Search Results - "Jackson, Clive G."

Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton by Connolly, Stephen, Bennion, Colin, Botterell, Sarah, Croshaw, Pamela J, Hallam, Catherine, Hardy, Kim, Hartopp, Paul, Jackson, Clive G, King, Sarah J, Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H, Smith, Gillian M, Stein, Linda, Walters, Iain, Wells, Edward, Withnall, W. John

“…Using knowledge of the substrate specificity of cPLA2 (phospholipases A2), a novel series of inhibitors of this enzyme were designed based upon a three point…”
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Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap by METE, Antonio, ANDREWS, Glen, ROBINSON, David H, SMITH, Gill M, WELLS, Edward, WITHNALL, W. John, BERNSTEIN, Mike, CONNOLLY, Stephen, HARTOPP, Paul, JACKSON, Clive G, LEWIS, Richard, MARTIN, Lain, MURRAY, David, RILEY, Rob

“…We report the design of novel, potent cPLA(2)α inhibitors that possess an α-methyl-2-ketothiazole that acts as a serine-reactive moiety. We describe the…”
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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors: reducing the lipophilicity of the arachidonyl chain isostere by WALTERS, Lain, BENNION, Colin, MURRAY, David, ROBINSON, David H, STEIN, Linda, WELLS, Edward, WITHNALL, W. John, CONNOLLY, Stephen, CROSHAW, Pamela J, HARDY, Kim, HARTOPP, Paul, JACKSON, Clive G, KING, Sarah J, LAWRENCE, Louise, METE, Antonio

“…The high lipophilicity of a series of cytosolic phospholipase A(2) inhibitors has been reduced by the modification of a decyloxyphenyl chain designed to mimic…”
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Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2 by Beaton, Haydn G, Bennion, Colin, Connolly, Stephen, Cook, Anthony R, Gensmantel, Nigel P, Hallam, Catherine, Hardy, Kim, Hitchin, Barbara, Jackson, Clive G, Robinson, David H

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The regulation by phosphorylation of ‘priming’ of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells by Stewart, Allison, Jackson, Clive G., Wakelam, Michael J. O.

“…1 Differentiated HL60 cells have been utilized as a model system to examine the ‘priming’ of neutrophil phospholipase A2 activity. In control cells activation…”
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Design and synthesis of some substrate analog inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex by Bennion, Colin, Connolly, Stephen, Gensmantel, Nigel P, Hallam, Catherine, Jackson, Clive G, Primrose, William U, Roberts, Gordon C. K, Robinson, David H, Slaich, Pritpal K

“…A series of substrate analogue inhibitors of pancreatic phospholipase A2 has been designed and synthesized. The compounds were tested in a novel dual-screening…”
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Monocarboxylate transporter MCT1 is a target for immunosuppression by Murray, Clare M, Hutchinson, Raymond, Bantick, John R, Belfield, Graham P, Benjamin, Amanda D, Brazma, Diana, Bundick, Robert V, Cook, I David, Craggs, Robert I, Edwards, Susan, Evans, Leslie R, Harrison, Richard, Holness, Elain, Jackson, Andrew P, Jackson, Clive G, Kingston, Lee P, Perry, Matthew W D, Ross, Andrew R J, Rugman, Paul A, Sidhu, Sasvinder S, Sullivan, Michael, Taylor-Fishwick, David A, Walker, P Craig, Whitehead, Yvonne M, Wilkinson, David J, Wright, Andrew, Donald, David K

“…Current immunosuppressive therapies act on T lymphocytes by modulation of cytokine production, modulation of signaling pathways or by inhibition of the enzymes…”
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The regulation by phosphorylation of ‘priming’ of phospholipase A 2 activity in the neutrophil model system, differentiated HL60 cells by Stewart, Allison, Jackson, Clive G., Wakelam, Michael J. O.

