Search Results - "Jacobs, Frank"

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons by Jacobs, Frank M. J., Greenberg, David, Nguyen, Ngan, Haeussler, Maximilian, Ewing, Adam D., Katzman, Sol, Paten, Benedict, Salama, Sofie R., Haussler, David

“…The authors show that two primate-specific genes encoding KRAB domain containing zinc finger proteins, ZNF91 and ZNF93, have evolved during the last 25 million…”
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Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis by Fiddes, Ian T., Lodewijk, Gerrald A., Mooring, Meghan, Bosworth, Colleen M., Ewing, Adam D., Mantalas, Gary L., Novak, Adam M., van den Bout, Anouk, Bishara, Alex, Rosenkrantz, Jimi L., Lorig-Roach, Ryan, Field, Andrew R., Haeussler, Maximilian, Russo, Lotte, Bhaduri, Aparna, Nowakowski, Tomasz J., Pollen, Alex A., Dougherty, Max L., Nuttle, Xander, Addor, Marie-Claude, Zwolinski, Simon, Katzman, Sol, Kriegstein, Arnold, Eichler, Evan E., Salama, Sofie R., Jacobs, Frank M.J., Haussler, David

“…Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and…”
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ZNF91 deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clusters by Haring, Nina L, van Bree, Elisabeth J, Jordaan, Whitney S, Roels, Judith R E, Sotomayor, Gonzalo Congrains, Hey, Tiziana M, White, Fred T G, Galland, Marc D, Smidt, Marten P, Jacobs, Frank M J

“…Transposable element (TE) invasions have shaped vertebrate genomes over the course of evolution. They have contributed an extra layer of species-specific gene…”
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A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci by van Bree, Elisabeth J, Guimarães, Rita L F P, Lundberg, Mischa, Blujdea, Elena R, Rosenkrantz, Jimi L, White, Fred T G, Poppinga, Josse, Ferrer-Raventós, Paula, Schneider, Anne-Fleur E, Clayton, Isabella, Haussler, David, Reinders, Marcel J T, Holstege, Henne, Ewing, Adam D, Moses, Colette, Jacobs, Frank M J

“…Genome-wide association studies (GWAS) have been highly informative in discovering disease-associated loci but are not designed to capture all structural…”
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Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells by Ayala-Nunez, Nilda Vanesa, Follain, Gautier, Delalande, François, Hirschler, Aurélie, Partiot, Emma, Hale, Gillian L., Bollweg, Brigid C., Roels, Judith, Chazal, Maxime, Bakoa, Florian, Carocci, Margot, Bourdoulous, Sandrine, Faklaris, Orestis, Zaki, Sherif R., Eckly, Anita, Uring-Lambert, Béatrice, Doussau, Frédéric, Cianferani, Sarah, Carapito, Christine, Jacobs, Frank M. J., Jouvenet, Nolwenn, Goetz, Jacky G., Gaudin, Raphael

“…Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe neurological diseases. However the virus journey, from the…”
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Long Non-Coding RNAs in Neuronal Aging by Pereira Fernandes, Diana, Bitar, Mainá, Jacobs, Frank M J, Barry, Guy

“…The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been associated with the emergence of sophisticated regulatory networks that may have…”
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Widespread correlation of KRAB zinc finger protein binding with brain-developmental gene expression patterns by Farmiloe, Grace, Lodewijk, Gerrald A, Robben, Stijn F, van Bree, Elisabeth J, Jacobs, Frank M J

“…The large family of KRAB zinc finger (KZNF) genes are transcription factors implicated in recognizing and repressing repetitive sequences such as transposable…”
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The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles by Coulter, Michael E., Dorobantu, Cristina M., Lodewijk, Gerrald A., Delalande, François, Cianferani, Sarah, Ganesh, Vijay S., Smith, Richard S., Lim, Elaine T., Xu, C. Shan, Pang, Song, Wong, Eric T., Lidov, Hart G.W., Calicchio, Monica L., Yang, Edward, Gonzalez, Dilenny M., Schlaeger, Thorsten M., Mochida, Ganeshwaran H., Hess, Harald, Lee, Wei-Chung Allen, Lehtinen, Maria K., Kirchhausen, Tomas, Haussler, David, Jacobs, Frank M.J., Gaudin, Raphael, Walsh, Christopher A.

