Search Results - "Jackson, N.W."

The structural and functional diversification of the Toxicofera reptile venom system by Fry, Bryan G., Casewell, Nicholas R., Wüster, Wolfgang, Vidal, Nicolas, Young, Bruce, Jackson, Timothy N.W.

“…The evolutionary origin and diversification of the reptilian venom system is described. The resolution of higher-order molecular phylogenetics has clearly…”
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Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance by Calvete, Juan J., Lomonte, Bruno, Saviola, Anthony J., Bonilla, Fabián, Sasa, Mahmood, Williams, David J., Undheim, Eivind A.B., Sunagar, Kartik, Jackson, Timothy N.W.

“…Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human lives annually worldwide. Snakebite occurs as the result of an…”
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Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains by Brust, Andreas, Sunagar, Kartik, Undheim, Eivind A.B., Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Jackson, Timothy N.W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan, Fry, Bryan G.

“…Snake venom metalloproteases (SVMP) are composed of five domains: signal peptide, propeptide, metalloprotease, disintegrin, and cysteine-rich. Secreted toxins…”
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How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting by Panagides, Nadya, Jackson, Timothy N W, Ikonomopoulou, Maria P, Arbuckle, Kevin, Pretzler, Rudolf, Yang, Daryl C, Ali, Syed A, Koludarov, Ivan, Dobson, James, Sanker, Brittany, Asselin, Angelique, Santana, Renan C, Hendrikx, Iwan, van der Ploeg, Harold, Tai-A-Pin, Jeremie, van den Bergh, Romilly, Kerkkamp, Harald M I, Vonk, Freek J, Naude, Arno, Strydom, Morné A, Jacobsz, Louis, Dunstan, Nathan, Jaeger, Marc, Hodgson, Wayne C, Miles, John, Fry, Bryan G

“…The cytotoxicity of the venom of 25 species of Old World elapid snake was tested and compared with the morphological and behavioural adaptations of hooding and…”
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Venom proteomic characterization and relative antivenom neutralization of two medically important Pakistani elapid snakes (Bungarus sindanus and Naja naja) by Ali, Syed A., Yang, Daryl C., Jackson, Timothy N.W., Undheim, Eivind A.B., Koludarov, Ivan, Wood, Kelly, Jones, Alun, Hodgson, Wayne C., McCarthy, Sean, Ruder, Tim, Fry, Bryan G.

“…Intra- and interspecific variation in venom composition has been shown to have a major effect upon the efficacy of antivenoms. Due to the absence of…”
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Dracula's children: Molecular evolution of vampire bat venom by Low, Dolyce H.W., Sunagar, Kartik, Undheim, Eivind A.B., Ali, Syed A., Alagon, Alejandro C., Ruder, Tim, Jackson, Timothy N.W., Pineda Gonzalez, Sandy, King, Glenn F., Jones, Alun, Antunes, Agostinho, Fry, Bryan G.

“…While vampire bat oral secretions have been the subject of intense research, efforts have concentrated only on two components: DSPA (Desmodus rotundus salivary…”
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Proteomic comparison of Hypnale hypnale (Hump-Nosed Pit-Viper) and Calloselasma rhodostoma (Malayan Pit-Viper) venoms by Ali, Syed A., Baumann, Kate, Jackson, Timothy N.W., Wood, Kelly, Mason, Steven, Undheim, Eivind A.B., Nouwens, Amanda, Koludarov, Ivan, Hendrikx, Iwan, Jones, Alun, Fry, Bryan Grieg

“…Treatment of Hypnale hypnale bites with commercial antivenoms, even those raised against its sister taxon Calloselasma rhodostoma, has never been clinically…”
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Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms by Ruder, Tim, Ali, Syed Abid, Ormerod, Kiel, Brust, Andreas, Roymanchadi, Mary-Louise, Ventura, Sabatino, Undheim, Eivind A.B., Jackson, Timothy N.W., Mercier, A. Joffre, King, Glenn F., Alewood, Paul F., Fry, Bryan G.

“…•Octopus venoms contain tachykinin peptides.•These peptides are more similar to vertebrate non-venom types than invertebrate.•These peptides are active on both…”
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Presumed congenital Gerbode defect in an American Domestic Shorthair cat by Tanner, M.C., Jackson, N.W., Thomason, J.D.

