Search Results - "Jack, Melissa T"

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response by Jack, Melissa T, Woo, Richard A, Hirao, Atsushi, Cheung, Alison, Mak, Tak W, Lee, Patrick W K

“…In response to genotoxic stress, mammalian cells can activate cell cycle checkpoint pathways to arrest the cell for repair of DNA damage or induce apoptosis to…”
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DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage by Jack, Melissa T., Woo, Richard A., Motoyama, Noboru, Takai, Hitoyuki, Lee, Patrick W.K.

“…The role of the checkpoint kinase 2 (Chk2) as an upstream activator of p53 following DNA damage has been controversial. We have recently shown that Chk2 and…”
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DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53 by Woo, Richard A., Jack, Melissa T., Xu, Yang, Burma, Sandeep, Chen, David J., Lee, Patrick W.K.

“…Mouse embryo fibroblasts (MEFs) expressing the adenovirus E1A protein undergo apoptosis upon exposure to ionizing radiation. We show here that immediately…”
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Chk2 is dispensible for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response by Jack, Melissa T, Woo, Richard A, Hirao, Atsushi, Cheung, Alison

“…In response to genotoxic stress, mammalian cells can activate cell cycle checkpoint pathways to arrest the cell for repair of DNA damage or induce apoptosis to…”
Get full text

DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53 by Woo, Richard A, Jack, Melissa T, Xu, Yang, Burma, Sandeep, Chen, David J, Lee, Patrick W K

“…Correction to: The EMBO Journal (2002) 21, 3000-3008. doi: 10.1093/emboj/cdf307…”
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Chk2 is Dispensable for p53-Mediated G1Arrest but is Required for a Latent p53-Mediated Apoptotic Response by Jack, Melissa T., Woo, Richard A., Hirao, Atsushi, Cheung, Alison, Mak, Tak W., Patrick W. K. Lee

“…In response to genotoxic stress, mammalian cells can activate cell cycle checkpoint pathways to arrest the cell for repair of DNA damage or induce apoptosis to…”
Get full text

Chk2 is dispensable for p53-mediated G 1 arrest but is required for a latent p53-mediated apoptotic response by Jack, Melissa T., Woo, Richard A., Hirao, Atsushi, Cheung, Alison, Mak, Tak W., Lee, Patrick W. K.

“…In response to genotoxic stress, mammalian cells can activate cell cycle checkpoint pathways to arrest the cell for repair of DNA damage or induce apoptosis to…”
Get full text