Search Results - "Jacob van den Born"

Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling by Huang, Fengjuan, Zhao, Yanyan, Wang, Qingzhu, Hillebrands, Jan-Luuk, van den Born, Jacob, Ji, Linlin, An, Tingting, Qin, Guijun

“…Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a…”
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Antigen and Cell-Based Assays for the Detection of Non-HLA Antibodies by Lammerts, Rosa G M, Altulea, Dania, Hepkema, Bouke G, Sanders, Jan-Stephan, van den Born, Jacob, Berger, Stefan P

“…To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute and chronic antibody-mediated rejection (AMBR) in solid-organ…”
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Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells by Zhang, Xinmiao, Rodriguez-Niño, Angelica, Pastene, Diego O., Pallavi, Prama, van den Born, Jacob, Bakker, Stephan J. L., Krämer, Bernhard K., Yard, Benito A.

“…Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded as a pivotal mediator of vascular damage in patients with diabetes. We…”
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Pretransplant endotrophin predicts delayed graft function after kidney transplantation by Tepel, Martin, Alkaff, Firas F., Kremer, Daan, Bakker, Stephan J. L., Thaunat, Olivier, Nagarajah, Subagini, Saleh, Qais, Berger, Stefan P., van den Born, Jacob, Krogstrup, Nicoline V., Nielsen, Marie B., Nørregaard, Rikke, Jespersen, Bente, Sparding, Nadja, Genovese, Federica, Karsdal, Morten A., Rasmussen, Daniel G. K.

“…Delayed graft function after kidney transplantation is common and increases morbidity and health care costs. There is evidence that endotrophin, a specific…”
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Renal Endothelial Cytotoxicity Assay to Diagnose and Monitor Renal Transplant Recipients for Anti-Endothelial Antibodies by Lammerts, Rosa G. M., Born, Jacob van den, Huberts-Kregel, Magdalena, Gomes-Neto, Antonio W., Daha, Mohammed R., Hepkema, Bouke G., Sanders, Jan-Stephan, Pol, Robert A., Diepstra, Arjan, Berger, Stefan P.

“…Tissue-specific nonhuman leukocyte antigen (HLA) antigens can play crucial roles in allograft immunity and have been shown to trigger humoral responses leading…”
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Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation by Celie, Johanna W A M, Katta, Kiran K, Adepu, Saritha, Melenhorst, Wynand B W H, Reijmers, Rogier M, Slot, Edith M, Beelen, Robert H J, Spaargaren, Marcel, Ploeg, Rutger J, Navis, Gerjan, van der Heide, Jaap J Homan, van Dijk, Marcory C R F, van Goor, Harry, van den Born, Jacob

“…Syndecan-1, a heparan sulfate proteoglycan, has an important role in wound healing by binding several growth factors and cytokines. As these processes are also…”
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The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration by van den Born, Jaap, Bakker, Stephan J. L., Köppel, Hannes, Schnuelle, Peter, Krämer, Bernhard K., Yard, Benito A., Hauske, Sibylle J., Claus Peter, Schmitt, Peters, Verena, Qiu, Jiedong, Rodriquez, Angelica, Xia, Li, Braun, Jana D., Zhang, Shiqi, Albrecht, Thomas, Lammert, Alexander

“…Considering that the homozygous CNDP1 (CTG)5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study…”
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Glomerular Endothelial Cells as Instigators of Glomerular Sclerotic Diseases by Sol, Marloes, Kamps, Jan A. A. M., van den Born, Jacob, van den Heuvel, Marius C., van der Vlag, Johan, Krenning, Guido, Hillebrands, Jan-Luuk

“…Glomerular endothelial cell (GEnC) dysfunction is important in the pathogenesis of glomerular sclerotic diseases, including Focal Segmental Glomerulosclerosis…”
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Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice by Albrecht, Thomas, Schilperoort, Maaike, Zhang, Shiqi, Braun, Jana D., Qiu, Jiedong, Rodriguez, Angelica, Pastene, Diego O., Krämer, Bernhard K., Köppel, Hannes, Baelde, Hans, de Heer, Emile, Anna Altomare, Alessandra, Regazzoni, Luca, Denisi, Alessandra, Aldini, Giancarlo, van den Born, Jacob, Yard, Benito A., Hauske, Sibylle J.

