Search Results - "Jackman, A L"

Changes in calcium kinetics in adolescent girls induced by high calcium intake by WASTNEY, M. E, MARTIN, B. R, PEACOCK, M, SMITH, D, JIANG, X.-Y, JACKMAN, L. A, WEAVER, C. M

“…To identify the mechanism/s whereby calcium retention is increased by calcium intake in adolescent girls, kinetic studies were performed using stable calcium…”
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Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females by Jackman, LA, Millane, SS, Martin, BR, Wood, OB, McCabe, GP, Peacock, M, Weaver, CM

“…Achievement of maximal calcium retention during adolescence may influence the magnitude of peak bone mass and subsequently lower the risk of osteoporosis…”
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Folate-based thymidylate synthase inhibitors as anticancer drugs by Jackman, A L, Calvert, A H

“…The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover, the folate-binding site in TS…”
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The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition by WEBLEY, S. D, WELSH, S. J, JACKMAN, A. L, AHERNE, G. W

“…Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis…”
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Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents by Bavetsias, Vassilios, Marriott, Jonathan H, Melin, Camille, Kimbell, Rosemary, Matusiak, Zbigniew S, Boyle, F. Thomas, Jackman, Ann L

“…Following the development of raltitrexed, the synthesis of nonpolyglutamatable inhibitors of TS that do not use the reduced folate carrier (RFC) for cellular…”
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Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331 by WEBLEY, S. D, HARDCASTLE, A, LADNER, R. D, JACKMAN, A. L, AHERNE, G. W

“…Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. dUTPase catalyses…”
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Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase by JACKMAN, A. L, KIMBELL, R, AHERNE, G. W, BRUNTON, L, JANSEN, G, STEPHENS, T. C, SMITH, M. N, WARDLEWORTH, J. M, BOYLE, F. T

“…ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of thymidylate synthase (TS) that…”
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The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent by Bavetsias, V, Skelton, L. A, Yafai, F, Mitchell, F, Wilson, S. C, Allan, B, Jackman, A. L

“…4-[N-[7-Bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide (CB30865) is a quinazolin-4-one antitumor…”
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Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines by JACKMAN, A. L, KELLAND, L. R, KIMBELL, R, BROWN, M, GIBSON, W, AHERNE, G. W, HARDCASTLE, A, BOYLE, F. T

“…Four cell lines, the mouse L1210 leukaemia, the human W1L2 lymphoblastoid and two human ovarian (CH1 and 41M) cell lines, were made resistant to ZD1694…”
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Comparison of Thymidylate Synthase (TS) Protein Up-Regulation after Exposure to TS Inhibitors in Normal and Tumor Cell Lines and Tissues by WELSH, S. J, TITLEY, J, BRUNTON, L, VALENTI, M, MONAGHAN, P, JACKMAN, A. L, AHERNE, G. W

“…Thymidylate synthase (TS) is an important target for cancer chemotherapy. However, several mechanisms of resistance to TS inhibitors have been described. One…”
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Nonpolyglutamatable antifolates as inhibitors of thymidylate synthase (TS) and potential antitumour agents by Bavetsias, V, Jackman, A L

“…Thymidylate synthase (TS), an enzyme that catalyses the conversion of dUMP to dTMP, has been the focus of interest as a target in cancer chemotherapy for more…”
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Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors by Clarke, S J, Hanwell, J, de Boer, M, Planting, A, Verweij, J, Walker, M, Smith, R, Jackman, A L, Hughes, L R, Harrap, K R, Kennealey, G T, Judson, I R

“…To perform a phase I clinical and pharmacologic study of ZD1694 (Tomudex, Alderley Park, United Kingdom), a new folate-based thymidylate synthase (TS)…”
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Leucovorin Rescue from Raltitrexed (Tomudex)-induced Antiproliferative Effects: In Vitro Cell Line and in Vivo Mouse Studies by FARRUGIA, D. C, AHERNE, G. W, BRUNTON, L, CLARKE, S. J, JACKMAN, A. L

“…Raltitrexed (RTX) is an antifolate thymidylate synthase (TS) inhibitor that is effective for the treatment of advanced colorectal cancer and other solid…”
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bcl-2 Modulation of apoptosis induced by anticancer drugs : resistance to thymidylate stress is independent of classical resistance pathways by FISHER, T. C, MILNER, A. E, GREGORY, C. D, JACKMAN, A. L, ABERNE, G. W, HARTLEY, J. A, DIVE, C, HICKMAN, J. A

“…The hypothesis was tested that expression of bcl-2 could provide protection against apoptosis induced by cytotoxic drugs via a mechanism which was different…”
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Balb/c Mice as a Preclinical Model for Raltitrexed-induced Gastrointestinal Toxicity by CLARKE, S. J, FARRUGIA, D. C, AHERNE, G. W, PRITCHARD, D. M, BENSTEAD, J, JACKMAN, A. L

“…Raltitrexed (RTX) is an antifolate thymidylate synthase (TS) inhibitor used for the treatment of advanced colorectal cancer. RTX induces proliferating tissue…”
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Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors by Marsham, Peter R, Wardleworth, J. Michael, Boyle, F. Thomas, Hennequin, Laurent F, Kimbell, Rosemary, Brown, Melody, Jackman, Ann L

“…The synthesis is described of a series of analogues of the potent thymidylate synthase (TS) inhibitor,…”
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A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus by SKELTON, L. A, ORMEROD, M. G, TITLEY, J, KIMBELL, R, BRUNTON, L. A, JACKMAN, A. L

“…Three lipophilic quinazoline-based aminomethyl pyridine compounds, which differ only in the position of the nitrogen in their pyridine ring, are described…”
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ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer by Jackman, A.L, Farrugia, D.C, Gibson, W, Kimbell, R, Harrap, K.R, Stephens, T.C, Azab, M, Boyle, F.T

“…ZD1694 (Tomudex) is a new antifolate which is a specific inhibitor of thymidylate synthase (TS). Evidence suggests that ZD1694 has a spectrum of activity that…”
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Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models by AHERNE, G. W, WARD, E, LAWRENCE, N, DOBINSON, D, CLARKE, S. J, MUSGROVE, H, SUTCLIFFE, F, STEPHENS, T, JACKMAN, A. L

“…ZD1694 (Tomudex, raltitrexed) is a specific quinazoline antifolate thymidylate synthase inhibitor that relies on polyglutamation for high potency. Antibodies…”
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Cyclopenta[ g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS) by Bavetsias, V., Marriott, J.H., Theti, D.S., Melin, J.C., Wilson, S.C., Jackman, A.L.

“…Cyclopenta[ g]quinazoline-based inhibitors of thymidylate synthase (TS) possess a chiral centre at the 6-position of the molecule. The effect of this chirality…”
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