Search Results - "Jacob, Richard E."

Comparative Risks of Aldehyde Constituents in Cigarette Smoke Using Transient Computational Fluid Dynamics/Physiologically Based Pharmacokinetic Models of the Rat and Human Respiratory Tracts by Corley, Richard A, Kabilan, Senthil, Kuprat, Andrew P, Carson, James P, Jacob, Richard E, Minard, Kevin R, Teeguarden, Justin G, Timchalk, Charles, Pipavath, Sudhakar, Glenny, Robb, Einstein, Daniel R

“…Computational fluid dynamics (CFD) modeling is well suited for addressing species-specific anatomy and physiology in calculating respiratory tissue exposures…”
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Machine learning for ultrasonic nondestructive examination of welding defects: A systematic review by Sun, Hongbin, Ramuhalli, Pradeep, Jacob, Richard E.

“…Recent years have seen a substantial increase in the application of machine learning (ML) for automated analysis of nondestructive examination (NDE) data. One…”
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Dynamic multiscale boundary conditions for 4D CT of healthy and emphysematous rats by Jacob, Richard E, Carson, James P, Thomas, Mathew, Einstein, Daniel R

“…Changes in the shape of the lung during breathing determine the movement of airways and alveoli, and thus impact airflow dynamics. Modeling airflow dynamics in…”
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In vivo MRI of altered proton signal intensity and T2 relaxation in a bleomycin model of pulmonary inflammation and fibrosis by Jacob, Richard E., Amidan, Brett G., Soelberg, Jolen, Minard, Kevin R.

“…Purpose: To investigate the ability of proton (1H) magnetic resonance imaging (MRI) to distinguish between pulmonary inflammation and fibrosis. Materials and…”
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Stable small animal ventilation for dynamic lung imaging to support computational fluid dynamics models by Jacob, Richard E, Lamm, Wayne J

“…Pulmonary computational fluid dynamics models require that three-dimensional images be acquired over multiple points in the dynamic breathing cycle without…”
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Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice by Jacob, Richard E, Carson, James P, Gideon, Kathy M, Amidan, Brett G, Smith, Cathie L, Lee, K Monica

“…In this work, we compare two methods for evaluating and quantifying pulmonary airspace enlargement in a mouse model of chronic cigarette smoke exposure…”
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Detecting Radiation-Induced Injury Using Rapid 3D Variogram Analysis of CT Images of Rat Lungs by Jacob, Richard E., PhD, Murphy, Mark K., MS, Creim, Jeffrey A., BS, Carson, James P., PhD

“…Rationale and Objectives To investigate the ability of variogram analysis of octree-decomposed computed tomography (CT) images and volume change maps to detect…”
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Development and testing of coarse-grained models for ultrasonic simulations of cast austenitic stainless steel by Jacob, Richard E., Prowant, Matthew S., Hutchinson, Chris A.

“…•A method for developing models of realistic CASS microstructure is shown.•Simulated sound fields in CASS models agree well with experimental sound…”
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Phase-contrast MRI and CFD modeling of apparent 3He gas flow in rat pulmonary airways by Minard, Kevin R., Kuprat, Andrew P., Kabilan, Senthil, Jacob, Richard E., Einstein, Daniel R., Carson, James P., Corley, Richard A.

“…[Display omitted] ► 3He MRI and CFD are complimentary tools for studying inhaled gas dynamics. ► PC-MRI provides apparent values of 3He gas velocity. ► Depend…”
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Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human by Corley, Richard A, Kabilan, Senthil, Kuprat, Andrew P, Carson, James P, Minard, Kevin R, Jacob, Richard E, Timchalk, Charles, Glenny, Robb, Pipavath, Sudhakar, Cox, Timothy, Wallis, Christopher D, Larson, Richard F, Fanucchi, Michelle V, Postlethwait, Edward M, Einstein, Daniel R

“…Computational fluid dynamics (CFD) models are useful for predicting site-specific dosimetry of airborne materials in the respiratory tract and elucidating the…”
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Anatomical Details of the Rabbit Nasal Passages and Their Implications in Breathing, Air Conditioning, and Olfaction by Xi, Jinxiang, Si, Xiuhua A., Kim, Jongwon, Zhang, Yu, Jacob, Richard E., Kabilan, Senthil, Corley, Richard A.