“…We previously demonstrated that polymorphisms in the carnosinase-1 gene (CNDP1) determine the risk of nephropathy in type 2 diabetic patients. Carnosine, the…”
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Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia by Shrestha, Pragyi, van de Sluis, Bart, Dullaart, Robin P.F., van den Born, Jacob

“…Chronic kidney disease (CKD) is a global health problem with a profound impact on quality of life. Cardiovascular disease is established as a major cause of…”
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Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy by Talsma, Ditmer T., Katta, Kirankumar, Ettema, Marieke A.B., Kel, Berna, Kusche-Gullberg, Marion, Daha, Moh R., Stegeman, Coen A., van den Born, Jacob, Wang, Lianchun

“…Inflammation plays a vital role in the development of diabetic nephropathy, but the underlying regulatory mechanisms are only partially understood. Our…”
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Circulating FGF21 Concentration, Fasting Plasma Glucose, and the Risk of Type 2 Diabetes: Results From the PREVEND Study by Post, Adrian, Dam, Wendy A, Sokooti, Sara, Groothof, Dion, Gloerich, Jolein, van Gool, Alain J, Kremer, Daan, Gansevoort, Ron T, van den Born, Jacob, Kema, Ido P, Franssen, Casper F M, Dullaart, Robin P F, Bakker, Stephan J L

“…Abstract Objective Fibroblast growth factor 21 (FGF21) is a peptide hormone synthesized by several organs and regulates, among others, energy homeostasis. In…”
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Urinary vanin-1, tubular injury, and graft failure in kidney transplant recipients by Alkaff, Firas F., Kremer, Daan, Niekolaas, Tessa M., van den Born, Jacob, Rimbach, Gerald, Tseng, Tzu-Ling, Berger, Stefan P., Bakker, Stephan J. L., de Borst, Martin H.

“…We investigated whether urinary vascular non-inflammatory molecule-1 (vanin-1), a promising early-onset tubular injury marker, correlates with other…”
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Pretransplant characteristics of kidney transplant recipients that predict posttransplant outcome by Tepel, Martin, Nagarajah, Subagini, Saleh, Qais, Thaunat, Olivier, Bakker, Stephan J. L., van den Born, Jacob, Karsdal, Morten A., Genovese, Federica, Rasmussen, Daniel G. K.

“…Better characterization of the potential kidney transplant recipient using novel biomarkers, for example, pretransplant plasma endotrophin, will lead to…”
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Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells by Braun, Jana D., Pastene, Diego O., Breedijk, Annette, Rodriguez, Angelica, Hofmann, Björn B., Sticht, Carsten, von Ochsenstein, Elke, Allgayer, Heike, van den Born, Jacob, Bakker, Stephan, Hauske, Sibylle J., Krämer, Bernhard K., Yard, Benito A., Albrecht, Thomas

“…Although methylglyoxal (MGO) has emerged as key mediator of diabetic microvascular complications, the influence of MGO on the vascular transcriptome has not…”
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High sodium diet converts renal proteoglycans into pro-inflammatory mediators in rats by Hijmans, Ryanne S, Shrestha, Pragyi, Sarpong, Kwaku A, Yazdani, Saleh, El Masri, Rana, de Jong, Wilhelmina H A, Navis, Gerjan, Vivès, Romain R, van den Born, Jacob

“…High dietary sodium aggravates renal disease by affecting blood pressure and by its recently shown pro-inflammatory and pro-fibrotic effects. Moreover,…”
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Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo by Campeiro, Joana Darc, Dam, Wendy, Monte, Gabriela Guilherme, Porta, Lucas Carvalho, Oliveira, Lilian Caroline Gonçalves de, Nering, Marcela Bego, Viana, Gustavo Monteiro, Carapeto, Fernando Cintra, Oliveira, Eduardo Brandt, van den Born, Jacob, Hayashi, Mirian A. F.

“…Activated proximal tubular epithelial cells (PTECs) play a crucial role in progressive tubulo-interstitial fibrosis in native and transplanted kidneys…”
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An observational study on intracutaneous sodium storage in intensive care patients and controls by van IJzendoorn, Marjolein, van den Born, Jacob, Hijmans, Ryanne, Bodde, Rianne, Buter, Hanneke, Dam, Wendy, Kingma, Peter, Maes, Gwendolyn, van der Veen, Tsjitske, Zijlstra, Wierd, Dijkstra, Baukje, Navis, Gerjan, Boerma, Christiaan

“…The development of ICU-acquired sodium disturbances is not fully understood. Alterations in non-osmotic skin sodium storage, hypothetically…”
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Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells by Campeiro, Joana D'Arc, Dam, Wendy A, Hayashi, Mirian A F, van den Born, Jacob

“…Proteinuria drives progressive tubulointerstitial fibrosis in native and transplanted kidneys, mainly through the activation of proximal tubular epithelial…”
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Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20 by Lammerts, Rosa G M, Talsma, Ditmer T, Dam, Wendy A, Daha, Mohamed R, Seelen, Marc A J, Berger, Stefan P, van den Born, Jacob

“…Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin…”
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