“…A five-month-old, intact female Domestic Shorthair cat presented to the Kansas State Veterinary Health Center for evaluation of a murmur and exercise…”
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Causes and Consequences of Snake Venom Variation by Casewell, Nicholas R., Jackson, Timothy N.W., Laustsen, Andreas H., Sunagar, Kartik

“…Snake venoms are mixtures of toxins that vary extensively between and within snake species. This variability has serious consequences for the management of the…”
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On the chemical ecology and evolvability of brown snakes (genus Pseudonaja) by Jackson, Timothy N.W., Thiel, Jory, Arnold, Georgie, Modahl, Cassandra

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Molecular mechanisms underlying the N-methyl-d-aspartate receptor antagonists: Highlighting their potential for transdiagnostic therapeutics by Driver, Christina, Jackson, Timothy N.W., Lagopoulos, Jim, Hermens, Daniel F.

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How the Toxin got its Toxicity by Jackson, Timothy N W, Koludarov, Ivan

“…Venom systems are functional and ecological traits, typically used by one organism to subdue or deter another. A predominant subset of their constituent…”
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Combination eravacycline therapy for ventilator‐associated pneumonia due to carbapenem‐resistant Acinetobacter baumannii in patients with COVID‐19: A case series by Jackson, Melissa N. W., Wei, Wenjing, Mang, Norman S., Prokesch, Bonnie C., Ortwine, Jessica K.

“…Background Carbapenem‐resistant Acinetobacter baumannii (CRAB) pneumonia is associated with poor clinical outcomes and increased mortality. Clinical data…”
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Domain loss enabled evolution of novel functions in the snake three-finger toxin gene superfamily by Koludarov, Ivan, Senoner, Tobias, Jackson, Timothy N. W., Dashevsky, Daniel, Heinzinger, Michael, Aird, Steven D., Rost, Burkhard

“…Three-finger toxins ( 3FTXs ) are a functionally diverse family of toxins, apparently unique to venoms of caenophidian snakes. Although the ancestral function…”
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Catch a tiger snake by its tail: Differential toxicity, co-factor dependence and antivenom efficacy in a procoagulant clade of Australian venomous snakes by Lister, Callum, Arbuckle, Kevin, Jackson, Timothy N.W., Debono, Jordan, Zdenek, Christina N., Dashevsky, Daniel, Dunstan, Nathan, Allen, Luke, Hay, Chris, Bush, Brian, Gillett, Amber, Fry, Bryan G.

“…A paradigm of venom research is adaptive evolution of toxins as part of a predator-prey chemical arms race. This study examined differential co-factor…”
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Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja) by Cipriani, Vittoria, Debono, Jordan, Goldenberg, Jonathan, Jackson, Timothy N.W., Arbuckle, Kevin, Dobson, James, Koludarov, Ivan, Li, Bin, Hay, Chris, Dunstan, Nathan, Allen, Luke, Hendrikx, Iwan, Kwok, Hang Fai, Fry, Bryan G.

“…Venom is a key evolutionary trait, as evidenced by its widespread convergent evolution across the animal kingdom. In an escalating prey-predator arms race,…”
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Snakebite envenoming: A systematic review and meta-analysis of global morbidity and mortality by Afroz, Afsana, Siddiquea, Bodrun Naher, Chowdhury, Hasina Akhter, Jackson, Timothy Nw, Watt, Andrew D

“…Snakebite envenoming represents a significant and often neglected public health challenge, particularly in rural communities across tropical and subtropical…”
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Contextual Constraints: Dynamic Evolution of Snake Venom Phospholipase A2 by Suranse, Vivek, Jackson, Timothy N. W., Sunagar, Kartik

“…Venom is a dynamic trait that has contributed to the success of numerous organismal lineages. Predominantly composed of proteins, these complex cocktails are…”
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Distinct regulatory networks control toxin gene expression in elapid and viperid snakes by Modahl, Cassandra M, Han, Summer Xia, van Thiel, Jory, Vaz, Candida, Dunstan, Nathan L, Frietze, Seth, Jackson, Timothy N W, Mackessy, Stephen P, Kini, R Manjunatha

“…Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common…”
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