“…ABSTRACT The rabbit is commonly used as a laboratory animal for inhalation toxicology tests and detail knowledge of the rabbit airway morphometry is needed for…”
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Development of a Zealand white rabbit deposition model to study inhalation anthrax by Asgharian, Bahman, Price, Owen, Kabilan, Senthil, Jacob, Richard E., Einstein, Daniel R., Kuprat, Andrew P., Corley, Richard A.

“…Despite using rabbits in several inhalation exposure experiments to study diseases such as anthrax, there is a lack of understanding regarding deposition…”
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Comparison of realistic and idealized breathing patterns in computational models of airflow and vapor dosimetry in the rodent upper respiratory tract by Colby, Sean M., Kabilan, Senthil, Jacob, Richard E., Kuprat, Andrew P., Einstein, Daniel R., Corley, Richard A.

“…Context: Computational fluid dynamics (CFD) simulations of airflows coupled with physiologically based pharmacokinetic (PBPK) modeling of respiratory tissue…”
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Automated measurement of heterogeneity in CT images of healthy and diseased rat lungs using variogram analysis of an octree decomposition by Jacob, Richard E, Carson, James P

“…Assessing heterogeneity in lung images can be an important diagnosis tool. We present a novel and objective method for assessing lung damage in a rat model of…”
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Respiratory tract lung geometry and dosimetry model for male Sprague-Dawley rats by Miller, Frederick J., Asgharian, Bahman, Schroeter, Jeffry D., Price, Owen, Corley, Richard A., Einstein, Daniel R., Jacob, Richard E., Cox, Timothy C., Kabilan, Senthil, Bentley, Timothy

“…Abstract While inhalation toxicological studies of various compounds have been conducted using a number of different strains of rats, mechanistic dosimetry…”
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3D MRI of non-Gaussian (3)He gas diffusion in the rat lung by Jacob, Richard E, Laicher, Gernot, Minard, Kevin R

“…In (3)He magnetic resonance images of pulmonary air spaces, the confining architecture of the parenchymal tissue results in a non-Gaussian distribution of…”
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Comparison of CT-derived ventilation maps with deposition patterns of inhaled microspheres in rats by Jacob, Richard E., Lamm, Wayne J., Einstein, Daniel R., Krueger, Melissa A., Glenny, Robb W., Corley, Richard A.

“…ABSTRACTPurpose: Computer models for inhalation toxicology and drug-aerosol delivery studies rely on ventilation pattern inputs for predictions of particle…”
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In situ casting and imaging of the rat airway tree for accurate 3D reconstruction by Jacob, Richard E., Colby, Sean M., Kabilan, Senthil, Einstein, Daniel R., Carson, James P.

“…ABSTRACTThe use of anatomically accurate, animal-specific airway geometries is important for understanding and modeling the physiology of the respiratory…”
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Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysema by Gierada, David S, Woods, Jason C, Bierhals, Andrew J, Bartel, Seth T, Ritter, Jon H, Choong, Cliff K, Das, Nitin A, Hong, Cheng, Pilgram, Thomas K, Chang, Yulin V, Jacob, Richard E, Hogg, James C, Battafarano, Richard J, Cooper, Joel D, Meyers, Bryan F, Patterson, G Alexander, Yablonskiy, Dmitriy A, Conradi, Mark S

“…To characterize the effect of diffusion time on short-range hyperpolarized (3)He magnetic resonance imaging (MRI) diffusion measurements across a wide range of…”
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Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans by Asgharian, Bahman, Price, Owen, McClellan, Gene, Corley, Rick, Einstein, Daniel R., Jacob, Richard E., Harkema, Jack, Carey, Stephan A., Schelegle, Edward, Hyde, Dallas, Kimbell, Julia S., Miller, Frederick J.

“…The exposure-dose-response characterization of an inhalation hazard established in an animal species needs to be translated to an equivalent characterization…”
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