Search Results - "Jacob, George"

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology by Eslam, Mohammed, George, Jacob

“…Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population, paralleling worldwide increases in obesity and metabolic syndrome…”
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Adding to the confusion in more than just the name by George, Jacob

“…Subsequent years have seen more than 4,000 citations for the two sentinel papers, over 7,000 publications using the MAFLD terminology and definition, and…”
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Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis by Younossi, Zobair, Tacke, Frank, Arrese, Marco, Chander Sharma, Barjesh, Mostafa, Ibrahim, Bugianesi, Elisabetta, Wai‐Sun Wong, Vincent, Yilmaz, Yusuf, George, Jacob, Fan, Jiangao, Vos, Miriam B

“…Over the past 2 decades, nonalcoholic fatty liver disease (NAFLD) has grown from a relatively unknown disease to the most common cause of chronic liver disease…”
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TREM2 as an evolving therapeutic target in Alzheimer's disease by George, Jacob

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Genetic Insights for Drug Development in NAFLD by Eslam, Mohammed, George, Jacob

“…Drug development is a costly, time-consuming, and challenging endeavour, with only a few agents reaching the threshold of approval for clinical use. Therefore,…”
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Cytokines: From Clinical Significance to Quantification by Liu, Chao, Chu, Dewei, Kalantar‐Zadeh, Kourosh, George, Jacob, Young, Howard A., Liu, Guozhen

“…Cytokines are critical mediators that oversee and regulate immune and inflammatory responses via complex networks and serve as biomarkers for many diseases…”
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The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by Kazankov, Konstantin, Jørgensen, Simon Mark Dahl, Thomsen, Karen Louise, Møller, Holger Jon, Vilstrup, Hendrik, George, Jacob, Schuppan, Detlef, Grønbæk, Henning

“…Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype nonalcoholic steatohepatitis (NASH) are becoming the leading cause…”
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MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach by Tsutsumi, Tsubasa, Eslam, Mohammed, Kawaguchi, Takumi, Yamamura, Sakura, Kawaguchi, Atsushi, Nakano, Dan, Koseki, Masahiro, Yoshinaga, Shinobu, Takahashi, Hirokazu, Anzai, Keizo, George, Jacob, Torimura, Takuji

“…Aim Metabolic associated fatty liver disease (MAFLD) partly overlaps with non‐alcoholic fatty liver disease (NAFLD). Thus, using a generalized estimating…”
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MAFLD: How is it different from NAFLD? by Gofton, Cameron, Upendran, Yadhavan, Zheng, Ming-Hua, George, Jacob

“…"Metabolic dysfunction-associated fatty liver disease (MAFLD)" is the term suggested in 2020 to refer to fatty liver disease related to systemic metabolic…”
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MAFLD identifies patients with significant hepatic fibrosis better than NAFLD by Yamamura, Sakura, Eslam, Mohammed, Kawaguchi, Takumi, Tsutsumi, Tsubasa, Nakano, Dan, Yoshinaga, Shinobu, Takahashi, Hirokazu, Anzai, Keizo, George, Jacob, Torimura, Takuji

“…Background & Aims Diagnostic criteria for metabolic associated fatty liver disease (MAFLD) have been proposed, but not validated. We aimed to compare the…”
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Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention by Younossi, Zobair, Anstee, Quentin M., Marietti, Milena, Hardy, Timothy, Henry, Linda, Eslam, Mohammed, George, Jacob, Bugianesi, Elisabetta

“…Key Points As a consequence of the pandemic spread of obesity, NAFLD is one of the most important causes of liver disease worldwide in adults and children,…”
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Adding to the confusion in more than just the name by Jacob George

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Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation by Chen, Fei, Esmaili, Saeed, Rogers, Geraint B., Bugianesi, Elisabetta, Petta, Salvatore, Marchesini, Giulio, Bayoumi, Ali, Metwally, Mayada, Azardaryany, Mahmoud Karimi, Coulter, Sally, Choo, Jocelyn M., Younes, Ramy, Rosso, Chiara, Liddle, Christopher, Adams, Leon A., Craxì, Antonio, George, Jacob, Eslam, Mohammed

“…Background and Aims Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population. A significant subset of patients are lean, but their…”
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Role of nanomaterials in water treatment applications: A review by Santhosh, Chella, Velmurugan, Venugopal, Jacob, George, Jeong, Soon Kwan, Grace, Andrews Nirmala, Bhatnagar, Amit

“…•Use of nanomaterials (NMs) in water treatment has been reviewed.•Carbon nanomaterials, nano metal oxides and nano composites are reviewed.•Adsorption,…”
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Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells by Huo, Xiaoqi, Han, Shuanglin, Wu, Guang, Latchoumanin, Olivier, Zhou, Gang, Hebbard, Lionel, George, Jacob, Qiao, Liang

“…Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with…”
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Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models by Fassler, Michael, Rappaport, Maya Saban, Cuño, Clara Benaim, George, Jacob

“…Genetic variants and mutations in triggering receptor expressed in myeloid cells (TREM2) are associated with premature and late onset Alzheimer's disease (AD)…”
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MAFLD enhances clinical practice for liver disease in the Asia-Pacific region by Kawaguchi, Takumi, Tsutsumi, Tsubasa, Nakano, Dan, Eslam, Mohammed, George, Jacob, Torimura, Takuji

“…Fatty liver is now a major cause of liver disease in the Asia-Pacific region. Liver diseases in this region have distinctive characteristics. First, fatty…”
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Developing liver organoids from induced pluripotent stem cells (iPSCs): An alternative source of organoid generation for liver cancer research by Nguyen, Romario, Da Won Bae, Sarah, Qiao, Liang, George, Jacob

“…Primary liver cancer (PLC) represents a significant proportion of all human cancers and constitutes a substantial health and economic burden to society…”
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Single cell RNA-seq analysis identifies a noncoding RNA mediating resistance to sorafenib treatment in HCC by Zhou, Kevin, Nguyen, Romario, Qiao, Liang, George, Jacob

“…Despite showing upregulation of stemness/EMT genes, Huh7-R cells showed downregulation of the proliferative marker MKI67, and cell-cycle related genes (Fig…”
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Nonalcoholic fatty liver disease burden: Australia, 2019–2030 by Adams, Leon A, Roberts, Stuart K, Strasser, Simone I, Mahady, Suzanne E, Powell, Elizabeth, Estes, Chris, Razavi, Homie, George, Jacob

“…Background and Aim Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) account for a large and growing proportion of liver disease…”
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