Search Results - "Jacobs, Aaron T."

HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins by Jacobs, Aaron T., Marnett, Lawrence J.

“…4-Hydroxynonenal (HNE) is a pro-apoptotic electrophile generated during the spontaneous decomposition of oxidized lipids. We have previously shown that HNE…”
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Breast Adipocyte Co-culture Increases the Expression of Pro-angiogenic Factors in Macrophages by Yadav, Nalini V S, Barcikowski, Arthur, Uehana, Yuko, Jacobs, Aaron T, Connelly, Linda

“…Obese individuals with breast cancer have a poorer prognosis and higher risk of metastatic disease vs. non-obese patients. Adipose tissue in obese individuals…”
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Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl Derivatives by Vila, Andrew, Tallman, Keri A, Jacobs, Aaron T, Liebler, Daniel C, Porter, Ned A, Marnett, Lawrence J

“…Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic α,β-unsaturated aldehydes, such…”
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Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes by Pinner, Keanu D., Wales, Christina T. K., Gristock, Rachel A., Vo, Hoa T., So, Nadine, Jacobs, Aaron T.

“…Context Flavokawains are secondary metabolites from the kava plant (Piper methysticum Forst. f., Piperaceae) that have anticancer properties and demonstrated…”
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Macrophage Endothelial Nitric-oxide Synthase Autoregulates Cellular Activation and Pro-inflammatory Protein Expression by Connelly, Linda, Jacobs, Aaron T., Palacios-Callender, Miriam, Moncada, Salvador, Hobbs, Adrian J.

“…Expression of inducible nitric-oxide (NO) synthase (iNOS) and “high-output” production of NO by macrophages mediates many cytotoxic actions of these immune…”
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Targeted therapy for breast cancer: An overview of drug classes and outcomes by Jacobs, Aaron T., Martinez Castaneda-Cruz, Diana, Rose, Mark M., Connelly, Linda

“…[Display omitted] The last 25 years have seen significant growth in new therapeutic options for breast cancer, termed targeted therapies based on their ability…”
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RELT stains prominently in B-cell lymphomas and binds the hematopoietic transcription factor MDFIC by Cusick, John K., Alhomsy, Yasmeen, Wong, Stephanie, Talbott, George, Uversky, Vladimir N., Hart, Cara, Hejazi, Nazila, Jacobs, Aaron T., Shi, Yihui

“…Receptor Expressed in Lymphoid Tissues (RELT) is a human tumor necrosis factor receptor superfamily member (TNFRSF) that is expressed most prominently in cells…”
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Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress by Jacobs, Aaron T, Marnett, Lawrence J

“…Biological electrophiles result from oxidative metabolism of exogenous compounds or endogenous cellular constituents, and they contribute to pathophysiologies…”
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Altersolanol B, a fungal tetrahydroanthraquinone, inhibits the proliferation of estrogen receptor-expressing (ER+) human breast adenocarcinoma by modulating PI3K/AKT, p38/ERK MAPK and associated signaling pathways by Siraj, Md Afjalus, Jacobs, Aaron T., Tan, Ghee T.

“…The present study focused on the apoptosis-inducing effects and cellular signal-modulating properties of altersolanol B (AB), a minor fungal…”
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IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells by Wei, L H, Jacobs, A T, Morris, Jr, S M, Ignarro, L J

“…The objectives of this study were to determine whether rat aortic smooth muscle cells (RASMC) express arginase and to elucidate the possible mechanisms…”
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Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux by Samarasinghe, Buddhini, Wales, Christina T.K., Taylor, Frederick R., Jacobs, Aaron T.

“…Heat shock protein 90 (Hsp90) has an important role in many cancers. Biochemical inhibitors of Hsp90 are in advanced clinical development for the treatment of…”
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Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL by Jacobs, Aaron T, Marnett, Lawrence J

“…Lipid peroxidation is a consequence of both normal physiology and oxidative stress that generates various reactive metabolites, a principal end product being…”
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RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-α secretion by Rouzer, Carol A., Jacobs, Aaron T., Nirodi, Chetan S., Kingsley, Philip J., Morrow, Jason D., Marnett, Lawrence J.

“…Studies of the response of RAW264.7 cells (RAW) to lipopolysaccharide (LPS) were carried out to determine why these cells do not demonstrate the prostaglandin…”
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Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies by DeGuire, Sean M., Earl, David C., Du, Yu, Crews, Brenda A., Jacobs, Aaron T., Ustione, Alessandro, Daniel, Cristina, Chong, Katherine M., Marnett, Lawrence J., Piston, David W., Bachmann, Brian O., Sulikowski, Gary A.

“…Apoptolidin A has been described among the top 0.1 % most‐cell‐selective cytotoxic agents to be evaluated in the NCI 60 cell line panel. The molecular…”
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ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells by Wales, Christina T.K, Taylor, Frederick R, Higa, Allan T, McAllister, Harvey A, Jacobs, Aaron T

“…Drugs containing the benzimidazole carbamate scaffold include anthelmintic and antifungal agents, and they are now also recognized as having potential…”
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Identification of PLSCR1 as a protein that interacts with RELT family members by Cusick, John K., Mustian, Andrea, Jacobs, Aaron T., Reyland, Mary E.

“…Receptor expressed in lymphoid tissues (RELT) proteins are recently described surface receptors belonging to the larger TNF receptor family. To improve our…”
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Conservative Secondary Shell Substitution In Cyclooxygenase‑2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics by Konkle, Mary E, Blobaum, Anna L, Moth, Christopher W, Prusakiewicz, Jeffery J, Xu, Shu, Ghebreselasie, Kebreab, Akingbade, Dapo, Jacobs, Aaron T, Rouzer, Carol A, Lybrand, Terry P, Marnett, Lawrence J

“…The cyclooxygenase enzymes (COX-1 and COX-2) are the therapeutic targets of nonsteroidal anti-inflammatory drugs (NSAIDs). Neutralization of the carboxylic…”
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Combined Chemical and Biosynthetic Route to Access a New Apoptolidin Congener by Ghidu, Victor P, Ntai, Ioanna, Wang, Jingqi, Jacobs, Aaron T, Marnett, Lawrence J, Bachmann, Brian O, Sulikowski, Gary A

“…Glycosylation of a synthetic aglycone using precursor-directed biosynthesis is facilitated by a chemical ketosynthase “knockdown” of the apoptolidin producer…”
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ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells by Wales, Christina T.K., Taylor, Frederick R., Higa, Allan T., McAllister, Harvey A., Jacobs, Aaron T.

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Heat Shock Factor 1 Attenuates 4-Hydroxynonenal-mediated Apoptosis by Jacobs, Aaron T., Marnett, Lawrence J.

“…Lipid peroxidation is a consequence of both normal physiology and oxidative stress that generates various reactive metabolites, a principal end product being…”
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