Search Results - "Jackson, J L"

Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth by Roskin, Krishna M., Jackson, Katherine J. L., Lee, Ji-Yeun, Hoh, Ramona A., Joshi, Shilpa A., Hwang, Kwan-Ki, Bonsignori, Mattia, Pedroza-Pacheco, Isabela, Liao, Hua-Xin, Moody, M. Anthony, Fire, Andrew Z., Borrow, Persephone, Haynes, Barton F., Boyd, Scott D.

“…A goal of HIV vaccine development is to elicit antibodies with neutralizing breadth. Broadly neutralizing antibodies (bNAbs) to HIV often have unusual…”
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Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire by Rodriguez, Oscar L., Safonova, Yana, Silver, Catherine A., Shields, Kaitlyn, Gibson, William S., Kos, Justin T., Tieri, David, Ke, Hanzhong, Jackson, Katherine J. L., Boyd, Scott D., Smith, Melissa L., Marasco, Wayne A., Watson, Corey T.

“…Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants…”
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The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains by Collins, Andrew M., Wang, Yan, Roskin, Krishna M., Marquis, Christopher P., Jackson, Katherine J. L.

“…The human and mouse antibody repertoires are formed by identical processes, but like all small animals, mice only have sufficient lymphocytes to express a…”
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Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection by Phetsouphanh, Chansavath, Jacka, Brendan, Ballouz, Sara, Jackson, Katherine J. L., Wilson, Daniel B., Manandhar, Bikash, Klemm, Vera, Tan, Hyon-Xhi, Wheatley, Adam, Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Starr, Mitchell, Cunningham, Phillip, Turville, Stuart G., Kent, Stephen J., Byrne, Anthony, Brew, Bruce J., Darley, David R., Dore, Gregory J., Kelleher, Anthony D., Matthews, Gail V.

“…This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID…”
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Comment on "A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data" by Watson, Corey T, Matsen, 4th, Frederick A, Jackson, Katherine J L, Bashir, Ali, Smith, Melissa Laird, Glanville, Jacob, Breden, Felix, Kleinstein, Steven H, Collins, Andrew M, Busse, Christian E

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Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination by Ellebedy, Ali H, Jackson, Katherine J L, Kissick, Haydn T, Nakaya, Helder I, Davis, Carl W, Roskin, Krishna M, McElroy, Anita K, Oshansky, Christine M, Elbein, Rivka, Thomas, Shine, Lyon, George M, Spiropoulou, Christina F, Mehta, Aneesh K, Thomas, Paul G, Boyd, Scott D, Ahmed, Rafi

“…Immunologic memory promotes faster and more-efficient responses after re-exposure to pathogens. Ahmed and colleagues characterize a subset of human B cells…”
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Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination by Davis, Carl W, Jackson, Katherine J L, McCausland, Megan M, Darce, Jaime, Chang, Cathy, Linderman, Susanne L, Chennareddy, Chakravarthy, Gerkin, Rebecca, Brown, Shantoria J, Wrammert, Jens, Mehta, Aneesh K, Cheung, Wan Cheung, Boyd, Scott D, Waller, Edmund K, Ahmed, Rafi

“…A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains…”
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Brief Report: Self-Reported Academic, Social, and Mental Health Experiences of Post-Secondary Students with Autism Spectrum Disorder by Jackson, Scott L. J., Hart, Logan, Brown, Jane Thierfeld, Volkmar, Fred R.

“…Increasing numbers of individuals with autism spectrum disorder (ASD) are enrolling in post-secondary academic institutions. However, research indicates that…”
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Tricyclic antidepressants and headaches: systematic review and meta-analysis by Jackson, Jeffrey L, Shimeall, William, Sessums, Laura, DeZee, Kent J, Becher, Dorothy, Diemer, Margretta, Berbano, Elizabeth, O’Malley, Patrick G

“…Objective To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches…”
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Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels by Jackson, Katherine J L, Wang, Yan, Collins, Andrew M

“…Somatic point mutations provide glimpses into B‐cell histories, and mutation numbers generally correlate with antibody affinity. We recently proposed a model…”
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Next-Generation Sequencing of Antibody Display Repertoires by Rouet, Romain, Jackson, Katherine J L, Langley, David B, Christ, Daniel

