Search Results - "Jacob, D."

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval by Hwang, Duhyeong, Ramsey, Jacob D., Kabanov, Alexander V.

“…Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly…”
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Bacterial species rarely work together by Palmer, Jacob D, Foster, Kevin R

“…Competition is prevalent and could be harnessed as an alternative to antibiotics…”
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Monopoly without a Monopolist: An Economic Analysis of the Bitcoin Payment System by Huberman, Gur, Leshno, Jacob D, Moallemi, Ciamac

“…Abstract Bitcoin provides its users with transaction-processing services which are similar to those of traditional payment systems. This article models the…”
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A Supply and Demand Framework for Two-Sided Matching Markets by Azevedo, Eduardo M., Leshno, Jacob D.

“…This paper develops a price-theoretic framework for matching markets with heterogeneous preferences. The model departs from the Gale and Shapley model by…”
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BlendMol: advanced macromolecular visualization in Blender by Durrant, Jacob D

“…Programs such as VMD and PyMOL are excellent tools for analyzing macromolecular structures, but they do not implement many of the advanced rendering techniques…”
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Intrinsic ecological dynamics drive biodiversity turnover in model metacommunities by O’Sullivan, Jacob D., Terry, J. Christopher D., Rossberg, Axel G.

“…Turnover of species composition through time is frequently observed in ecosystems. It is often interpreted as indicating the impact of changes in the…”
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Molecular dynamics simulations and drug discovery by Durrant, Jacob D, McCammon, J Andrew

“…This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule…”
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Nonhuman primate models of human viral infections by Estes, Jacob D., Wong, Scott W., Brenchley, Jason M.

“…Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with…”
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Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model by Zhang, Yan, Tan, Hui, Daniels, Jacob D, Zandkarimi, Fereshteh, Liu, Hengrui, Brown, Lewis M, Uchida, Koji, O'Connor, Owen A, Stockwell, Brent R

“…Ferroptosis is a form of regulated cell death that can be induced by inhibition of the cystine-glutamate antiporter, system x . Among the existing system x…”
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Metacommunity‐scale biodiversity regulation and the self‐organised emergence of macroecological patterns by O’Sullivan, Jacob D., Knell, Robert J., Rossberg, Axel G., He, Fangliang

“…There exist a number of key macroecological patterns whose ubiquity suggests that the spatio‐temporal structure of ecological communities is governed by some…”
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The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19–infected patients by Treon, Steven P., Castillo, Jorge J., Skarbnik, Alan P., Soumerai, Jacob D., Ghobrial, Irene M., Guerrera, Maria Luisa, Meid, Kirsten, Yang, Guang

“…Treon et al provide early clinical data supporting a theoretical rationale for continuing ibrutinib in patients receiving the drug during COVID-19 illness…”
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Sustainable Development Goals and progressive business models for economic transformation by Rendtorff, Jacob D

“…This paper analyses the Sustainable Development Goals of the United Nations in the 2030 ‘Transforming the World’ Agenda, from 2015, as a contribution to…”
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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation by Gaschler, Michael M., Andia, Alexander A., Liu, Hengrui, Csuka, Joleen M., Hurlocker, Brisa, Vaiana, Christopher A., Heindel, Daniel W., Zuckerman, Dylan S., Bos, Pieter H., Reznik, Eduard, Ye, Ling F., Tyurina, Yulia Y., Lin, Annie J., Shchepinov, Mikhail S., Chan, Amy Y., Peguero-Pereira, Eveliz, Fomich, Maksim A., Daniels, Jacob. D., Bekish, Andrei V., Shmanai, Vadim V., Kagan, Valerian E., Mahal, Lara K., Woerpel, K. A., Stockwell, Brent R.

“…Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO 2 is an…”
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Case 16-2022: A Man with Fevers, Night Sweats, and a Mediastinal Mass. Reply by Soumerai, Jacob D

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Migraine Progression: A Systematic Review by Buse, Dawn C., Greisman, Jacob D., Baigi, Khosrow, Lipton, Richard B.

“…Background Migraine is a common and often debilitating neurological disease. It can be divided into episodic and chronic subforms based on the number of…”
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THE DEAD HAND OF A SILENT PAST: BRUEN, GUN RIGHTS, AND THE SHACKLES OF HISTORY by Charles, Jacob D

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Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues by Estes, Jacob D.

“…Summary Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human…”
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NNScore 2.0: A Neural-Network Receptor–Ligand Scoring Function by Durrant, Jacob D, McCammon, J. Andrew

“…NNScore is a neural-network-based scoring function designed to aid the computational identification of small-molecule ligands. While the test cases included in…”
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Webina: an open-source library and web app that runs AutoDock Vina entirely in the web browser by Kochnev, Yuri, Hellemann, Erich, Cassidy, Kevin C, Durrant, Jacob D

“…Abstract Motivation Molecular docking is a computational technique for predicting how a small molecule might bind a macromolecular target. Among docking…”
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POVME 2.0: An Enhanced Tool for Determining Pocket Shape and Volume Characteristics by Durrant, Jacob D, Votapka, Lane, Sørensen, Jesper, Amaro, Rommie E

“…Analysis of macromolecular/small-molecule binding pockets can provide important insights into molecular recognition and receptor dynamics. Since its release in…”
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