Search Results - "Jacobi, Paula"

Whole-exome sequencing identifies rare variants in STAB2 associated with venous thromboembolic disease by Desch, Karl C., Ozel, Ayse B., Halvorsen, Matt, Jacobi, Paula M., Golden, Krista, Underwood, Mary, Germain, Marine, Tregouet, David-Alexandre, Reitsma, Pieter H., Kearon, Clive, Mokry, Lauren, Richards, J. Brent, Williams, Frances, Li, Jun Z., Goldstein, David, Ginsburg, David

“…Deep vein thrombosis and pulmonary embolism, collectively defined as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in the…”
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Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A by Du, Lily M., Nurden, Paquita, Nurden, Alan T., Nichols, Timothy C., Bellinger, Dwight A., Jensen, Eric S., Haberichter, Sandra L., Merricks, Elizabeth, Raymer, Robin A., Fang, Juan, Koukouritaki, Sevasti B., Jacobi, Paula M., Hawkins, Troy B., Cornetta, Kenneth, Shi, Qizhen, Wilcox, David A.

“…It is essential to improve therapies for controlling excessive bleeding in patients with haemorrhagic disorders. As activated blood platelets mediate the…”
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Crucial role for the VWF A1 domain in binding to type IV collagen by Flood, Veronica H., Schlauderaff, Abraham C., Haberichter, Sandra L., Slobodianuk, Tricia L., Jacobi, Paula M., Bellissimo, Daniel B., Christopherson, Pamela A., Friedman, Kenneth D., Gill, Joan Cox, Hoffmann, Raymond G., Montgomery, Robert R.

“…Von Willebrand factor (VWF) contains binding sites for platelets and for vascular collagens to facilitate clot formation at sites of injury. Although previous…”
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Collagen binding provides a sensitive screen for variant von Willebrand disease by Flood, Veronica H, Gill, Joan Cox, Friedman, Kenneth D, Christopherson, Pamela A, Jacobi, Paula M, Hoffmann, Raymond G, Montgomery, Robert R, Haberichter, Sandra L

“…von Willebrand factor (VWF) is a multimeric protein that binds platelets and collagen, facilitating hemostasis at sites of vessel injury. Measurement of VWF…”
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Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage by Jacobi, Paula M., Gill, Joan Cox, Flood, Veronica H., Jakab, David A., Friedman, Kenneth D., Haberichter, Sandra L.

“…Type 2A VWD is characterized by the absence of large VWF multimers and decreased platelet-binding function. Historically, type 2A variants are subdivided into…”
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Neuropeptide FF receptors have opposing modulatory effects on nociception by Lameh, Jelveh, Bertozzi, Fabio, Kelly, Nicholas, Jacobi, Paula M, Nguyen, Derek, Bajpai, Abhishek, Gaubert, Gilles, Olsson, Roger, Gardell, Luis R

“…The role of neuropeptide FF (NPFF) and its analogs in pain modulation is ambiguous. Although NPFF was first characterized as an antiopioid peptide, both…”
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Mutations in the D′D3 region of VWF traditionally associated with type 1 VWD lead to quantitative and qualitative deficiencies of VWF by White-Adams, Tara C, Ng, Christopher J, Jacobi, Paula M, Haberichter, Sandra L, Di Paola, Jorge A

“…Abstract Type 1 von Willebrand disease (VWD) is characterized by low plasma levels of von Willebrand factor (VWF) and clinical bleeding. Several mechanisms…”
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Mutations in the D'D3 region of VWF traditionally associated with type 1 VWD lead to quantitative and qualitative deficiencies of VWF by White-Adams, Tara C, Ng, Christopher J, Jacobi, Paula M, Haberichter, Sandra L, Di Paola, Jorge A

“…Type 1 von Willebrand disease (VWD) is characterized by low plasma levels of von Willebrand factor (VWF) and clinical bleeding. Several mechanisms have been…”
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Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels by Ma, Qianyi, Jacobi, Paula M., Emmer, Brian T., Kretz, Colin A., Ozel, Ayse Bilge, McGee, Beth, Kimchi-Sarfaty, Chava, Ginsburg, David, Li, Jun Z., Desch, Karl C.

