Search Results - "Jackson, Jennifer B."

Simple, multiplexed, PCR-based barcoding of DNA enables sensitive mutation detection in liquid biopsies using sequencing by Ståhlberg, Anders, Krzyzanowski, Paul M, Jackson, Jennifer B, Egyud, Matthew, Stein, Lincoln, Godfrey, Tony E

“…Detection of cell-free DNA in liquid biopsies offers great potential for use in non-invasive prenatal testing and as a cancer biomarker. Fetal and tumor DNA…”
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Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner by Jackson, Jennifer B, Pallas, David C

“…Abstract Heterotrimeric protein phosphatase 2A (PP2A) consists of catalytic C (PP2Ac), structural A, and regulatory B-type subunits, and its dysfunction has…”
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Real-world comprehensive genomic and immune profiling reveals distinct age- and sex-based genomic and immune landscapes in tumors of patients with non-small cell lung cancer by Wallen, Zachary D, Ko, Heidi, Nesline, Mary K, Hastings, Stephanie B, Strickland, Kyle C, Previs, Rebecca A, Zhang, Shengle, Pabla, Sarabjot, Conroy, Jeffrey, Jackson, Jennifer B, Saini, Kamal S, Jensen, Taylor J, Eisenberg, Marcia, Caveney, Brian, Sathyan, Pratheesh, Severson, Eric A, Ramkissoon, Shakti H

“…Younger patients with non-small cell lung cancer (NSCLC) (<50 years) represent a significant patient population with distinct clinicopathological features and…”
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Multiplex Preamplification of Serum DNA to Facilitate Reliable Detection of Extremely Rare Cancer Mutations in Circulating DNA by Digital PCR by Jackson, Jennifer B, Choi, Daniel S, Luketich, James D, Pennathur, Arjun, Ståhlberg, Anders, Godfrey, Tony E

“…Tumor-specific mutations can be identified in circulating, cell-free DNA in plasma or serum and may serve as a clinically relevant alternative to biopsy…”
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Comprehensive NGS profiling to enable detection of ALK gene rearrangements and MET amplifications in non-small cell lung cancer by Clavé, Sergi, Jackson, Jennifer B, Salido, Marta, Kames, Jacob, Gerding, Kelly M R, Verner, Ellen L, Kong, Eric F, Weingartner, Elizabeth, Gibert, Joan, Hardy-Werbin, Max, Rocha, Pedro, Riera, Xènia, Torres, Erica, Hernandez, James, Cerqueira, Gustavo, Nichol, Donna, Simmons, John, Taus, Álvaro, Pijuan, Lara, Bellosillo, Beatriz, Arriola, Edurne

“…Next-generation sequencing (NGS) is currently widely used for biomarker studies and molecular profiling to identify concurrent alterations that can lead to the…”
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Non-equivalence of nuclear import among nuclei in multinucleated skeletal muscle cells by Cutler, Alicia A, Jackson, Jennifer B, Corbett, Anita H, Pavlath, Grace K

“…Skeletal muscle is primarily composed of large myofibers containing thousands of post-mitotic nuclei distributed throughout a common cytoplasm. Protein…”
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Designing and 3D Printing an Improved Method of Measuring Contact Angle in the Middle School Classroom by Crowe, Charles D, Hendrickson-Stives, Albanie K, Kuhn, Stephanie L, Jackson, Jennifer B, Keating, Christine D

“…The interaction between water and surfaces is observed in our daily lives and is used in laboratories to study materials properties, such as interfacial…”
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Validation of the Labcorp Plasma Focus Test to Facilitate Precision Oncology Through Cell-Free DNA Genomic Profiling of Solid Tumors by Verner, Ellen L., Jackson, Jennifer B., Severson, Eric, Valkenburg, Kenneth C., Greer, Amy E., Riley, David R., Sausen, Mark, Maddox, Cynthia, McGregor, Paul M., Karandikar, Aanavi, Hastings, Stephanie B., Previs, Rebecca A., Reddy, Venkataprasanth P., Jensen, Taylor J., Ramkissoon, Shakti H.