“…selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high…”
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Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans by Ellebedy, Ali H., Nachbagauer, Raffael, Jackson, Katherine J. L., Dai, Ya-Nan, Han, Julianna, Alsoussi, Wafaa B., Davis, Carl W., Stadlbauer, Daniel, Rouphael, Nadine, Chromikova, Veronika, McCausland, Megan, Chang, Cathy Y., Cortese, Mario, Bower, Mary, Chennareddy, Chakravarthy, Schmitz, Aaron J., Zarnitsyna, Veronika I., Lai, Lilin, Rajabhathor, Arvind, Kazemian, Cheyann, Antia, Rustom, Mulligan, Mark J., Ward, Andrew B., Fremont, Daved H., Boyd, Scott D., Pulendran, Bali, Krammer, Florian, Ahmed, Rafi

“…There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus…”
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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues by Yang, Fan, Nielsen, Sandra C A, Hoh, Ramona A, Röltgen, Katharina, Wirz, Oliver Fabian, Haraguchi, Emily, Jean, Grace H, Lee, Ji-Yeun, Pham, Tho D, Jackson, Katherine J L, Roskin, Krishna M, Liu, Yi, Nguyen, Khoa, Ohgami, Robert S, Osborne, Eleanor M, Nadeau, Kari C, Niemann, Claus U, Parsonnet, Julie, Boyd, Scott D

“…Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated…”
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A Temporal Model of Human IgE and IgG Antibody Function by Collins, Andrew M, Jackson, Katherine J L

“…The diversity of the human antibody repertoire that is generated by V(D)J gene rearrangement is extended by nine constant region genes that give antibodies…”
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Shaping of infant B cell receptor repertoires by environmental factors and infectious disease by Nielsen, Sandra C A, Roskin, Krishna M, Jackson, Katherine J L, Joshi, Shilpa A, Nejad, Parastu, Lee, Ji-Yeun, Wagar, Lisa E, Pham, Tho D, Hoh, Ramona A, Nguyen, Khoa D, Tsunemoto, Hannah Y, Patel, Sonal B, Tibshirani, Robert, Ley, Catherine, Davis, Mark M, Parsonnet, Julie, Boyd, Scott D

“…Antigenic exposures at epithelial sites in infancy and early childhood are thought to influence the maturation of humoral immunity and modulate the risk of…”
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Modeling human adaptive immune responses with tonsil organoids by Wagar, Lisa E., Salahudeen, Ameen, Constantz, Christian M., Wendel, Ben S., Lyons, Michael M., Mallajosyula, Vamsee, Jatt, Lauren P., Adamska, Julia Z., Blum, Lisa K., Gupta, Neha, Jackson, Katherine J. L., Yang, Fan, Röltgen, Katharina, Roskin, Krishna M., Blaine, Kelly M., Meister, Kara D., Ahmad, Iram N., Cortese, Mario, Dora, Emery G., Tucker, Sean N., Sperling, Anne I., Jain, Aarti, Davies, D. Huw, Felgner, Philip L., Hammer, Gregory B., Kim, Peter S., Robinson, William H., Boyd, Scott D., Kuo, Calvin J., Davis, Mark M.

“…Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In…”
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IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection by Wang, Yan, Jackson, Katherine J L, Davies, Janet, Chen, Zhiliang, Gaeta, Bruno A, Rimmer, Janet, Sewell, William A, Collins, Andrew M

“…Antigen selection of B cells within the germinal center reaction generally leads to the accumulation of replacement mutations in the…”
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Brief Report: A Specialized Fitness Program for Individuals with Autism Spectrum Disorder Benefits Physical, Behavioral, and Emotional Outcomes by Jackson, Scott L. J., Abel, Emily A., Reimer, Shara, McPartland, James C.

“…Individuals with autism spectrum disorder (ASD) engage in less physical activity than typically-developing peers. This can result in serious negative…”
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The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor by Jackson, Katherine J L, Kidd, Marie J, Wang, Yan, Collins, Andrew M

“…Both the B cell receptor (BCR) and the T cell receptor (TCR) repertoires are generated through essentially identical processes of V(D)J recombination,…”
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Brief Report: Exploratory Evaluation of Clinical Features Associated with Suicidal Ideation in Youth with Autism Spectrum Disorder by Ellison, Kimberly S., Jarzabek, Elzbieta, Jackson, Scott L. J., Naples, Adam, McPartland, James C.

“…There has been a heightened awareness of an increased risk of suicidality among individuals with autism spectrum disorder (ASD) due to high rates of suicidal…”
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