Search Results - "Jackson, Dana"

Massively multiplex chemical transcriptomics at single-cell resolution by Srivatsan, Sanjay R, McFaline-Figueroa, José L, Ramani, Vijay, Saunders, Lauren, Cao, Junyue, Packer, Jonathan, Pliner, Hannah A, Jackson, Dana L, Daza, Riza M, Christiansen, Lena, Zhang, Fan, Steemers, Frank, Shendure, Jay, Trapnell, Cole

“…High-throughput chemical screens typically use coarse assays such as cell survival, limiting what can be learned about mechanisms of action, off-target…”
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Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures by Sridhar, Akshayalakshmi, Hoshino, Akina, Finkbeiner, Connor R., Chitsazan, Alex, Dai, Li, Haugan, Alexandra K., Eschenbacher, Kayla M., Jackson, Dana L., Trapnell, Cole, Bermingham-McDonogh, Olivia, Glass, Ian, Reh, Thomas A.

“…To study the development of the human retina, we use single-cell RNA sequencing (RNA-seq) at key fetal stages and follow the development of the major cell…”
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Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data by Pliner, Hannah A., Packer, Jonathan S., McFaline-Figueroa, José L., Cusanovich, Darren A., Daza, Riza M., Aghamirzaie, Delasa, Srivatsan, Sanjay, Qiu, Xiaojie, Jackson, Dana, Minkina, Anna, Adey, Andrew C., Steemers, Frank J., Shendure, Jay, Trapnell, Cole

“…Linking regulatory DNA elements to their target genes, which may be located hundreds of kilobases away, remains challenging. Here, we introduce Cicero, an…”
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Trajectory analysis quantifies transcriptional plasticity during macrophage polarization by Liu, Serena X., Gustafson, Heather H., Jackson, Dana L., Pun, Suzie H., Trapnell, Cole

“…In recent years, macrophages have been shown to be tremendously plastic in both in vitro and in vivo settings; however, it remains unclear whether macrophages…”
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Iodinated contrast media shortage: Insights and guidance from two major public hospitals by Amukotuwa, Shalini A, Bammer, Roland, Jackson, Dana M, Sutherland, Thomas

“…Summary Global shortage of iodinated contrast medium (ICM) is the latest health care ripple‐effect from the COVID‐19 pandemic. Some public hospitals in…”
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Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo by Dignum, Tessa, Varnum-Finney, Barbara, Srivatsan, Sanjay R., Dozono, Stacey, Waltner, Olivia, Heck, Adam M., Ishida, Takashi, Nourigat-McKay, Cynthia, Jackson, Dana L., Rafii, Shahin, Trapnell, Cole, Bernstein, Irwin D., Hadland, Brandon

“…During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem…”
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On the design of CRISPR-based single-cell molecular screens by Hill, Andrew J, McFaline-Figueroa, José L, Starita, Lea M, Gasperini, Molly J, Matreyek, Kenneth A, Packer, Jonathan, Jackson, Dana, Shendure, Jay, Trapnell, Cole

“…CRISPR-based single-cell pooled screens that use linked barcodes suffer from lost sensitivity due to lentiviral template switching. The barcode-free CROP-seq…”
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Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics by Hadland, Brandon, Varnum-Finney, Barbara, Dozono, Stacey, Dignum, Tessa, Nourigat-McKay, Cynthia, Heck, Adam M., Ishida, Takashi, Jackson, Dana L., Itkin, Tomer, Butler, Jason M., Rafii, Shahin, Trapnell, Cole, Bernstein, Irwin D.

“…Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic arterial vessels such as the aorta of the aorta-gonad-mesonephros region…”
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Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation by Bonora, Giancarlo, Ramani, Vijay, Singh, Ritambhara, Fang, He, Jackson, Dana L, Srivatsan, Sanjay, Qiu, Ruolan, Lee, Choli, Trapnell, Cole, Shendure, Jay, Duan, Zhijun, Deng, Xinxian, Noble, William S, Disteche, Christine M

“…Mammalian development is associated with extensive changes in gene expression, chromatin accessibility, and nuclear structure. Here, we follow such changes…”
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Proteostasis governs differential temperature sensitivity across embryonic cell types by Dorrity, Michael W, Saunders, Lauren M, Duran, Madeleine, Srivatsan, Sanjay R, Barkan, Eliza, Jackson, Dana L, Sattler, Sydney M, Ewing, Brent, Queitsch, Christine, Shendure, Jay, Raible, David W, Kimelman, David, Trapnell, Cole