“…Genomic profiling is critical for precision oncology to guide treatment decisions. Liquid biopsy testing is a complementary approach to tissue testing,…”
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Next-Generation Sequencing Concordance Analysis of Comprehensive Solid Tumor Profiling between a Centralized Specialty Laboratory and the Decentralized Personal Genome Diagnostics elio Tissue Complete Kitted Solution by Deak, Kristen L., Jackson, Jennifer B., Valkenburg, Kenneth C., Keefer, Laurel A., Robinson Gerding, Kelly M., Angiuoli, Samuel V., Datto, Michael B., McCall, Shannon J.

“…Genomic tumor profiling by next-generation sequencing (NGS) allows for large-scale tumor testing to inform targeted cancer therapies and immunotherapies, and…”
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1499 Molecular and immune profiling of lobular-enriched versus non-lobular invasive breast cancers by Strickland, Kyle C, Pabla, Sarabjot, Ko, Heidi, Previs, Rebecca A, Wallen, Zachary D, Nesline, Mary K, Zhang, Shengle, Conroy, Jeffrey M, Jackson, Jennifer B, Saini, Kamal S, Jensen, Taylor J, Caveney, Brian, Eisenberg, Marcia, Reddy, Prasanth, Severson, Eric A, Ramkissoon, Shakti

“…BackgroundInvasive lobular carcinoma (ILC) is a morphologically distinct endocrine-sensitive sub-type of invasive breast cancer. Invasive ductal carcinoma has…”
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183 Comprehensive genomic and immune profiling (CGIP) reveals a distinct genomic and immune gene expression profile for younger patients with non-small cell lung cancer (NSCLC) by Wallen, Zachary D, Ko, Heidi, Nesline, Mary K, Hastings, Stephanie B, Strickland, Kyle C, Previs, Rebecca A, Zhang, Shengle, Pabla, Sarabjot, Conroy, Jeffrey M, Jackson, Jennifer B, Saini, Kamal S, Jensen, Taylor J, Caveney, Brian, Sathyan, Pratheesh, Reddy, Prasanth, Severson, Eric A, Ramkissoon, Shakti

“…BackgroundNSCLC tumors in younger patients may be enriched for targetable genomic alterations, yet these patients have lower rates of insurance coverage for…”
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Analytical validation of the Labcorp Plasma Complete test to enable precision oncology through solid tumor liquid biopsy comprehensive genomic profiling by Verner, Ellen, Valkenburg, Kenneth C., Maddox, Cynthia, Gerding, Kelly, Occean, James, White, James R, Morris, Laine, Jackson, Nesha, Dillon, Sonomi, Jackson, Jennifer B, Sausen, Mark, Severson, Eric A, Jensen, Taylor J., Eisenberg, Marcia, Caveney, Brian, Ramkissoon, Shakti H, Greer, Amy

“…3063 Background: To help guide treatment decisions and enable clinical trial matching for cancer patients, tumor genomic profiling is an essential precision…”
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Comparison of immune microenvironment between primary and metastatic breast tumors by Ko, Heidi Chwan, Pabla, Sarabjot, Nesline, Mary K, Gandhi, Shipra, Strickland, Kyle C, Previs, Rebecca A., Wallen, Zachary D, Zhang, Shengle, Conroy, Jeffrey M., Sausen, Mark, Jackson, Jennifer B, Saini, Kamal S., Wise, Scott, Jensen, Taylor J., Reddy, Venkataprasanth P., Severson, Eric A, Ramkissoon, Shakti

