Search Results - "Jackson, Michael W."

Affinity purification of serum-derived anti-IA-2 autoantibodies in type 1 diabetes using a novel MBP-IA-2 fusion protein by Mendis, Thilini, Filipova, Barbora, Wang, Jing Jing, Pietropaolo, Massimo, Jackson, Michael W.

“…Autoantibodies targeting epitopes contained within the intracellular domain (IC) of the protein phosphatase-like islet antigen 2 (IA-2) are a common marker of…”
Get full text

The ATP‐dependent ClpXP and Lon proteases regulate expression of the Yersinia pestis type III secretion system via regulated proteolysis of YmoA, a small histone‐like protein by Jackson, Michael W., Silva‐Herzog, Eugenia, Plano, Gregory V.

“…Summary The Yersinia pestis plasmid pCD1‐encoded type III secretion system (T3SS) is essential for the pathogenicity of Y. pestis in mammalian hosts…”
Get full text

The Yersinia pestis type III secretion needle plays a role in the regulation of Yop secretion by Torruellas, Julie, Jackson, Michael W., Pennock, Jeffry W., Plano, Gregory V.

“…Summary Activation of bacterial virulence‐associated type III secretion systems (T3SSs) requires direct contact between a bacterium and a eukaryotic cell. In…”
Get full text

Measurement of Effector Protein Injection by Type III and Type IV Secretion Systems by Using a 13-Residue Phosphorylatable Glycogen Synthase Kinase Tag by Torruellas Garcia, Julie, Ferracci, Franco, Jackson, Michael W, Joseph, Sabrina S, Pattis, Isabelle, Plano, Lisa R.W, Fischer, Wolfgang, Plano, Gregory V

“…Numerous bacterial pathogens use type III secretion systems (T3SSs) or T4SSs to inject or translocate virulence proteins into eukaryotic cells. Several…”
Get full text

B cell apotopes of the 60-kDa Ro/SSA and La/SSB autoantigens by Reed, Joanne H, Jackson, Michael W, Gordon, Tom P

“…Abstract Apoptosis has been proposed to influence the initiation and diversification of autoimmunity to the Ro (SSA)/La (SSB) ribonucleoprotein (RNP) particle…”
Get full text

Disruption of intestinal motility by a calcium channel-stimulating autoantibody in type 1 diabetes by Jackson, Michael W., Gordon, Tom P., Waterman, Sally A.

“…Background & Aims : Autonomic neuropathy, including gastrointestinal dysfunction, is a common complication of type 1 diabetes; however, its cause is uncertain…”
Get full text

250-LB: Affinity Purification and Identification of Unique, Shared, Anti-IA-2 B-Cell Clonotypes: A Proteomic Approach to Understanding Pathophysiological Mechanisms Underpinning Humoral Autoimmunity in Type 1 Diabetes by MENDIS, THILINI, WANG, JING JING, PIETROPAOLO, MASSIMO, JACKSON, MICHAEL W.

“…Immune destruction of beta (β) cells is a feature of type 1 diabetes (T1D), yet the pathophysiological role of autoantibodies (Abs) is poorly understood…”
Get full text

Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome by Park, Kyungpyo, Haberberger, Rainer V., Gordon, Tom P., Jackson, Michael W.

“…Objective In primary Sjögren's syndrome (SS), impairment of the gastrointestinal (GI) tract is common, and includes reduced esophageal motor function, delayed…”
Get full text

Calcium-Regulated Type III Secretion of Yop Proteins by an Escherichia coli hha Mutant Carrying a Yersinia pestis pCD1 Virulence Plasmid by BARTRA, Sara Schesser, JACKSON, Michael W, ROSS, Julia A, PLANO, Gregory V

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

A cell-based assay for the detection of pathogenic anti-voltage-gated calcium channel autoantibodies in immunoglobulin G from patients with type 1 diabetes by Alshehri, Ahmed M., Mendis, Thilini, Jackson, Michael W.

