Search Results - "Jackson, Isabel L."

Psychological stress enhances tumor growth and diminishes radiation response in preclinical model of lung cancer by Zhang, Yi, Zanos, Panos, Jackson, Isabel L., Zhang, Xiuwu, Zhu, Xiongzhao, Gould, Todd, Vujaskovic, Zeljko

“…•Psychological stress-induced depression increased tumor growth and radioresistance.•Psychological stress activates epithelial-mesenchymal transition…”
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Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis by Sabirzhanov, Boris, Makarevich, Oleg, Barrett, James, Jackson, Isabel L, Faden, Alan I, Stoica, Bogdan A

“…Radiation-induced central nervous system toxicity is a significant risk factor for patients receiving cancer radiotherapy. Surprisingly, the mechanisms…”
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Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury by Jones, Jace W., Jackson, Isabel L., Vujaskovic, Zeljko, Kaytor, Michael D., Kane, Maureen A.

“…Purpose Biomarkers serve a number of purposes during drug development including defining the natural history of injury/disease, serving as a secondary endpoint…”
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A Systematic Review of Metabolomic and Lipidomic Candidates for Biomarkers in Radiation Injury by Vicente, Elisabeth, Vujaskovic, Zeljko, Jackson, Isabel L.

“…A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care and laboratory-based diagnostic and prognostic biomarkers to…”
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Irradiation-Induced Upregulation of miR-711 Inhibits DNA Repair and Promotes Neurodegeneration Pathways by Sabirzhanov, Boris, Makarevich, Oleg, Barrett, James P, Jackson, Isabel L, Glaser, Ethan P, Faden, Alan I, Stoica, Bogdan A

“…Radiotherapy for brain tumors induces neuronal DNA damage and may lead to neurodegeneration and cognitive deficits. We investigated the mechanisms of…”
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A Further Comparison of Pathologies after Thoracic Irradiation among Different Mouse Strains: Finding the Best Preclinical Model for Evaluating Therapies Directed Against Radiation-Induced Lung Damage by Jackson, Isabel L, Vujaskovic, Zeljko, Down, Julian D

“…The human lung is among the most sensitive and critical tissues of concern in localized and systemic radiation exposures, and it is a subject of active…”
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Revisiting Strain-Related Differences in Radiation Sensitivity of the Mouse Lung: Recognizing and Avoiding the Confounding Effects of Pleural Effusions by Jackson, Isabel L., Vujaskovic, Zeljko, Down, Julian D.

“…The mouse has been used extensively to model radiation injury to the lung, a major dose-limiting organ for radiotherapy. Substantial differences in the timing…”
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Oxidative Stress Mediates Radiation Lung Injury by Inducing Apoptosis by Zhang, Yu, Zhang, Xiuwu, M.D., Ph.D, Rabbani, Zahid N., M.D, Jackson, Isabel L., B.S, Vujaskovic, Zeljko, M.D., Ph.D

“…Purpose Apoptosis in irradiated normal lung tissue has been observed several weeks after radiation. However, the signaling pathway propagating cell death after…”
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Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction in Rats by Mahmood, Javed, Connors, Caroline Q., Alexander, Allen A., Pavlovic, Radmila, Samanta, Santanu, Soman, Sandrine, Matsui, Hotaka, Sopko, Nikolai A., Bivalacqua, Trinity J., Weinreich, Daniel, Ho, Cheng-Ying, Eley, John, Sawant, Amit, Jackson, Isabel L., Vujaskovic, Zeljko

“…Radiation-induced erectile-dysfunction (RiED) is one of the most common side effects of radiation therapy (RT) and significantly reduces the quality of life…”
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Temporal Onset of Hypoxia and Oxidative Stress After Pulmonary Irradiation by Fleckenstein, Katharina, M.D, Zgonjanin, Larisa, M.D, Chen, Liguang, M.D., Ph.D, Rabbani, Zahid, M.D, Jackson, Isabel L., B.S, Thrasher, Bradley, B.S.E, Kirkpatrick, John, M.D., Ph.D, Foster, W. Michael, Ph.D, Vujaskovic, Zeljko, M.D., Ph.D

“…Purpose: To investigate the temporal onset of hypoxia following irradiation, and to show how it relates to pulmonary vascular damage, macrophage accumulation,…”
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Ultraperformance convergence chromatography‐high resolution tandem mass spectrometry for lipid biomarker profiling and identification by Jones, Jace W., Carter, Claire L., Li, Fei, Yu, Jianshi, Pierzchalski, Keely, Jackson, Isabel L., Vujaskovic, Zeljko, Kane, Maureen A.

