Search Results - "Jacob, Jan"

Transcriptomic and metabolomic data integration by Cavill, Rachel, Jennen, Danyel, Kleinjans, Jos, Briedé, Jacob Jan

“…Many studies now produce parallel data sets from different omics technologies; however, the task of interpreting the acquired data in an integrated fashion is…”
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Triplet Energy Transfer Mechanism in Copper Photocatalytic N‐ and O‐Methylation by Hoving, Martijn, Haaksma, Jacob‐Jan, Stoppel, Anne, Chronc, Lukas, Hoffmann, Jonas, Beil, Sebastian B.

“…Methylation reactions are chemically simple but challenging to perform under mild and non‐toxic conditions. A photochemical energy transfer strategy was merged…”
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Dynamic brain ADC variations over the cardiac cycle and their relation to tissue strain assessed with DENSE at high‐field MRI by Sloots, Jacob‐Jan, Froeling, Martijn, Biessels, Geert Jan, Zwanenburg, Jaco J. M.

“…Purpose The ADC of brain tissue slightly varies over the cardiac cycle. This variation could reflect physiology, including mixing of the interstitial fluid,…”
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Meta‐Ortho Effect on the Excited State Pathways of Chloroanilines by Nitu, Cristina, Wal, Jacob Jan, Kaul, Nidhi, Steen, Jorn D., Hammarström, Leif, Fagnoni, Maurizio, Crespi, Stefano

“…Direct excitation of aromatic compounds grants access to high‐energy intermediates that can be utilised in organic synthesis. Understanding and predicting the…”
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Front Cover: Meta‐Ortho Effect on the Excited State Pathways of Chloroanilines (Eur. J. Org. Chem. 1/2024) by Nitu, Cristina, Wal, Jacob Jan, Kaul, Nidhi, Steen, Jorn D., Hammarström, Leif, Fagnoni, Maurizio, Crespi, Stefano

“…The Front Cover shows the different rates at which the excited isomeric chloroanilines can reach their respective conical intersections for non‐radiative…”
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Fluorescence lifetime imaging microscopy of flexible and rigid dyes probes the biophysical properties of synthetic and biological membranes by Lira, Rafael B, Dillingh, Laura S, Schuringa, Jan-Jacob, Yahioglu, Gokhan, Suhling, Klaus, Roos, Wouter H

“…Sensing of the biophysical properties of membranes using molecular reporters has recently regained widespread attention. This was elicited by the development…”
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Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability by Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Geugien, Marjan, Cunningham, Alan, Pruis, Maurien G., Weinhäuser, Isabel, Gerding, Albert, Bakker, Barbara M., Wierenga, Albertus T. J., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob

“…Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but…”
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Oxidative Stress, DNA Damage, and Inflammation Induced by Ambient Air and Wood Smoke Particulate Matter in Human A549 and THP-1 Cell Lines by Danielsen, Pernille Høgh, Møller, Peter, Jensen, Keld Alstrup, Sharma, Anoop Kumar, Wallin, Håkan, Bossi, Rossana, Autrup, Herman, Mølhave, Lars, Ravanat, Jean-Luc, Briedé, Jacob Jan, de Kok, Theo Martinus, Loft, Steffen

“…Combustion of biomass and wood for residential heating and/or cooking contributes substantially to both ambient air and indoor levels of particulate matter…”
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Forest fires as potential triggers for production and mobilization of polycyclic aromatic hydrocarbons to the terrestrial ecosystem by Campos, Isabel, Abrantes, Nelson, Pereira, Patrícia, Micaelo, Ana Cristina, Vale, Carlos, Keizer, Jan Jacob

“…Although forest fires have been identified as an important source of polycyclic aromatic hydrocarbons (PAHs), this problematic has not been thoroughly studied…”
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The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis by De Boer, Bauke, Sheveleva, Sofia, Apelt, Katja, Vellenga, Edo, Mulder, André B, Huls, Gerwin, Jacob Schuringa, Jan

“…Upregulation of the plasma membrane receptor IL1RAP in Acute Myeloid Leukemia (AML) has been reported but its role in the context of the leukemic bone marrow…”
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Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI by Sloots, Jacob Jan, Biessels, Geert Jan, Zwanenburg, Jaco J.M.

“…Microvascular blood volume pulsations due to the cardiac and respiratory cycles induce brain tissue deformation and, as such, are considered to drive the…”
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Beyond market failure: rationales for regional governmental venture capital by Vogelaar, Jan Jacob, Stam, Erik

“…Why do regional governments establish venture capital funds? Government intervention in venture capital markets is traditionally legitimised by market failure…”
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The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia by Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Cortés, Roldán, Cunningham, Alan, Pruis, Maurien G., de Boer, Bauke, van den Heuvel, Fiona A. J., Geugien, Marjan, Wierenga, Albertus T. J., Brouwers-Vos, Annet Z., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob

“…Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate…”
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Upper Ocean Responses to the Tropical Cyclones Ida and Felicia (2021) in the Gulf of Mexico and the Eastern North Pacific by Neun, Sebastian, Jacob, Jan, Wurl, Oliver

“…Tropical cyclones (TCs) are a significant component of ocean–atmosphere interactions and the climate system. These interactions determine both the development…”
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DTW4Omics: comparing patterns in biological time series by Cavill, Rachel, Kleinjans, Jos, Briedé, Jacob-Jan

“…When studying time courses of biological measurements and comparing these to other measurements eg. gene expression and phenotypic endpoints, the analysis is…”
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Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis by van den Boom, Vincent, Maat, Henny, Geugien, Marjan, Rodríguez López, Aida, Sotoca, Ana M., Jaques, Jennifer, Brouwers-Vos, Annet Z., Fusetti, Fabrizia, Groen, Richard W.J., Yuan, Huipin, Martens, Anton C.M., Stunnenberg, Hendrik G., Vellenga, Edo, Martens, Joost H.A., Schuringa, Jan Jacob

“…Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here, we find that…”
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Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock by Azkanaz, Maria, Rodríguez López, Aida, de Boer, Bauke, Huiting, Wouter, Angrand, Pierre-Olivier, Vellenga, Edo, Kampinga, Harm H, Bergink, Steven, Martens, Joost Ha, Schuringa, Jan Jacob, van den Boom, Vincent

“…Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed…”
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Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI by Sloots, Jacob Jan, Biessels, Geert Jan, de Luca, Alberto, Zwanenburg, Jaco J.M.

“…•Cardiac-induced 3D brain tissue strain tensor measured using MRI.•Single-shot simultaneous multi-slice DENSE MRI is suitable to acquire tissue strain for…”
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A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers by Bonardi, Francesco, Fusetti, Fabrizia, Deelen, Patrick, van Gosliga, Djoke, Vellenga, Edo, Schuringa, Jan Jacob

“…Interactions between hematopoietic stem cells and their niche are mediated by proteins within the plasma membrane (PM) and changes in these interactions might…”
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Innovations, challenges, and minimal information for standardization of humanized mice by Stripecke, Renata, Münz, Christian, Schuringa, Jan Jacob, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, Shultz, Leonard

“…Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary…”
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