Search Results - "Jackson Rudd, Deanne"

Single Oral Doses of MK-8507, a Novel Non-Nucleoside Reverse Transcriptase Inhibitor, Suppress HIV-1 RNA for a Week by Schürmann, Dirk, Jackson Rudd, Deanne, Schaeffer, Andrea, De Lepeleire, Inge, Friedman, Evan J., Robberechts, Martine, Zhang, Saijuan, Liu, Yang, Kandala, Bhargava, Keicher, Christian, Däumer, Martin, Hofmann, Jörg, Grobler, Jay A., Stoch, S. Aubrey, Iwamoto, Marian, Ankrom, Wendy

“…MK-8507 is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor being developed for treatment of HIV-1 infection. MK-8507 has high antiviral potency in…”
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Leveraging patient‐centric sampling for clinical drug development and decentralized clinical trials: Promise to reality by Maass, Katie F., Barfield, Matthew D., Ito, Mototsugu, James, Christopher A., Kavetska, Olga, Kozinn, Marc, Kumar, Parag, Lepak, Maureen, Leuthold, Luc Alexis, Li, Wenkui, Mikhailov, Dmitri, Patel, Shefali, Perez, Nisha L., Jackson Rudd, Deanne, Vakkalagadda, Blisse, Williams, Tracy M., Zha, Jiuhong, Zhang, Xin, Anderson, Melanie D.

“…Advances in the technologies to enable patient‐centric sampling (PCS) have the potential to improve blood sample collection by enabling clinical trial…”
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Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV by Ankrom, Wendy, Jackson Rudd, Deanne, Schaeffer, Andrea, Panebianco, Deborah, Friedman, Evan J, Tomek, Charles, Stoch, S Aubrey, Iwamoto, Marian

“…MK-8507 is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor in clinical development with potential for once-weekly oral administration for the…”
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A Phase 1 Trial to Evaluate the Relationship Between Fluoride Intake and Urinary Fluoride Excretion in Healthy Participants by Gillespie, Gillian, Jackson Rudd, Deanne, Zhang, Saijuan, Schaeffer, Andrea, Tomek, Charles, Larson, Patrick, Stoch, S. Aubrey, Iwamoto, Marian

“…Chronic overexposure to fluoride can have deleterious effects in the musculoskeletal system. Some fluorine‐containing therapeutics, such as voriconazole,…”
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Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK‐8507, an Investigational, Oral, Once‐Weekly Nonnucleoside Reverse Transcriptase Inhibitor by Gillespie, Gillian, Jackson Rudd, Deanne, Zhang, Saijuan, Schaeffer, Andrea, Tomek, Charles, Larson, Patrick, Stoch, S. Aubrey, Iwamoto, Marian

“…MK‐8507 is an investigational HIV‐1 nonnucleoside reverse transcriptase inhibitor being developed for the treatment of HIV‐1 infection. MK‐8507 contains 2…”
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Safety and Pharmacokinetics of Once-Daily Multiple-Dose Administration of Islatravir in Adults Without HIV by Matthews, Randolph P., Jackson Rudd, Deanne, Zhang, Saijuan, Fillgrove, Kerry L., Sterling, Laura M., Grobler, Jay A., Vargo, Ryan C., Stoch, S. Aubrey, Iwamoto, Marian

“…Islatravir (MK-8591) is a novel nucleoside analog in development for the treatment and prevention of HIV-1 infection. Islatravir has potent antiviral activity…”
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Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV by Matthews, Randolph P., Ankrom, Wendy, Friedman, Evan, Jackson Rudd, Deanne, Liu, Yang, Mogg, Robin, Panebianco, Deborah, De Lepeleire, Inge, Petkova, Magdalena, Grobler, Jay A., Stoch, Selwyn Aubrey, Iwamoto, Marian

“…Islatravir (MK‐8591) is a nucleoside analogue in development for the treatment and prevention of HIV‐1. Two phase 1 trials were conducted during initial…”
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A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV by Matthews, Randolph P., Jackson Rudd, Deanne, Fillgrove, Kerry L., Zhang, Saijuan, Tomek, Charles, Stoch, S. Aubrey, Iwamoto, Marian

“…Background and Objectives Islatravir (MK-8591) is a novel nucleoside analogue in development for the treatment and prevention of HIV-1 infection. Doravirine is…”
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A phase 1, open‐label study to evaluate the drug interaction between islatravir (MK‐8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females by Ankrom, Wendy, Jackson Rudd, Deanne, Zhang, Saijuan, Fillgrove, Kerry L., Gravesande, Kezia N., Matthews, Randolph P., Brimhall, Darin, Stoch, S. Aubrey, Iwamoto, Marian N.

