Search Results - "Jacob, H"

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues by Hanna, Jacob H., Saha, Krishanu, Jaenisch, Rudolf

“…Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions…”
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SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate by Irie, Naoko, Weinberger, Leehee, Tang, Walfred W.C., Kobayashi, Toshihiro, Viukov, Sergey, Manor, Yair S., Dietmann, Sabine, Hanna, Jacob H., Surani, M. Azim

“…Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, without a tractable experimental model, the mechanism of…”
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Complete genome, catabolic sub-proteomes and key-metabolites of Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading, sulfate-reducing bacterium by Wöhlbrand, Lars, Jacob, Jacob H., Kube, Michael, Mussmann, Marc, Jarling, René, Beck, Alfred, Amann, Rudolf, Wilkes, Heinz, Reinhardt, Richard, Rabus, Ralf

“…Summary Among the dominant deltaproteobacterial sulfate‐reducing bacteria (SRB), members of the genus Desulfobacula are not only present in (hydrocarbon‐rich)…”
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Driver Gene Mutations and Epigenetics in Colorectal Cancer by Raskov, Hans, Søby, Jacob H., Troelsen, Jesper, Bojesen, Rasmus D., Gögenur, Ismail

“…OBJECTIVE:The majority of patients with colorectal cancer are diagnosed with locally advanced and/or disseminated disease, and treatment options include…”
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Human brain organoids on a chip reveal the physics of folding by Karzbrun, Eyal, Kshirsagar, Aditya, Cohen, Sidney R., Hanna, Jacob H., Reiner, Orly

“…Human brain wrinkling has been implicated in neurodevelopmental disorders and yet its origins remain unknown. Polymer gel models suggest that wrinkling emerges…”
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Surface- vs Diffusion-Limited Mechanisms of Anion Exchange in CsPbBr3 Nanocrystal Cubes Revealed through Kinetic Studies by Koscher, Brent A, Bronstein, Noah D, Olshansky, Jacob H, Bekenstein, Yehonadav, Alivisatos, A. Paul

“…Ion-exchange transformations allow access to nanocrystalline materials with compositions that are inaccessible via direct synthetic routes. However, additional…”
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Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling by Garcia-Campos, Miguel Angel, Edelheit, Sarit, Toth, Ursula, Safra, Modi, Shachar, Ran, Viukov, Sergey, Winkler, Roni, Nir, Ronit, Lasman, Lior, Brandis, Alexander, Hanna, Jacob H., Rossmanith, Walter, Schwartz, Schraga

“…N6-methyladenosine (m6A) is the most abundant modification on mRNA and is implicated in critical roles in development, physiology, and disease. A major…”
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The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy by Dorn, Lisa E, Lasman, Lior, Chen, Jing, Xu, Xianyao, Hund, Thomas J, Medvedovic, Mario, Hanna, Jacob H, van Berlo, Jop H, Accornero, Federica

“…BACKGROUND:N-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA. The role of m6A mRNA…”
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Neuronal activity biases axon selection for myelination in vivo by Hines, Jacob H, Ravanelli, Andrew M, Schwindt, Rani, Scott, Ethan K, Appel, Bruce

“…Using zebrafish, the authors show that neuronal activity influences which axons are selected for myelination by promoting the growth and stability of…”
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Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs by Tarazi, Shadi, Aguilera-Castrejon, Alejandro, Joubran, Carine, Ghanem, Nadir, Ashouokhi, Shahd, Roncato, Francesco, Wildschutz, Emilie, Haddad, Montaser, Oldak, Bernardo, Gomez-Cesar, Elidet, Livnat, Nir, Viukov, Sergey, Lokshtanov, Dmitry, Naveh-Tassa, Segev, Rose, Max, Hanna, Suhair, Raanan, Calanit, Brenner, Ori, Kedmi, Merav, Keren-Shaul, Hadas, Lapidot, Tsvee, Maza, Itay, Novershtern, Noa, Hanna, Jacob H.