“…The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) in circulating blood, limiting the size of VWF multimers and regulating VWF activity. Abnormal…”
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Von Willebrand Factor Activates the Alternative Complement Pathway In Vivo in a Mouse Model of Complement Thrombotic Microangiopathy by Jacobi, Paula M, Sartain, Sarah E

“…Introduction Thrombotic microangiopathy (TMA) is a group of disorders presenting with microvascular thrombosis, microangiopathic hemolytic anemia,…”
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Complement Activation Is Associated with Endothelial Damage in Hematopoietic Stem Cell Transplant Associated-Thrombotic Microangiopathy by Jacobi, Paula M, Cofiell, Roxanne, Chang, C-Hong, Kim, SungKwon, Sartain, Sarah E

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Von Willebrand Factor Propeptide to Antigen Ratio Identifies Platelet Activation and Reduced VWF Survival Phenotype in Mice by Jacobi, Paula M., Kanaji, Sachiko, Jakab, David, Gehrand, Ashley L., Johnsen, Jill M., Haberichter, Sandra L.

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Upstream Mechanisms Causing Type 1C Von Willebrand Disease (VWD): Contribution Of Defective Von Willebrand Factor (VWF) Multimerization, Regulated Storage, and Secretion by Haberichter, Sandra L., Jakab, David A, Jacobi, Paula M.

“…One mechanism causing type 1 VWD is the reduced survival of VWF in plasma (type 1C VWD), characterized by markedly decreased VWF:Ag and VWF half-life,…”
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Development and Validation of a Chromogenic Direct Thrombin Inhibitor Assay on the ACL Top 700 for Quantifying Dabigatran Levels in Plasma by Jacobi, Paula M, Covill, Sharniece, Podd, Andrew S, Friedman, Kenneth D, Haberichter, Sandra L

“…Dabigatran is a potent, competitive, and reversible direct thrombin inhibitor, that binds to the active site of thrombin, inhibiting both free and clot-bound…”
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Exome Sequencing in Venous Thromboembolic Disease Identifies Excess Mutation Burden in PROS1, PROC, SERPINC1 and STAB2 by Desch, Karl C., Ozel, Ayse Bilge, Halvorsen, Matt, Jacobi, Paula M., Germain, Marine, Tregouet, David Alexandre, Reitsma, Pieter H., Goldstein, David, Ginsburg, David

“…Deep vein thrombosis and pulmonary embolism, collectively referred to as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in…”
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Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease by Chen, Junmei, Hinckley, Jesse D., Haberichter, Sandra, Jacobi, Paula, Montgomery, Robert, Flood, Veronica H., Wong, Randall, Interlandi, Gianluca, Chung, Dominic W., López, José A., Di Paola, Jorge

“…Von Willebrand disease (VWD) is an inherited bleeding disorder characterized by incomplete penetrance and variable expressivity. We evaluated a 24-member…”
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A Native Whole Blood Thrombin Generation Assay Allows Discrimination of Whole Blood Samples with FVIII Levels below 1 by Baumgartner, Christina K, Roberts, Jonathan C, Jacobi, Paula M, Haberichter, Sandra L, Shi, Qizhen, Montgomery, Robert R.

“…Monitoring the correction of abnormal bleeding tendencies during the treatment of patients with hemostatic disorders is essential to evaluate success of…”
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A New Microfluidic-Based Platelet Rolling Assay to Better Characterize VWD Phenotypes by White-Adams, Tara C, Jacobi, Paula M, Haberichter, Sandra L, Neeves, Keith B, Di Paola, Jorge A

“…Abstract 3386 Von Willebrand disease (VWD), the most frequently diagnosed bleeding disorder, is characterized by variable expressivity and incomplete…”
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VWF Interaction With Type IV Collagen Is Mediated Through Critical VWF A1 Domain Residues by Flood, Veronica H., Schlauderaff, Abraham C., Jacobi, Paula M., Slobodianuk, Tricia L., Montgomery, Robert R., Haberichter, Sandra L., Program Investigators, The Zimmerman

“…Von Willebrand factor (VWF) plays a key role in coagulation by tethering platelets to injured subendothelium via binding sites for platelet glycoprotein Ib and…”
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Molecular Analysis of Type 1 VWD Mutations: Effects of Mutant:Wild-Type Transfection Ratio and Protein Degradation by White-Adams, Tara C, Jacobi, Paula M, Haberichter, Sandra L, Di Paola, Jorge A

“…Abstract 1210 Von Willebrand disease (VWD), the most frequently diagnosed bleeding disorder, is characterized by variable expressivity and incomplete…”
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