Search Results - "Jackson, Christopher M"

Mechanisms of immunotherapy resistance: lessons from glioblastoma by Jackson, Christopher M., Choi, John, Lim, Michael

“…Glioblastoma (GBM) is the deadliest form of brain cancer, with a median survival of less than 2 years despite surgical resection, radiation, and chemotherapy…”
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Supercharged chimeric antigen receptor T cells in solid tumors by Pant, Ayush, Jackson, Christopher M

“…Chimeric antigen receptor (CAR) T cells have demonstrated success in treating select hematological malignancies, but their activity in solid tumors has been…”
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Dominant party politics and ethnic coordination after conflict: the Serb List in Kosovo by Jackson, Christopher M.

“…Since entering Kosovo politics in 2013, the Serb List (SL) monopolized political representation in the Kosovo Serb community. This study addresses dual…”
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Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM by Mathios, Dimitrios, Kim, Jennifer E, Mangraviti, Antonella, Phallen, Jillian, Park, Chul-Kee, Jackson, Christopher M, Garzon-Muvdi, Tomas, Kim, Eileen, Theodros, Debebe, Polanczyk, Magdalena, Martin, Allison M, Suk, Ian, Ye, Xiaobu, Tyler, Betty, Bettegowda, Chetan, Brem, Henry, Pardoll, Drew M, Lim, Michael

“…The immunosuppressive effects of chemotherapy present a challenge for designing effective cancer immunotherapy strategies. We hypothesized that although…”
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Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma by Maxwell, Russell, Jackson, Christopher M., Lim, Michael

“…Opinion statement Immune checkpoint inhibitors have changed the landscape of cancer immunotherapy and are being integrated into the standard of care for a…”
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Immunotherapy for Brain Cancer: Recent Progress and Future Promise by JACKSON, Christopher M, LIM, Michael, DRAKE, Charles G

“…Immunotherapy is emerging as the newest pillar of cancer treatment, with the potential to assume a place alongside surgical debulking, radiotherapy, and…”
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Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas by Zeng, Jing, MD, See, Alfred P., BS, Phallen, Jillian, BS, Jackson, Christopher M., BA, Belcaid, Zineb, MS, Ruzevick, Jacob, BS, Durham, Nicholas, BS, Meyer, Christian, MD, PhD, Harris, Timothy J., MD, PhD, Albesiano, Emilia, PhD, Pradilla, Gustavo, MD, Ford, Eric, PhD, Wong, John, PhD, Hammers, Hans-Joerg, MD, PhD, Mathios, Dimitris, MD, Tyler, Betty, BS, Brem, Henry, MD, Tran, Phuoc T., MD, PhD, Pardoll, Drew, MD, PhD, Drake, Charles G., MD, PhD, Lim, Michael, MD

“…Purpose Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and radiation is one of the main treatment modalities. However, cure…”
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Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo by Durham, Nicholas M, Nirschl, Christopher J, Jackson, Christopher M, Elias, Jimmy, Kochel, Christina M, Anders, Robert A, Drake, Charles G

“…Lymphocyte Activation Gene - 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular…”
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Combination anti-CXCR4 and anti-PD-1 immunotherapy provides survival benefit in glioblastoma through immune cell modulation of tumor microenvironment by Wu, Adela, Maxwell, Russell, Xia, Yuanxuan, Cardarelli, Pina, Oyasu, Miho, Belcaid, Zineb, Kim, Eileen, Hung, Alice, Luksik, Andrew S., Garzon-Muvdi, Tomas, Jackson, Christopher M., Mathios, Dimitrios, Theodros, Debebe, Cogswell, John, Brem, Henry, Pardoll, Drew M., Lim, Michael

“…Background Emerging evidence suggests that myeloid cells play a critical role in glioblastoma (GBM) immunosuppression. Disappointing results of recent…”
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The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke by Wicks, Elizabeth E., Ran, Kathleen R., Kim, Jennifer E., Xu, Risheng, Lee, Ryan P., Jackson, Christopher M.

