Search Results - "Jackson, Margaret V"

Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes by BREEN, Danna M, RASMUSSEN, Brittany A, COTE, Clémence D, MARGARET JACKSON, V, LAM, Tony K. T

“…The small intestine is traditionally viewed as an organ that mediates nutrient digestion and absorption. This view has recently been revised owing to the…”
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Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass by Lumsden, Amanda L, Martin, Alyce M, Sun, Emily W, Schober, Gudrun, Isaacs, Nicole J, Pezos, Nektaria, Wattchow, David A, de Fontgalland, Dayan, Rabbitt, Philippa, Hollington, Paul, Sposato, Luigi, Due, Steven L, Rayner, Christopher K, Nguyen, Nam Q, Liou, Alice P, Jackson, V Margaret, Young, Richard L, Keating, Damien J

“…Gut-derived serotonin (5-HT) is released from enterochromaffin (EC) cells in response to nutrient cues, and acts to slow gastric emptying and modulate gastric…”
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Characterization of [125I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta by Kuc, Rhoda E., Maguire, Janet J., Siew, Keith, Patel, Sheena, Derksen, David R., Margaret Jackson, V., O'Shaughnessey, Kevin M., Davenport, Anthony P.

“…Glucagon-like peptide 1 (GLP-1) is an insulin secretagogue, released in response to meal ingestion and efficiently lowers blood glucose in Type 2 diabetic…”
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Leptin potentiates the anti-obesity effects of rimonabant by Boustany-Kari, Carine M., Jackson, V. Margaret, Gibbons, Colleen P., Swick, Andrew G.

“…We hypothesized that a combination of low doses of rimonabant and leptin would markedly reduce body weight through the modulation of neuronal activity within…”
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Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues by Straub, Stephen V, Perez, Sylvie M, Tan, Beijing, Coughlan, Kimberly A, Trebino, Catherine E, Cosgrove, Patricia, Buxton, Joanne M, Kreeger, John M, Jackson, V Margaret

“…Genetic ablation of the voltage-gated potassium channel Kv1.3 improves insulin sensitivity and increases metabolic rate in mice. Inhibition of Kv1.3 in mouse…”
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Neuropeptide Modulation of a Lumbar Spinal Reflex: Potential Implications for Female Sexual Function by Wilson, Lesley A., Wayman, Chris P., Jackson, V. Margaret

“…Neuropeptides are known to modulate female receptivity. However, even though receptivity is a spinal reflex, the role of neuropeptides within the spinal cord…”
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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor by Griffith, David A., Edmonds, David J., Fortin, Jean-Philippe, Kalgutkar, Amit S., Kuzmiski, J. Brent, Loria, Paula M., Saxena, Aditi R., Bagley, Scott W., Buckeridge, Clare, Curto, John M., Derksen, David R., Dias, João M., Griffor, Matthew C., Han, Seungil, Jackson, V. Margaret, Landis, Margaret S., Lettiere, Daniel, Limberakis, Chris, Liu, Yuhang, Mathiowetz, Alan M., Patel, Jayesh C., Piotrowski, David W., Price, David A., Ruggeri, Roger B., Tess, David A.

“…Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require…”
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Pharmacokinetics and pharmacodynamics of PF‐05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects by Denney, William S., Sonnenberg, Gabriele E., Carvajal‐Gonzalez, Santos, Tuthill, Theresa, Jackson, V. Margaret

“…Aim To evaluate safety, tolerability and pharmacokinetics of oral PF‐05190457, an oral ghrelin receptor inverse agonist, in healthy adults. Methods Single…”
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Augmented capacity for peripheral serotonin release in human obesity by Young, Richard L., Lumsden, Amanda L., Martin, Alyce M., Schober, Gudrun, Pezos, Nektaria, Thazhath, Sony S., Isaacs, Nicole J., Cvijanovic, Nada, Sun, Emily W. L., Wu, Tongzhi, Rayner, Christopher K., Nguyen, Nam Q., Fontgalland, Dayan de, Rabbitt, Philippa, Hollington, Paul, Sposato, Luigi, Due, Steven L., Wattchow, David A., Liou, Alice P., Jackson, V. Margaret, Keating, Damien J.