“…Differentiated HL60 cells have been utilized as a model system to examine the ‘priming’ of neutrophil phospholipase A 2 activity. In control cells activation…”
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Design of novel and potent cPLA sub(2 alpha inhibitors containing an alpha -methyl-2-ketothiazole as a metabolically stable serine trap) by Mete, Antonio, Andrews, Glen, Bernstein, Mike, Connolly, Stephen, Hartopp, Paul, Jackson, Clive G, Lewis, Richard, Martin, Iain, Murray, David, Riley, Rob, Robinson, David H, Smith, Gill M, Wells, Edward, Withnall, WJohn

“…We report the design of novel, potent cPLA sub(2 alpha inhibitors that possess an alpha -methyl-2-ketothiazole that acts as a serine-reactive moiety. We…”
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Design of novel and potent cPLA 2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap by Mete, Antonio, Andrews, Glen, Bernstein, Mike, Connolly, Stephen, Hartopp, Paul, Jackson, Clive G., Lewis, Richard, Martin, Iain, Murray, David, Riley, Rob, Robinson, David H., Smith, Gill M., Wells, Edward, Withnall, W. John

“…We report the design of novel, potent cPLA 2α inhibitors that possess an α-methyl-2-ketothiazole that acts as a serine-reactive moiety. We describe the…”
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Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton by Connolly, Stephen, Bennion, Colin, Botterell, Sarah, Croshaw, Pamela J, Hallam, Catherine, Hardy, Kim, Hartopp, Paul, Jackson, Clive G, King, Sarah J, Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H, Smith, Gillian M, Stein, Linda, Walters, Iain, Wells, Edward, Withnall, W John

“…Using knowledge of the substrate specificity of cPLA(2) (phospholipases A(2)), a novel series of inhibitors of this enzyme were designed based upon a three…”
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The isolation and purification of the elvapeptins by Bullough, David A., Jackson, Clive G., Henderson, Peter J.F., Beechey, R.Brian, Linnett, Paul E.

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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A 2 inhibitors––reducing the lipophilicity of the arachidonyl chain isostere by Walters, Iain, Bennion, Colin, Connolly, Stephen, Croshaw, Pamela J, Hardy, Kim, Hartopp, Paul, Jackson, Clive G, King, Sarah J, Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H, Stein, Linda, Wells, Edward, John Withnall, W

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Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation by Gilbert, JJ, Stewart, A, Courtney, CA, Fleming, MC, Reid, P, Jackson, CG, Wise, A, Wakelam, MJ, Harnett, MM

“…The Ag receptors on mature B and T cells are not coupled to the activation of cytosolic phospholipase A2 (cPLA2) and arachidonic acid release. Moreover,…”
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Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A 2 Based on a 1,3-Disubstituted Propan-2-one Skeleton by Connolly, Stephen, Bennion, Colin, Botterell, Sarah, Croshaw, Pamela J., Hallam, Catherine, Hardy, Kim, Hartopp, Paul, Jackson, Clive G., King, Sarah J., Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H., Smith, Gillian M., Stein, Linda, Walters, Iain, Wells, Edward, Withnall, W. John

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pHG165: a pBR322 copy number derivative of pUC8 for cloning and expression by Stewart, G S, Lubinsky-Mink, S, Jackson, C G, Cassel, A, Kuhn, J

“…During the construction of the Messing pUC plasmid series, the rop(rom) gene of pBR322 which mediates the activity of RNAI was deleted. This has resulted in an…”
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Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells by CURRIE, S, SMITH, G. L, CRICHTON, C. A, JACKSON, C. G, HALLAM, C, WAKELAM, M. J. O

“…In Swiss 3T3 fibroblasts bombesin stimulated the release of arachidonic acid in a time- and dose-dependent manner. Arachidonate levels were significantly…”
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The isolation and purification of the elvapeptins: A family of peptide inhibitors of mitochondrial ATPase activity by Bullough, David A., Jackson, Clive G., Henderson, Peter J.F., Beechey, R.Brian, Linnett, Paul E.

“…The mould, Tolypocladium inflatum has been shown to produce the efrapeptins, a family of closely related hydrophobic peptide anitibiotics, which are potent…”
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Purification and preliminary structural analysis of the efrapeptins, a group of antibiotics that inhibit the mitochondrial adenosine triphosphatase [proceedings] by Jackson, C G, Linnett, P E, Beechey, R B, Henderson, P J

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