Search Results - "Jackson, Joseph W"

There Is Always Another Way! Cytomegalovirus' Multifaceted Dissemination Schemes by Jackson, Joseph W, Sparer, Tim

“…Human cytomegalovirus (HCMV) is a β-herpes virus that is a significant pathogen within immune compromised populations. HCMV morbidity is induced through viral…”
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Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway by Chen, Tian, Jackson, Joseph W, Tams, Robert N, Davis, Sarah E, Sparer, Timothy E, Reynolds, Todd B

“…Candida albicans is among the most common causes of human fungal infections and is an important source of mortality. C. albicans is able to diminish its…”
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Preclinical evaluation of Tc-99m p5+14 peptide for SPECT detection of cardiac amyloidosis by Kennel, Stephen J, Jackson, Joseph W, Stuckey, Alan, Richey, Tina, Foster, James S, Wall, Jonathan S

“…Amyloid deposition is a cause of restrictive cardiomyopathy. Patients who present with cardiac disease can be evaluated for transthyretin (TTR)-associated…”
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Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction by Jones, Letitia D, Jackson, Joseph W, Maggirwar, Sanjay B

“…The number of HIV-1 positive individuals developing some form of HIV-associated neurocognitive disorder (HAND) is increasing. In these individuals, the…”
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Development and characterization of a prototypic pan-amyloid clearing agent – a novel murine peptide-immunoglobulin fusion by Foster, James S., Balachandran, Manasi, Hancock, Trevor J., Martin, Emily B., Macy, Sallie, Wooliver, Craig, Richey, Tina, Stuckey, Alan, Williams, Angela D., Jackson, Joseph W., Kennel, Stephen J., Wall, Jonathan S.

“…Introduction Systemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral…”
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Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal by Jackson, Joseph W., Foster, James S., Martin, Emily B., Macy, Sallie, Wooliver, Craig, Balachandran, Manasi, Richey, Tina, Heidel, R. Eric, Williams, Angela D., Kennel, Stephen J., Wall, Jonathan S.

“…Systemic amyloidosis refers to a group of protein misfolding disorders characterized by the extracellular deposition of amyloid fibrils in organs and tissues…”
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Sources of bias and limitations of thrombinography: inner filter effect and substrate depletion at the edge of failure algorithm by Jackson, Joseph W, Longstaff, Colin, Woodle, Samuel A, Chang, William C, Ovanesov, Mikhail V

“…Abstract Background Fluorogenic thrombin generation (TG) is a global hemostasis assay that provides an overall representation of hemostasis potential. However,…”
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Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function by Jackson, Joseph W., Rivera‐Marquez, Genesis M., Beebe, Kristin, Tran, Andy D., Trepel, Jane B., Gestwicki, Jason E., Blagg, Brian S. J., Ohkubo, Shuichi, Neckers, Leonard M.

“…Background Platelets play a pivotal role in hemostasis, wound healing, and inflammation, and are thus implicated in a variety of diseases, including cancer…”
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Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection by Weber, Emily A, Singh, Meera V, Singh, Vir B, Jackson, Joseph W, Ture, Sara K, Suwunnakorn, Sumanun, Morrell, Craig N, Maggirwar, Sanjay B

“…Background Microvesicles are cell membrane-derived vesicles that have been shown to augment inflammation. Specifically, monocyte-derived microvesicles (MDMVs),…”
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Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis by Collier, J. Jason, Batdorf, Heidi M., Martin, Thomas M., Rohli, Kristen E., Burk, David H., Lu, Danhong, Cooley, Chris R., Karlstad, Michael D., Jackson, Joseph W., Sparer, Tim E., Zhang, Jingying, Mynatt, Randall L., Burke, Susan J.

“…The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are…”
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Effect of pH on thrombin activity measured by calibrated automated thrombinography by Jackson, Joseph W., Surov, Stepan S., Liang, Yideng, Parunov, Leonid A., Ovanesov, Mikhail V.

“…[...]the internal CAT thrombin calibrator (thrombin‐α2 macroglobulin complex) may be helpful in correcting the effects of pH. Unfortunately, CAT assay reagents…”
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Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment by Jackson, Joseph W., Hall, Bonnie L., Marzulli, Marco, Shah, Vrusha K., Bailey, Lisa, Chiocca, E. Antonio, Goins, William F., Kohanbash, Gary, Cohen, Justus B., Glorioso, Joseph C.

“…Oncolytic herpes simplex viruses (oHSVs) have demonstrated efficient lytic replication in human glioblastoma tumors using immunodeficient mouse models, but…”
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Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis by Jackson, Joseph W, Singh, Meera V, Singh, Vir B, Jones, Letitia D, Davidson, Gregory A, Ture, Sara, Morrell, Craig N, Schifitto, Giovanni, Maggirwar, Sanjay B

“…Platelets play an essential role in hemostasis and wound healing by facilitating thrombus formation at sites of injury. Platelets also mediate inflammation and…”
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Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples by Chang, William C., Jackson, Joseph W., Machlus, Kellie R., Wolberg, Alisa S., Ovanesov, Mikhail V.

“…The thrombin generation (TG) test is a global hemostasis assay sensitive to procoagulant conditions. However, some TG assays may underestimate elevated TG when…”
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Detecting factor XIa in immune globulin products: Commutability of international reference materials for traditional and global hemostasis assays by Liang, Yideng, Jackson, Joseph W., Woodle, Samuel A., Surov, Stepan S., Parunov, Leonid A., Scott, Dorothy E., Weinstein, Mark, Lee, Timothy K., Ovanesov, Mikhail V.

“…Activated coagulation factor XIa (FXIa) is an impurity and primary source of procoagulant activity in thrombosis‐implicated immune globulin (IG) products…”
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Considerations on activity assay discrepancies in factor VIII and factor IX products by Ovanesov, Mikhail V., Jackson, Joseph W., Golding, Basil, Lee, Timothy K.

“…New modified coagulation factor VIII (FVIII) and factor IX (FIX) products have been designed to improve the treatment of individuals with hemophilia A and B by…”
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Exposure of Candida albicans [beta] -glucan is promoted by activation of the Cek1 pathway by Chen, Tian, Jackson, Joseph W, Tams, Robert N, Davis, Sarah E, Sparer, Timothy E, Reynolds, Todd B

“…Candida albicans is among the most common causes of human fungal infections and is an important source of mortality. C. albicans is able to diminish its…”
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Induction of neutrophil extracellular traps by Campylobacter jejuni by Callahan, Sean, Doster, Ryan S., Jackson, Joseph W., Kelley, Brittni R., Gaddy, Jennifer A., Johnson, Jeremiah G.

“…Campylobacter jejuni is the leading cause of bacterial‐derived gastroenteritis worldwide and can lead to several post‐infectious inflammatory disorders…”
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Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation by Singh, Meera V, Davidson, Donna C, Jackson, Joseph W, Singh, Vir B, Silva, Jharon, Ramirez, Servio H, Maggirwar, Sanjay B

“…HIV-1-associated neuroinflammation persists even with effective combined antiretroviral therapy, and it is associated with the presence of activated…”
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Human platelet concentrates treated with microbicidal 405 nm light retain hemostasis activity by Jackson, Joseph W., Kaldhone, Pravin R., Parunov, Leonid A., Stewart, Caitlin F., Anderson, John G., MacGregor, Scott J., Maclean, Michelle, Atreya, Chintamani D.

“…Chemical and UV light-based pathogen reduction technologies are currently in use for human platelet concentrates (PCs) to enhance safety from…”
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