“…In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic or extraembryonic tissues after microinjection into…”
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Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade by Wei, Spencer C., Levine, Jacob H., Cogdill, Alexandria P., Zhao, Yang, Anang, Nana-Ama A.S., Andrews, Miles C., Sharma, Padmanee, Wang, Jing, Wargo, Jennifer A., Pe’er, Dana, Allison, James P.

“…Immune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we lack a satisfying comprehension of the underlying…”
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Putting together pieces of the LIN28A pathway puzzle by Yilmaz, Alperen, Gurhan, Gulben, Hanna, Jacob H.

“…Two recent studies provide mechanistic insights into how LIN28A controls changes in cell fate identity, focusing on either a let-7-independent or…”
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Kepler-discovered Multiple-planet Systems near Period Ratios Suggestive of Mean-motion Resonances Are Young by Hamer, Jacob H., Schlaufman, Kevin C.

“…Abstract Before the launch of the Kepler Space Telescope, models of low-mass planet formation predicted that convergent type I migration would often produce…”
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Framework of Affordances for Virtual Reality and Augmented Reality by Steffen, Jacob H., Gaskin, James E., Meservy, Thomas O., Jenkins, Jeffrey L., Wolman, Iopa

“…Virtual reality (VR) and augmented reality (AR) technologies continue to grow and present possibilities to change the ways we learn, accomplish tasks, and…”
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Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies by Wei, Spencer C., Anang, Nana-Ama A. S., Sharma, Roshan, Andrews, Miles C., Reuben, Alexandre, Levine, Jacob H., Cogdill, Alexandria P., Mancuso, James J., Wargo, Jennifer A., Pe’er, Dana, Allison, James P.

“…Immune checkpoint blockade therapy targets T cell-negative costimulatory molecules such as cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell…”
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M5-branes wrapped on four-dimensional orbifolds by Cheung, K. C. Matthew, Fry, Jacob H. T., Gauntlett, Jerome P., Sparks, James

“…A bstract We construct supersymmetric AdS 3 solutions of D = 11 supergravity, dual to d = 2, N = (0 , 2) SCFTs, that are associated with M5-branes wrapping two…”
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General Principles and Strategies for Salting-Out Informed by the Hofmeister Series by Hyde, Alan M, Zultanski, Susan L, Waldman, Jacob H, Zhong, Yong-Li, Shevlin, Michael, Peng, Feng

“…Overarching principles for salting-out extraction are long-established but poorly disseminated. We highlight the opportunity for more widespread application of…”
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The Role of m6A/m-RNA Methylation in Stress Response Regulation by Engel, Mareen, Eggert, Carola, Kaplick, Paul M., Eder, Matthias, Röh, Simone, Tietze, Lisa, Namendorf, Christian, Arloth, Janine, Weber, Peter, Rex-Haffner, Monika, Geula, Shay, Jakovcevski, Mira, Hanna, Jacob H., Leshkowitz, Dena, Uhr, Manfred, Wotjak, Carsten T., Schmidt, Mathias V., Deussing, Jan M., Binder, Elisabeth B., Chen, Alon

“…N6-methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of…”
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Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis by Levine, Jacob H., Simonds, Erin F., Bendall, Sean C., Davis, Kara L., Amir, El-ad D., Tadmor, Michelle D., Litvin, Oren, Fienberg, Harris G., Jager, Astraea, Zunder, Eli R., Finck, Rachel, Gedman, Amanda L., Radtke, Ina, Downing, James R., Pe’er, Dana, Nolan, Garry P.

“…Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells, often within the same patient. Intratumor phenotypic and functional…”
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Evolutionary Origins of the Oligodendrocyte Cell Type and Adaptive Myelination by Hines, Jacob H

“…Oligodendrocytes are multifunctional central nervous system (CNS) glia that are essential for neural function in gnathostomes. The evolutionary origins and…”
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