“…Background/objectives Evidence from animal studies highlights an important role for serotonin (5-HT), derived from gut enterochromaffin (EC) cells, in…”
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Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca2+ transients in mouse vas deferens by Brain, Keith L., Jackson, V. Margaret, Trout, Stephen J., Cunnane, Thomas C.

“…A confocal Ca 2+ imaging technique has been used to detect ATP release from individual sympathetic varicosities on the same nerve terminal branch. Varicose…”
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A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans by Sun, Emily W., Iepsen, Eva W., Pezos, Nektaria, Lumsden, Amanda L., Martin, Alyce M., Schober, Gudrun, Isaacs, Nichole J., Rayner, Christopher K., Nguyen, Nam Q., de Fontgalland, Dayan, Rabbitt, Philippa, Hollington, Paul, Wattchow, David A., Hansen, Torben, Holm, Jens-Christian, Liou, Alice P., Jackson, V. Margaret, Torekov, Signe S., Young, Richard L., Keating, Damien J.

“…Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of energy homeostasis. Brain-penetrant MC4R agonists have failed, as concentrations required…”
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Latest approaches for the treatment of obesity by Jackson, V Margaret, Breen, Danna M, Fortin, Jean-Philippe, Liou, Alice, Kuzmiski, J Brent, Loomis, A Katrina, Rives, Marie-Laure, Shah, Bhavik, Carpino, Philip A

“…Obesity is a body weight disorder characterized by excess adiposity that increases the risk for developing co-morbidities such as type 2 diabetes. A large…”
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Investigational drugs in Phase II clinical trials for the treatment of obesity: implications for future development of novel therapies by Jackson, V Margaret, Price, David A, Carpino, Philip A

“…The discovery of new antiobesity agents has attracted considerable interest over the past decade, but many of the investigational agents that have advanced…”
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Characterization of action potential-evoked calcium transients in mouse postganglionic sympathetic axon bundles by Jackson, V. Margaret, Trout, Stephen J., Brain, Keith L., Cunnane, Tom C.

“…Action potential-evoked Ca 2+ transients in postganglionic sympathetic axon bundles in mouse vas deferens have been characterized using confocal microscopy and…”
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Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate by Bhattacharya, Samit K, Andrews, Kim, Beveridge, Ramsay, Cameron, Kimberly O, Chen, Chiliu, Dunn, Matthew, Fernando, Dilinie, Gao, Hua, Hepworth, David, Jackson, V. Margaret, Khot, Vishal, Kong, Jimmy, Kosa, Rachel E, Lapham, Kimberly, Loria, Paula M, Londregan, Allyn T, McClure, Kim F, Orr, Suvi T. M, Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A, Storer, Gregory, VanVolkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin

“…The identification of potent, highly selective orally bioavailable ghrelin receptor inverse agonists from a spiro-azetidino-piperidine series is described…”
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Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists by Orr, Suvi T. M, Beveridge, Ramsay, Bhattacharya, Samit K, Cameron, Kimberly O, Coffey, Steven, Fernando, Dilinie, Hepworth, David, Jackson, Margaret V, Khot, Vishal, Kosa, Rachel, Lapham, Kimberly, Loria, Paula M, McClure, Kim F, Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A, Storer, Gregory, von Volkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin

“…Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor…”
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Cholinergic innervation of the mouse isolated vas deferens by Cuprian, Alina M, Solanki, Pravesh, Jackson, Margaret V, Cunnane, Thomas C

“…Recently, a population of nerves has been described in the aganglionic mouse vas deferens, in which electrically evoked contractions were insensitive to high…”
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Bretylium or 6‐OHDA‐resistant, action potential‐evoked Ca2+ transients in varicosities of the mouse vas deferens by Jackson, V Margaret, Cunnane, Tom C

“…Action potential‐evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance…”
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Correlation of non-uniform protein expression with variation in transmitter release probability by Knight, David, Mann, Dwayne L., Jackson, V. Margaret, Trout, Stephen J., Cunnane, Tom C., Lavidis, Nickolas A.

“…The strength of synaptic transmission is highly variable between different synapses. The present study examined some factors that may contribute to this…”
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Regional variation in electrically‐evoked contractions of rabbit isolated pulmonary artery by Jackson, V Margaret, Trout, Stephen J, Cunnane, Tom C

“…Electrically‐evoked contractions in different regions of the rabbit isolated pulmonary artery have been investigated using stimulation parameters generally…”
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