“…Recent studies have postulated the presence of functional autoantibodies (Abs) against L-type voltage gated calcium channels (VGCCs) in the serum of patients…”
Get full text

The inhibitory effects of antimuscarinic autoantibodies in the sera of primary Sjogren syndrome patients on the gastrointestinal motility by Park, Kyungpyo, Park, Sowon, Jackson, Michael W.

“…•There are antimuscarinic autoantibodies in primary Sjogren syndrome patients’ sera.•SS autoantibodies inhibit muscarinic receptor function in mouse colon and…”
Get full text

Neutralization of Muscarinic Receptor Autoantibodies by Intravenous Immunoglobulin in Sjögren Syndrome by Smith, Anthony J., Jackson, Michael W., Wang, Fang, Cavill, Dana, Rischmueller, Maureen, Gordon, Tom P.

“…Autoantibodies that inhibit M3 muscarinic receptor (M3R)-mediated neurotransmission and cause bladder and bowel dysfunction have been reported in patients with…”
Get full text

A novel cell-based assay for inhibitory anti-muscarinic type 3 receptor antibodies in primary Sjögren’s syndrome by Bastian, Isabell, Gordon, Tom P., Jackson, Michael W.

“…Inhibitory autoantibodies acting at the muscarinic acetylcholine receptor type 3 (M3R) are postulated to mediate autonomic dysfunction, including decreased…”
Get full text

Secreted autoantibody repertoires in Sjögren's syndrome and systemic lupus erythematosus: A proteomic approach by Al Kindi, Mahmood A, Colella, Alex D, Chataway, Tim K, Jackson, Michael W, Wang, Jing J, Gordon, Tom P

“…Abstract The structures of epitopes bound by autoantibodies against RNA–protein complexes have been well-defined over several decades, but little is known of…”
Get full text

IgV peptide mapping of native Ro60 autoantibody proteomes in primary Sjögren's syndrome reveals molecular markers of Ro/La diversification by Wang, Jing J, Al Kindi, Mahmood A, Colella, Alex D, Dykes, Lukah, Jackson, Michael W, Chataway, Tim K, Reed, Joanne H, Gordon, Tom P

“…Abstract We have used high-resolution mass spectrometry to sequence precipitating anti -Ro60 proteomes from sera of patients with primary Sjögren's syndrome…”
Get full text

Molecular signature of a public clonotypic autoantibody in primary Sjögren's syndrome: A “forbidden” clone in systemic autoimmunity by Lindop, Rhianna, Arentz, Georgia, Chataway, Tim K., Thurgood, Lauren A., Jackson, Michael W., Reed, Joanne H., McCluskey, James, Gordon, Tom P.

“…Objective This study was undertaken to determine the molecular characteristics of clonotypic autoantibodies in the sera of patients with primary Sjögren's…”
Get full text

YscB of Yersinia pestis Functions as a Specific Chaperone for YopN by Jackson, M W, Day, J B, Plano, G V

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Pathogenicity and proteomic signatures of autoantibodies to Ro and La by Lindop, Rhianna, Arentz, Georgia, Thurgood, Lauren A, Reed, Joanne H, Jackson, Michael W, Gordon, Tom P

“…Ro/SSA and La/SSB comprise a linked set of autoantigens that are clinically important members of the extractable nuclear antigen family and key translational…”
Get full text

Long-term Ro60 humoral autoimmunity in primary Sjögren's syndrome is maintained by rapid clonal turnover by Lindop, Rhianna, Arentz, Georgia, Bastian, Isabell, Whyte, Andrew F, Thurgood, Lauren A, Chataway, Tim K, Jackson, Michael W, Gordon, Tom P

“…Abstract Long-term humoral autoimmunity to RNA–protein autoantigens is considered a hallmark of systemic autoimmune diseases. We use high resolution Orbitrap…”
Get full text

Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides by Al Kindi, Mahmood A, Chataway, Tim K, Gilada, George A, Jackson, Michael W, Goldblatt, Fiona M, Walker, Jenny G, Colella, Alex D, Gordon, Tom P

“…Abstract Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human…”
Get full text