Search Results - "Jacobien A. Noordhoek"

miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD by Osei, Emmanuel T, Florez-Sampedro, Laura, Tasena, Hataitip, Faiz, Alen, Noordhoek, Jacobien A, Timens, Wim, Postma, Dirkje S, Hackett, Tillie L, Heijink, Irene H, Brandsma, Corry-Anke

“…We previously reported that epithelial-derived interleukin (IL)-1α drives fibroblast-derived inflammation in the lung epithelial-mesenchymal trophic unit…”
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House Dust Mite-Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium by Heijink, Irene H, Postma, Dirkje S, Noordhoek, Jacobien A, Broekema, Martine, Kapus, Andras

“…The molecular basis of airway remodeling and loss of epithelial integrity in asthma is still undefined. We aimed to establish if exposure of human bronchial…”
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Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease by Heijink, Irene H, Noordhoek, Jacobien A, Timens, Wim, van Oosterhout, Antoon J M, Postma, Dirkje S

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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation by Ng-Blichfeldt, John-Poul, Schrik, Anneke, Kortekaas, Rosa K., Noordhoek, Jacobien A., Heijink, Irene H., Hiemstra, Pieter S., Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud

“…Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease…”
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A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract by Chen, Qing, de Vries, Maaike, Nwozor, Kingsley Okechukwu, Noordhoek, Jacobien A, Brandsma, Corry-Anke, Boezen, H Marike, Heijink, Irene H

“…Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by chronic inflammation upon inhalation of noxious particles, e.g.,…”
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Dysregulated cross-talk between alveolar epithelial cells and stromal cells in idiopathic pulmonary fibrosis reduces epithelial regenerative capacity by Wisman, Marissa, Nizamoglu, Mehmet, Noordhoek, Jacobien A., Timens, Wim, Burgess, Janette K., Heijink, Irene H.

“…In idiopathic pulmonary fibrosis (IPF) constant epithelial micro-injury and aberrant interactions within the stromal micro-environment lead to abnormal…”
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Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma by Faura Tellez, Grissel, Willemse, Brigitte W M, Brouwer, Uilke, Nijboer-Brinksma, Susan, Vandepoele, Karl, Noordhoek, Jacobien A, Heijink, Irene, de Vries, Maaike, Smithers, Natalie P, Postma, Dirkje S, Timens, Wim, Wiffen, Laura, van Roy, Frans, Holloway, John W, Lackie, Peter M, Nawijn, Martijn C, Koppelman, Gerard H

“…The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion molecule of unknown function expressed in the airway epithelium. Here, we characterize the…”
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Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells by Kruk, Dennis M L W, Wisman, Marissa, Noordhoek, Jacobien A, Nizamoglu, Mehmet, Jonker, Marnix R, de Bruin, Harold G, Arevalo Gomez, Karla, Ten Hacken, Nick H T, Pouwels, Simon D, Heijink, Irene H

“…COPD is characterized by irreversible lung tissue damage. We hypothesized that lung-derived mesenchymal stromal cells (LMSCs) reduce alveolar epithelial damage…”
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Expression of ADAMs (“a disintegrin and metalloprotease”) in the human lung by Dijkstra, Antoon, Postma, Dirkje S., Noordhoek, Jacobien A., Lodewijk, Monique E., Kauffman, Henk F., ten Hacken, Nick H. T., Timens, Wim

“…In view of the associations of “a disintegrin and metalloprotease” (ADAM) with respiratory diseases, we assessed the expression of various ADAMs in human lung…”
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Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD by Zandvoort, Andre, Postma, Dirkje S, Jonker, Marnix R, Noordhoek, Jacobien A, Vos, Johannes T W M, Timens, Wim

“…Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking…”
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Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD by Heijink, Irene H, Brandenburg, Simone M, Noordhoek, Jacobien A, Slebos, Dirk-Jan, Postma, Dirkje S, van Oosterhout, Antoon J

“…Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether…”
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SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells by Di Vincenzo, Serena, Heijink, Irene H., Noordhoek, Jacobien A., Cipollina, Chiara, Siena, Liboria, Bruno, Andreina, Ferraro, Maria, Postma, Dirkje S., Gjomarkaj, Mark, Pace, Elisabetta

“…Inflammation and ageing are intertwined in chronic obstructive pulmonary disease (COPD). The histone deacetylase SIRT1 and the related activation of FoxO3…”
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Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD by Osei, Emmanuel T, Noordhoek, Jacobien A, Hackett, Tillie L, Spanjer, Anita I R, Postma, Dirkje S, Timens, Wim, Brandsma, Corry-Anke, Heijink, Irene H

“…Chronic obstructive pulmonary disease (COPD) has been associated with aberrant epithelial-mesenchymal interactions resulting in inflammatory and remodelling…”
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Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD by Heijink, Irene H, de Bruin, Harold G, Dennebos, Robin, Jonker, Marnix R, Noordhoek, Jacobien A, Brandsma, Corry-Anke, van den Berge, Maarten, Postma, Dirkje S

“…Wingless/integrase-1 (WNT) signalling is associated with lung inflammation and repair, but its role in chronic obstructive pulmonary disease (COPD)…”
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Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD by Brandsma, Corry-Anke, Timens, Wim, Jonker, Marnix R, Rutgers, Bea, Noordhoek, Jacobien A, Postma, Dirkje S

“…Chronic obstructive pulmonary disease (COPD) is characterized by abnormal repair in the lung resulting in airway obstruction associated with emphysema and…”
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Inhibition of β‐catenin/CBP signalling improves airway epithelial barrier function and suppresses CCL20 release by Kuchibhotla, Virinchi N. S., Jonker, Marnix R., Bruin, Harold G., Noordhoek, Jacobien A., Knight, Darryl A., Nawijn, Martijn C., Heijink, Irene H.

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SIRT 1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells by Di Vincenzo, Serena, Heijink, Irene H., Noordhoek, Jacobien A., Cipollina, Chiara, Siena, Liboria, Bruno, Andreina, Ferraro, Maria, Postma, Dirkje S., Gjomarkaj, Mark, Pace, Elisabetta

“…Inflammation and ageing are intertwined in chronic obstructive pulmonary disease ( COPD ). The histone deacetylase SIRT 1 and the related activation of FoxO3…”
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Effects of budesonide and formoterol on eosinophil activation induced by human lung fibroblasts by SPOELSTRA, Fokje M, KAUFFMAN, Henk F, HOVENGA, Hessel, NOORDHOEK, Jacobien A, DE MONCHY, Jan G. R, POSTMA, Dirkje S

“…Budesonide and formoterol are extensively used in current asthma therapy. Budesonide is known as potent antiinflammatory agent and formoterol also appears to…”
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Interaction of airway epithelial cells (A549) with spores and mycelium of Aspergillus fumigatus by Zhang, Zhihong, Liu, Rongyu, Noordhoek, Jacobien A., Kauffman, Henk F.

“…To study the interaction of airway epithelial cell line A549 with fragments of mycelium, spores of Aspergillus fumigatus in vitro and to determine if toll-like…”
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Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema by Noordhoek, Jacobien A, Postma, Dirkje S, Chong, Luis L, Menkema, Lorian, Kauffman, Henk F, Timens, Wim, van Straaten, Jeanette F M, van der Geld, Ymke M

“…We have previously reported diminished immunohistochemical staining of decorin in lung tissue from patients with severe emphysema. The aim of this study is to…”
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