“…Endosomal sorting complex required for transport (ESCRT) complex proteins regulate biogenesis and release of extracellular vesicles (EVs), which enable…”
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Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels by Lodewijk, Gerrald A, Fernandes, Diana P, Vretzakis, Iraklis, Savage, Jeanne E, Jacobs, Frank M J

“…Abstract Ever since the availability of genomes from Neanderthals, Denisovans, and ancient humans, the field of evolutionary genomics has been searching for…”
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The Role of Liver Sinusoidal Cells in Hepatocyte-Directed Gene Transfer by Jacobs, Frank, Wisse, Eddie, De Geest, Bart

“…Hepatocytes are a key target for gene therapy of inborn errors of metabolism as well as of acquired diseases such as liver cancer and hepatitis. Gene transfer…”
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Concrete quality on-site vs separately manufactured specimens by Jacobs, Frank

“…In most cases insufficient durability is the reason for concrete damages and not insufficient strength. Therefore, the Swiss concrete standard SN EN 206 set up…”
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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease by Bell, Catherine C., Hendriks, Delilah F. G., Moro, Sabrina M. L., Ellis, Ewa, Walsh, Joanne, Renblom, Anna, Fredriksson Puigvert, Lisa, Dankers, Anita C. A., Jacobs, Frank, Snoeys, Jan, Sison-Young, Rowena L., Jenkins, Rosalind E., Nordling, Åsa, Mkrtchian, Souren, Park, B. Kevin, Kitteringham, Neil R., Goldring, Christopher E. P., Lauschke, Volker M., Ingelman-Sundberg, Magnus

“…Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human…”
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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study by Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, Houdt, Jos van, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus

“…Abstract Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced liver injury. However, when cultured as 2D monolayers, PHH…”
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ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia-parkinsonism (XDP) by Rosenkrantz, Jimi L, Brandorff, J Elias, Raghib, Sanaz, Kapadia, Ashni, Vaine, Christine A, Bragg, D Cristopher, Farmiloe, Grace, Jacobs, Frank M J

“…X-linked dystonia-parkinsonism (XDP) is a severe neurodegenerative disorder resulting from an inherited intronic SINE-Alu-VNTR (SVA) retrotransposon in the…”
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Emergence of the ZNF675 Gene During Primate Evolution–Influenced Human Neurodevelopment Through Changing HES1 Autoregulation by Lodewijk, Gerrald A., Geus, Matthijs, Guimarães, Rita L. F. P., Jacobs, Frank M. J.

“…ABSTRACT In this study, we investigated recurrent copy number variations (CNVs) in the 19p12 locus, which are associated with neurodevelopmental disorders. The…”
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Structurally Conserved Primate LncRNAs Are Transiently Expressed during Human Cortical Differentiation and Influence Cell-Type-Specific Genes by Field, Andrew R., Jacobs, Frank M.J., Fiddes, Ian T., Phillips, Alex P.R., Reyes-Ortiz, Andrea M., LaMontagne, Erin, Whitehead, Lila, Meng, Vincent, Rosenkrantz, Jimi L., Olsen, Mari, Hauessler, Max, Katzman, Sol, Salama, Sofie R., Haussler, David

“…The cerebral cortex has expanded in size and complexity in primates, yet the molecular innovations that enabled primate-specific brain attributes remain…”
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Structural Evolution of Gene Promoters Driven by Primate-Specific KRAB Zinc Finger Proteins by Farmiloe, Grace, van Bree, Elisabeth J, Robben, Stijn F, Janssen, Lara J M, Mol, Lisa, Jacobs, Frank M J

“…Krüppel-associated box (KRAB) zinc finger proteins (KZNFs) recognize and repress transposable elements (TEs); TEs are DNA elements that are capable of…”
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Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines by Boon, Ruben, Kumar, Manoj, Tricot, Tine, Elia, Ilaria, Ordovas, Laura, Jacobs, Frank, One, Jennifer, De Smedt, Jonathan, Eelen, Guy, Bird, Matthew, Roelandt, Philip, Doglioni, Ginevra, Vriens, Kim, Rossi, Matteo, Vazquez, Marta Aguirre, Vanwelden, Thomas, Chesnais, François, El Taghdouini, Adil, Najimi, Mustapha, Sokal, Etienne, Cassiman, David, Snoeys, Jan, Monshouwer, Mario, Hu, Wei-Shou, Lange, Christian, Carmeliet, Peter, Fendt, Sarah-Maria, Verfaillie, Catherine M.

“…Predicting drug-induced liver injury in a preclinical setting remains challenging, as cultured primary human hepatocytes (PHHs), pluripotent stem cell-derived…”
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“Can You Deny Her That?” Processes of Governmentality and Socialization of Parents in Elite Women’s Gymnastics by Smits, Froukje, Jacobs, Frank, Knoppers, Annelies

“…Abusive practices in elite women’s artistic gymnastics (WAG) have been the focus of discussions about how to eliminate or reduce them. Both coaches and parents…”
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Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression by Jacobs, Frank M J, van Erp, Susan, van der Linden, Annemarie J A, von Oerthel, Lars, Burbach, J Peter H, Smidt, Marten P

“…In recent years, the meso-diencephalic dopaminergic (mdDA) neurons have been extensively studied for their association with Parkinson's disease. Thus far,…”
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