“…Introduction Hormonal contraceptives are among the most effective forms of reversible contraception, but many other compounds, including some antiretrovirals,…”
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Tyrosinase Reactivity in a Model Complex: An Alternative Hydroxylation Mechanism by Mirica, Liviu M, Vance, Michael, Rudd, Deanne Jackson, Hedman, Britt, Hodgson, Keith O, Solomon, Edward I, Stack, T. Daniel P

“…The binuclear copper enzyme tyrosinase activates O₂ to form a [micro]-[eta]²:[eta]²-peroxodicopper(II) complex, which oxidizes phenols to catechols. Here, a…”
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Sulfur K-Edge X-ray Absorption Spectroscopy as a Probe of Ligand−Metal Bond Covalency:  Metal vs Ligand Oxidation in Copper and Nickel Dithiolene Complexes by Sarangi, Ritimukta, DeBeer George, Serena, Rudd, Deanne Jackson, Szilagyi, Robert K, Ribas, Xavi, Rovira, Concepció, Almeida, Manuel, Hodgson, Keith O, Hedman, Britt, Solomon, Edward I

“…A combination of Cu L-edge and S K-edge X-ray absorption data and density functional theory (DFT) calculations has been correlated with 33S electron…”
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Lack of a Clinically Meaningful Drug Interaction Between the HIV‐1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate by Rudd, Deanne Jackson, Zhang, Saijuan, Fillgrove, Kerry L., Fox‐Bosetti, Sabrina, Matthews, Randolph P., Friedman, Evan, Armas, Danielle, Stoch, S. Aubrey, Iwamoto, Marian

“…Islatravir, an investigational nucleoside reverse transcriptase translocation inhibitor, is in clinical development for the treatment and prevention of HIV‐1…”
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Toward highly sensitive and reproducible LC-MS/MS analysis of MK-8591 phosphorylated anabolites in human peripheral blood mononuclear cells by Sun, Li, Chavez-Eng, Cynthia, Fillgrove, Kerry L, Lu, Bing, Xie, Iris, Rudd, Deanne Jackson, Breidinger, Sheila, Anderson, Melanie, Yeh, Suzie, Zhang, Rena, Woolf, Eric J

“…MK-8591 (EFdA), a novel anti-HIV nucleoside analog, is converted to mono-, di- and tri-phosphates (MK-8591-MP, MK-8591-DP and MK-8591-TP) intracellularly,…”
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P2 A single monotherapy dose of MK-8591, a novel NRTI, suppresses HIV for 10 days by Martine Robberechts, Evan J. Friedman, Dirk Schürmann, Deanne Jackson Rudd, Inge De Lepeleire, Sabrina Fox-Bosetti, Sandra Zhang, Andreas Huser, Daria Hazuda, Marian Iwamoto, JayA Grobler

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X-ray Absorption Spectroscopic Investigation of the Spin-Transition Character in a Series of Single-Site Perturbed Iron(II) Complexes by Rudd, Deanne Jackson, Goldsmith, Christian R., Cole, Adam P., Stack, T. Daniel P., Hodgson, Keith O., Hedman, Britt

“…Select ferrous spin-transition complexes with the pentadentate ligand 2,6-bis(bis(2-pyridyl)methoxymethane)pyridine (PY5) were examined using…”
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Reversible O−O Bond Cleavage in Copper−Dioxygen Isomers:  Impact of Anion Basicity by Ottenwaelder, Xavier, Rudd, Deanne Jackson, Corbett, Mary C, Hodgson, Keith O, Hedman, Britt, Stack, T. Daniel P

“…Low-temperature oxygenation of copper(I) complexes of N,N,N ‘,N ‘-tetraethylpropane-1,3-diamine yields solutions containing both μ-η2:η2-peroxodicopper(II) (P)…”
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Determination by X-ray Absorption Spectroscopy of the Fe−Fe Separation in the Oxidized Form of the Hydroxylase of Methane Monooxygenase Alone and in the Presence of MMOD by Jackson Rudd, Deanne, Sazinsky, Matthew H, Merkx, Maarten, Lippard, Stephen J, Hedman, Britt, Hodgson, Keith O

“…The diiron active site in the hydroxylase of Methylococcus capsulatus (Bath) methane monooxygenase (MMOH) has been studied in the oxidized form by X-ray…”
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Industrial Perspective on the Benefits Realized From the FDA’s Model‐Informed Drug Development Paired Meeting Pilot Program by Galluppi, Gerald R., Brar, Satjit, Caro, Luzelena, Chen, Yuan, Frey, Nicolas, Grimm, Hans Peter, Rudd, Deanne Jackson, Li, Chi‐Chung, Magee, Mindy, Mukherjee, Arnab, Nagao, Lee, Purohit, Vivek S., Roy, Amit, Salem, Ahmed Hamed, Sinha, Vikram, Suleiman, Ahmed A., Taskar, Kunal S., Upreti, Vijay V., Weber, Benjamin, Cook, Jack

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Single oral doses of MK-8507, a novel non-nucleoside reverse transcriptase inhibitor, suppress HIV-1 RNA for a week by Schürmann, Dirk, Rudd, Deanne Jackson, Schaeffer, Andrea, De Lepeleire, Inge, Friedman, Evan J., Robberechts, Martine, Zhang, Saijuan, Liu, Yang, Kandala, Bhargava, Keicher, Christian, Däumer, Martin, Hofmann, Jörg, Grobler, Jay A., Stoch, S. Aubrey, Iwamoto, Marian, Ankrom, Wendy

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Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial by Schürmann, Dirk, Rudd, Deanne Jackson, Zhang, Saijuan, De Lepeleire, Inge, Robberechts, Martine, Friedman, Evan, Keicher, Christian, Hüser, Andreas, Hofmann, Jörg, Grobler, Jay A, Stoch, S Aubrey, Iwamoto, Marian, Matthews, Randolph P

“…Islatravir (also known as ISL and MK-8591) is a unique nucleoside reverse transcriptase translocation inhibitor in clinical development for treatment of people…”
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