“…Embryonic development is remarkably robust, but temperature stress can degrade its ability to generate animals with invariant anatomy. Phenotypes associated…”
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The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome by Yu, Shuyuarn F, Lujan, Phillip, Jackson, Dana L, Emerman, Michael, Linial, Maxine L

“…Viruses have to encapsidate their own genomes during the assembly process. For most RNA viruses, there are sequences within the viral RNA and virion proteins…”
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In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae by Tselepis, Lucas, Langley, Gareth W., Aboklaish, Ali F., Widlake, Emma, Jackson, Dana E., Walsh, Timothy R., Schofield, Chris J., Brem, Jürgen, Tyrrell, Jonathan M.

“…•AAI-101 (enmetazobactam) was shown to be a more effective class A β-lactamase inhibitor than the established clinical partner.•There was limited evidence of…”
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High‐throughput, microscope‐based sorting to dissect cellular heterogeneity by Hasle, Nicholas, Cooke, Anthony, Srivatsan, Sanjay, Huang, Heather, Stephany, Jason J, Krieger, Zachary, Jackson, Dana, Tang, Weiliang, Pendyala, Sriram, Monnat, Raymond J, Trapnell, Cole, Hatch, Emily M, Fowler, Douglas M

“…Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking these phenotypes to genotype or RNA expression at scale remains…”
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Reconstruction of frontal bone using patient specific implant poly-ether-ketone-ketone via a lateral nasal/lynch incision by Jackson, Dana, Obayomi, Temidayo, Mir, Francis

“…Trauma to the craniofacial structures can result in both functional and aesthetic defects. Mucosa lines the frontal sinus outflow tract (FSOT) from the frontal…”
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Mo-Si-B Coating for Improved Oxidation Resistance of Niobium by Lu-Steffes, Otto J., Su, Linfen, Jackson, Dana M., Perepezko, John H.

“…A Mo–Si–B based coating was applied to niobium that produced a coating structure composed of molybdenum and niobium silicides. Oxidation tests at 1000 °C and…”
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Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy by McFaline-Figueroa, José L., Srivatsan, Sanjay, Hill, Andrew J., Gasperini, Molly, Jackson, Dana L., Saunders, Lauren, Domcke, Silvia, Regalado, Samuel G., Lazarchuck, Paul, Alvarez, Sarai, Monnat, Raymond J., Shendure, Jay, Trapnell, Cole

“…Chemical genetic screens are a powerful tool for exploring how cancer cells’ response to drugs is shaped by their mutations, yet they lack a molecular view of…”
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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells by Mozin, Elise, Massouridès, Emmanuelle, Mournetas, Virginie, Lièvre, Clémence, Bourdon, Audrey, Jackson, Dana L., Packer, Jonathan S., Seong, Juyoung, Trapnell, Cole, Le Guiner, Caroline, Adjali, Oumeya, Pinset, Christian, Mack, David L., Dupont, Jean-Baptiste

“…Mutations in the DMD gene lead to Duchenne muscular dystrophy (DMD), a severe neuromuscular disorder affecting young boys as they acquire motor functions. DMD…”
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Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart by Read, David F., Booth, Gregory T., Daza, Riza M., Jackson, Dana L., Gladden, Rula Green, Srivatsan, Sanjay R., Ewing, Brent, Franks, Jennifer M., Spurrell, Cailyn H., Gomes, Anne Roshella, O’Day, Diana, Gogate, Aishwarya A., Martin, Beth K., Larson, Haleigh, Pfleger, Christian, Starita, Lea, Lin, Yiing, Shendure, Jay, Lin, Shin, Trapnell, Cole

“…Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for…”
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New World Simian Foamy Virus Infections In Vivo and In Vitro by Stenbak, Carolyn R, Craig, Karen L, Ivanov, Sergei B, Wang, Xiaoxing, Soliven, Khanh C, Jackson, Dana L, Gutierrez, Gustavo A, Engel, Gregory, Jones-Engel, Lisa, Linial, Maxine L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression of Prototype Foamy Virus Pol as a Gag-Pol Fusion Protein Does Not Change the Timing of Reverse Transcription by Jackson, Dana L, Lee, Eun-Gyung, Linial, Maxine L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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