiretroviral therapy (cART) roll-out program started in 2006, with over 4.4 million people accessing treatment since…”
Get full text

The disproportionate effect of COVID-19 mortality on ethnic minorities: Genetics or health inequalities? by El-Khatib, Ziad, Jacobs, Graeme Brendon, Ikomey, George Mondinde, Neogi, Ujjwal

Get full text

Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa by Obasa, Adetayo Emmanuel, Ambikan, Anoop T, Gupta, Soham, Neogi, Ujjwal, Jacobs, Graeme Brendon

“…HIV-1C has been shown to have a greater risk of virological failure and reduced susceptibility towards boosted protease inhibitors (bPIs), a component of…”
Get full text

Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors by Isaacs, Darren, Mikasi, Sello Given, Obasa, Adetayo Emmanuel, Ikomey, George Mondinde, Shityakov, Sergey, Cloete, Ruben, Jacobs, Graeme Brendon

“…The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN…”
Get full text

Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaoundé, Cameroon: a longitudinal cohort study by Chendi, Bih Hycenta, Okomo Assoumou, Marie Claire, Jacobs, Graeme Brendon, Yekwa, Elsie Laban, Lyonga, Emilia, Mesembe, Martha, Eyoh, Agnes, Ikomey, George Mondinde

“…HIV-load decrease and suppression over time is associated with consistent adherence to antiretroviral therapy (ART). Our study aimed to evaluate the difference…”
Get full text

Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD by Guiedem, Elise, Ikomey, George Mondinde, Nkenfou, Céline, Walter, Pefura-Yone Eric, Mesembe, Martha, Chegou, Novel Njweipi, Jacobs, Graeme Brendon, Okomo Assoumou, Marie Claire

“…The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that of the post tuberculosis…”
Get full text

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease by Guiedem, Elise, Pefura-Yone, Eric Walter, Ikomey, George Mondinde, Nkenfou, Céline Nguefeu, Mesembe, Martha, Yivala, Mbanyamsig Mispa, Chendi, Bih Hycenta, Jacobs, Graeme Brendon, Chegou, Novel Njweipi, Okomo, Marie Claire Assoumou

“…Abstract Background Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease…”
Get full text

HIV-1 subtypes B and C unique recombinant forms (URFs) and transmitted drug resistance identified in the Western Cape Province, South Africa by Jacobs, Graeme Brendon, Wilkinson, Eduan, Isaacs, Shahieda, Spies, Georgina, de Oliveira, Tulio, Seedat, Soraya, Engelbrecht, Susan

“…South Africa has the largest worldwide HIV/AIDS population with 5.6 million people infected and at least 2 million people on antiretroviral therapy. The…”
Get full text

HIV-1 Subtype C Vpr Amino Acid Residue 45Y and Specific Conserved Fragments Are Associated with Neurocognitive Impairment and Markers of Viral Load by Ruhanya, Vurayai, Jacobs, Graeme Brendon, Paul, Robert H, Joska, John A, Seedat, Soraya, Nyandoro, George, Glashoff, Richard Helmuth, Engelbrecht, Susan

“…There is increasing evidence that HIV-1 viral protein R (Vpr) plays an important role in the pathogenesis of cognitive impairment. We investigated the…”
Get more information

Near full-length HIV-1 subtype B sequences from the early South African epidemic, detecting a BD unique recombinant form (URF) from a sample in 1985 by Obasa, Adetayo Emmanuel, Engelbrecht, Susan, Jacobs, Graeme Brendon

“…HIV-1 subtype C is the most prevalent subtype in South Africa. Although subtype B was previously detected in South Africa, there is limited sequence…”
Get full text

Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania by Henerico, Shimba, Mikasi, Sello Given, Kalluvya, Samuel Elias, Brauner, Jan M., Abdul, Seif, Lyimo, Eric, Desderius, Bernard, Korn, Klaus, van Zyl, Gert, Jacobs, Graeme Brendon, Preiser, Wolfgang, Kasang, Christa

“…Abstract Background More than 15 million people in sub-Saharan Africa receive ART. Treatment failure is common, but the role of HIV drug resistance in…”
Get full text

Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa by Brado, Dominik, Obasa, Adetayo Emmanuel, Ikomey, George Mondinde, Cloete, Ruben, Singh, Kamalendra, Engelbrecht, Susan, Neogi, Ujjwal, Jacobs, Graeme Brendon

“…HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context…”
Get full text

Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV by Ruhanya, Vurayai, Jacobs, Graeme Brendon, Nyandoro, George, Paul, Robert H., Joska, John A., Seedat, Soraya, Glashoff, Richard Helmuth, Engelbrecht, Susan

“…It is not known if proviral DNA in the periphery corresponds to cognitive status in clade C as it does in clade B and recombinant forms. A cross-sectional…”
Get full text

HIV-1 subtype C Tat exon-1 amino acid residue 24K is a signature for neurocognitive impairment by Ruhanya, Vurayai, Jacobs, Graeme Brendon, Paul, Robert H., Joska, John A., Seedat, Soraya, Nyandoro, George, Glashoff, Richard H., Engelbrecht, Susan

“…Variation and differential selection pressures on Tat genes have been shown to alter the biological function of the protein, resulting in pathological…”
Get full text

Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa by Brado, Dominik, Obasa, Adetayo Emmanuel, Ikomey, George Mondinde, Cloete, Ruben, Singh, Kamalendra, Engelbrecht, Susan, Neogi, Ujjwal, Jacobs, Graeme Brendon

“…HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context…”
Get full text

HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon by Mikasi, Sello Given, Gichana, Josiah Otwoma, Van der Walt, Cheri, Brado, Dominik, Obasa, Adetayo Emmanuel, Njenda, Duncan, Messembe, Martha, Lyonga, Emilia, Assoumou, Okomo, Cloete, Ruben, Ikomey, George Mondinde, Jacobs, Graeme Brendon

“…The World Health Organization (WHO) has put forth recommendations for the use of integrase (IN) strand transfer inhibitors (INSTIs) to be part of the…”
Get more information