Human papillomavirus genotypes distribution in cervical samples from women living with human immunodeficiency virus

Human papillomavirus genotypes distribution in cervical samples from women living with human immunodeficiency virus

Background The aim of this study was to determine the prevalence and relationship of human papillomavirus (HPV) genotypes in cervical samples from 140 human immunodeficiency virus (HIV)-seropositive women routinely attending an outpatient public gynecological service in the state of Rio de Janeiro,...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics Vol. 283; no. 4; pp. 809 - 817
Main Authors: Melgaço, Fabiana G., Rosa, Maria L. G., Augusto, Everton F., Haimuri, Jacqueline G. S., Jacintho, Claudia, Santos, Larissa S., Cavalcanti, Silvia M. B., Oliveira, Ledy H. S.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-04-2011
Springer Nature B.V
Subjects:
Adolescent
Adult
Alphapapillomavirus - genetics
Brazil - epidemiology
Cervical cancer
Cervix Uteri - virology
Cohort analysis
Comorbidity
Cross-Sectional Studies
Endocrinology
Female
General Gynecology
Genotype
Gynecology
HIV
HIV Infections - complications
HIV Infections - epidemiology
Human Genetics
Human immunodeficiency virus
Human papillomavirus
Humans
Medicine
Medicine & Public Health
Middle Aged
Obstetrics/Perinatology/Midwifery
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Vaginal Smears
Young Adult
Brazil
Human papillomavirus
Restriction fragment length polymorphism
Human immunodeficiency virus
Cohort study
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Summary:Background The aim of this study was to determine the prevalence and relationship of human papillomavirus (HPV) genotypes in cervical samples from 140 human immunodeficiency virus (HIV)-seropositive women routinely attending an outpatient public gynecological service in the state of Rio de Janeiro, Brazil. Methods MY09/11 consensus primers were used to detect generic HPV DNA. HPV typification was performed by restriction fragment length polymorphism analysis following polymerase chain reaction amplification. Results The overall HPV prevalence was 60.0%. The identification of 24 different HPV genotypes including uncommon types was performed. A9 oncogenic genotypes were present in 54.02% of HIV-positive women. Abnormal cervical lesions, the time since HIV diagnosis and the number of sexual partners contributed independently to the high oncogenic HPV prevalence. The oncogenic and non-oncogenic group were similarly affected by risk factors in contrast to negative HPV women. The frequency of multiple infections was 20%; furthermore, all of them presented at least one oncogenic type. Conclusion The analyzed sample represents an epidemiological source of uncommon infection. Due to high HPV prevalence, more frequent cytological screening and/or liberal colposcopic evaluations should be performed in HIV-positive patients.
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ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-010-1443-z