“…1030 Background: Immune evasion is one of the mechanisms by which cancer cells gain the ability to metastasize from the primary tumor to distant sites. In…”
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The impact of single gene testing (SGT) on subsequent comprehensive genomic profiling (CGP) success in community oncology practice for advanced non-small cell lung cancer (NSCLC): Results from a prospective observational reference laboratory testing program by Nesline, Mary K, DePietro, Paul, Cooper, Maureen, Zhang, Shengle, Howarth, Sarah, Wallen, Zachary D, Biorn, Michael D, Strickland, Kyle C, Previs, Rebecca A., Ko, Heidi Chwan, Sausen, Mark, Jackson, Jennifer B, Saini, Kamal S., Wise, Scott, Jensen, Taylor J., Pabla, Sarabjot, Conroy, Jeffrey M., Reddy, Prasanth, Severson, Eric A, Ramkissoon, Shakti

“…6506 Background: CGP concurrently tests tumor tissue for guideline-recommended predictive biomarkers for optimal therapy selection and identification of…”
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Effect of homologous recombination deficient (HRD) breast cancers on a distinct immune marker phenotype by comprehensive genomic and immune profiling (CGIP) by Ko, Heidi Chwan, Pabla, Sarabjot, Nesline, Mary K, Strickland, Kyle C, Previs, Rebecca A., Wallen, Zachary D, Zhang, Shengle, Conroy, Jeffrey M., Sausen, Mark, Jackson, Jennifer B, Saini, Kamal S., Wise, Scott, Jensen, Taylor J., Reddy, Venkataprasanth P., Severson, Eric A, Ramkissoon, Shakti

“…1029 Background: Preclinical evidence suggests that breast cancer with features of genomic instability may upregulate the host antitumor immune response by…”
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Abstract 5020: Pre-analytical characterization of cell-free DNA to enable liquid biopsy for solid tumors by Summersgill, Robert J., Fox, Jesse M., Dickey, Jennifer S., Cox, Liam T., Palumbo, Cal D., Valkenburg, Kenneth C., Caveney, Brian J., Ramkissoon, Shakti, Jackson, Jennifer B.

“…Abstract Background: The integration of liquid biopsy in oncology has transformed clinical management of patients with cancer. Cell-free DNA (cfDNA) represents…”
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Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner1 by Jackson, Jennifer B, Pallas, David C

“…Heterotrimeric protein phosphatase 2A (PP2A) consists of catalytic C (PP2Ac), structural A, and regulatory B-type subunits, and its dysfunction has been linked…”
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Abstract 6443: Enhanced detection of ctDNA molecular response for immunotherapy treated non-small cell lung cancer through analyses of cell-free and matched white blood cell DNA by Jackson, Jennifer B., Rocha, Pedro, White, James R., Georgiadis, Andrew P., Verner, Ellen L., Greer, Amy, Mora, Rafael Bach, Pintó, Laura Masfarré, Navarro, Nil, Taus, Álvaro, Paricio, Beatriz Bellosillo, Clavé, Sergi, Sausen, Mark T., Arriola, Edurne

“…Abstract Introduction: Immune checkpoint inhibitors (ICIs) have greatly improved clinical outcomes for patients with non-small cell lung cancer (NSCLC),…”
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Abstract B028: Analytical validation of tumor-informed whole genome sequencing analyses for detection of molecular residual disease in solid tumors by Victor, Kaitlin, Georgiadis, Andrew, Verner, Ellen, Simmons, Antoine, Riley, David, White, James R, Greco, Christopher, Cox, Liam, Fox, Jesse, Jackson, Jennifer B, Severson, Eric A, Caveney, Brian J, Eisenberg, Marcia, Jensen, Taylor J, Ramkissoon, Shakti, Angiuoli, Samuel V, Greer, Amy, Valkenburg, Kenneth, Sausen, Mark

“…Abstract Introduction: Across all patients diagnosed with solid tumors, approximately two-thirds initially present with locoregional disease and are…”
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Investigating the Tumor Suppressive Role of PP2Ac Methylation: Implications for SV40 and Polyomavirus-mediated Transformation by Jackson, Jennifer B

“…PP2A regulates growth and survival pathways and its dysfunction has been linked to cancer. The heterotrimeric PP2A holoenzyme consists of catalytic C (PP2Ac),…”
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