“…The immune response to ischemic stroke is an area of study that is at the forefront of stroke research and presents promising new avenues for treatment…”
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Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma by Garzon-Muvdi, Tomas, Theodros, Debebe, Luksik, Andrew S, Maxwell, Russell, Kim, Eileen, Jackson, Christopher M, Belcaid, Zineb, Ganguly, Sudipto, Tyler, Betty, Brem, Henry, Pardoll, Drew M, Lim, Michael

“…The glioblastoma (GBM) immune microenvironment is highly suppressive as it targets and hinders multiple components of the immune system. Checkpoint blockade…”
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Synthesizing Molecular and Immune Characteristics to Move Beyond WHO Grade in Meningiomas: A Focused Review by Kannapadi, Nivedha V., Shah, Pavan P., Mathios, Dimitrios, Jackson, Christopher M.

“…No portion of this manuscript has previously been presented. Meningiomas, the most common primary intracranial tumors, are histologically categorized by the…”
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Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system by Maxwell, Russell, Luksik, Andrew S., Garzon-Muvdi, Tomas, Hung, Alice L., Kim, Eileen S., Wu, Adela, Xia, Yuanxuan, Belcaid, Zineb, Gorelick, Noah, Choi, John, Theodros, Debebe, Jackson, Christopher M., Mathios, Dimitrios, Ye, Xiaobu, Tran, Phuoc T., Redmond, Kristin J., Brem, Henry, Pardoll, Drew M., Kleinberg, Lawrence R., Lim, Michael

“…Immune checkpoint blockade targeting programmed cell death protein 1 (PD-1) is emerging as an important treatment strategy in a growing list of cancers, yet…”
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Immunotherapy for Glioblastoma: Playing Chess, Not Checkers by Jackson, Christopher M, Lim, Michael

“…Patients with glioblastoma (GBM) exhibit a complex state of immune dysfunction involving multiple mechanisms of local, regional, and systemic immunosuppression…”
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CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression by Luksik, Andrew S, Yazigi, Eli, Shah, Pavan, Jackson, Christopher M

“…Glioblastoma (GBM) is the most common primary brain tumor, yet prognosis remains dismal with current treatment. Immunotherapeutic strategies have had limited…”
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Ethnic Protection Rackets: Turkish Cypriot Statebuilding before 1974 by Jackson, Christopher M.

“…For the ten years prior to the Turkish partition of Cyprus into Greek and Turkish Cypriot zones, the Turkish Cypriot community lived in distinct ethnic…”
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Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas by Kim, Jennifer E, Patel, Mira A, Mangraviti, Antonella, Kim, Eileen S, Theodros, Debebe, Velarde, Esteban, Liu, Ann, Sankey, Eric W, Tam, Ada, Xu, Haiying, Mathios, Dimitrios, Jackson, Christopher M, Harris-Bookman, Sarah, Garzon-Muvdi, Tomas, Sheu, Mary, Martin, Allison M, Tyler, Betty M, Tran, Phuoc T, Ye, Xiaobu, Olivi, Alessandro, Taube, Janis M, Burger, Peter C, Drake, Charles G, Brem, Henry, Pardoll, Drew M, Lim, Michael

“…Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the…”
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Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities by Njonkou, Rosy, Jackson, Christopher M., Woodworth, Graeme F., Hersh, David S.

“…Pediatric glioblastoma is relatively rare compared with its adult counterpart but is associated with a similarly grim prognosis. Available data indicate that…”
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Linking to the State: Hierarchical Statebuilding After Ethnic Conflict in the Western Balkans by Jackson, Christopher M.

“…Fighting in Kosovo, Serbia, and Macedonia ended with internationally-sponsored settlements aimed at constituting unified states, but participatory politics by…”
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Therapeutic implications for the PD-1 axis in cerebrovascular injury by Feghali, James, Jackson, Christopher M.

“…Since the discovery and characterization of the PD-1/PD-L pathway, mounting evidence has emerged regarding its role in regulating neuroinflammation following…”
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