“…Lipids represent biologically ubiquitous and highly dynamic molecules in terms of abundance and structural diversity. Whereas the potential for lipids to…”
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Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease by Jackson, Isabel L, Baye, Fitsum, Goswami, Chirayu P, Katz, Barry P, Zodda, Andrew, Pavlovic, Radmila, Gurung, Ganga, Winans, Don, Vujaskovic, Zeljko

“…Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we…”
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Using Biological Markers to Predict Risk of Radiation Injury by Fleckenstein, Katharina, MD, Gauter-Fleckenstein, Benjamin, MD, Jackson, Isabel L., BS, Rabbani, Zahid, MD, Anscher, Mitchell, MD, Vujaskovic, Zeljko, MD, PhD

“…Recent advances in our understanding of the molecular events leading to the development of normal tissue complications after radiotherapy has led to an effort…”
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Role of Oxidative Stress in a Rat Model of Radiation-Induced Erectile Dysfunction by Kimura, Masaki, Rabbani, Zahid N., Zodda, Andrew R., Yan, Hui, Jackson, Isabel L., Polascik, Thomas J., Donatucci, Craig F., Moul, Judd W., Vujaskovic, Zeljko, Koontz, Bridget F.

“…Chronic oxidative stress is one of the major factors playing an important role in radiation-induced normal tissue injury. However, the role of oxidative stress…”
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ASTRO Journals’ Data Sharing Policy and Recommended Best Practices by Tegbaru, Dawit, BA, Braverman, Lisa, MA, Zietman, Anthony L., MD, FASTRO, Yom, Sue S., MD, PhD, MAS, Lee, W. Robert, MD, MS, MEd, Miller, Robert C., MD, MBA, FASTRO, Jackson, Isabel L., PhD, McNutt, Todd, PhD, Dekker, Andre, PhD

“…AbstractTransparency, openness, and reproducibility are important characteristics in scientific publishing. Although many researchers embrace these…”
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Best Practices for Authentication of Cell Lines to Ensure Data Reproducibility and Integrity by Vicente, Elisabeth, Lesniewski, Megan, Newman, Diana, Vujaskovic, Zeljko, Jackson, Isabel L

“…Cell line misidentification and contamination are major contributors to the reproducibility crisis in academic research. Authentication of cell lines provides…”
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BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high‐dose radiation exposure in the C57L/J murine model by Jackson, Isabel L, Zodda, Andrew, Gurung, Ganga, Pavlovic, Radmila, Kaytor, Michael D, Kuskowski, Michael A, Vujaskovic, Zeljko

“…Background and Purpose BIO 300 nanosuspension (Humanetics Corporation) is being developed as a medical countermeasure (MCM) for the mitigation of the delayed…”
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Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit by Poirier, Yannick, Prado, Charlotte, Prado, Karl, Draeger, Emily, Jackson, Isabel L, Vujaskovic, Zeljko

“…Well-controlled ionizing radiation injury animal models for testing medical countermeasure efficacy require robust radiation physics and dosimetry to ensure…”
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Thank you to those who Peer Reviewed in 2018 for Advances in Radiation Oncology by Miller, Robert C., MD, MBA, FASTRO, Deville, Curtiland, MD, Goyal, Sharad, MD, Hintenlang, Kathleen M., PhD, FAAPM, FACR, Hoppe, Bradford S., MD, MPH, Jackson, Isabel L., PhD, Kim, Sinae, PhD, Small, William, MD, FACRO, FACR, FASTRO, Tsai, Chiaojung Jillian, MD, PhD, Videtic, Gregory, MD, Yashar, Catheryn, MD, Knoll, Miriam A., MD, Tegbaru, Dawit, BA

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BIO 300, a Nanosuspension of Genistein, Mitigates Radiation-Induced Erectile Dysfunction and Sensitizes Human Prostate Cancer Xenografts to Radiation Therapy by Jackson, Isabel L., Pavlovic, Rada, Alexander, Allen A., Connors, Caroline Q., Newman, Diana, Mahmood, Javed, Eley, John, Harvey, Adam J., Kaytor, Michael D., Vujaskovic, Zeljko

“…To assess whether BIO 300, a synthetic genistein nanosuspension, improves the therapeutic index in prostate cancer treatment by preventing radiation-induced…”
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