Search Results - "Jacek, Karol"
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Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression
Published in Cell reports (Cambridge) (31-01-2023)“…Malignant gliomas are aggressive, hard-to-treat brain tumors. Their tumor microenvironment is massively infiltrated by myeloid cells, mostly brain-resident…”
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Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions
Published in International journal of molecular sciences (01-09-2021)“…The biology and chemistry of proteins and peptides are inextricably linked with water as the solvent. The reason for the high stability of some proteins or…”
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Targeted sequencing of cancer‐related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma
Published in International journal of cancer (01-09-2023)“…High‐grade gliomas are aggressive, deadly primary brain tumors. Median survival of patients with glioblastoma (GBM, WHO grade 4) is 14 months and <10% of…”
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DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma
Published in Cell death & disease (20-03-2024)“…Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance survival times…”
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Bacterial community dynamics in spontaneous sourdoughs made from wheat, spelt, and rye wholemeal flour
Published in MicrobiologyOpen (Weinheim) (01-04-2020)“…Sourdough fermentation is a traditional process that is used to improve bread quality. A spontaneous sourdough ecosystem consists of a mixture of flour and…”
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812 Reprograming of tumor-associated myeloid cells by TLR9-targeted STAT3 antisense oligonucleotides sensitizes malignant glioma to PD1-specific immunotherapy
Published in Journal for immunotherapy of cancer (01-11-2023)“…BackgroundMalignant gliomas (MG) are rapidly fatal despite multimodal treatments including radiation therapy, used to treat nearly all MG patients, or even the…”
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TMIC-22. INTERPLAY BETWEEN GBM AND IMMUNE CELLS IN THE MOUSE GLIOMA MICROENVIRONMENT AT SINGLE-CELL RESOLUTION
Published in Neuro-oncology (Charlottesville, Va.) (14-11-2022)“…Glioblastoma (GBM) is the most common primary tumor of the central nervous system in adults. GBM patients have a particularly poor prognosis and extremely…”
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TMIC-83. SEX AND ANTI-GLIOMA IMMUNITY
Published in Neuro-oncology (Charlottesville, Va.) (14-11-2022)“…Glioblastomas (GBMs) are aggressive, inevitably lethal brain tumors that are massively infiltrated by myeloid cells supporting tumor growth. The main myeloid…”
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TMIC-38. INTEGRIN BLOCKING PEPTIDE REPROGRAMS THE IMMUNOSUPPRESSIVE MICROENVIRONMENT OF EXPERIMENTAL GLIOMAS IMPROVING ANTI-PD-1 THERAPY OUTCOME
Published in Neuro-oncology (Charlottesville, Va.) (11-11-2024)“…Clinical trials with immune checkpoint inhibitors (ICI) have benefited many cancer patients but failed in a number of tumors, including glioblastoma (GBM), the…”
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Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain
Published in Applied microbiology and biotechnology (01-07-2017)“…The ability of Lactococcus lactis to adhere to the intestinal mucosa can potentially prolong the contact with the host, and therefore favour its persistence in…”
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Bi-functional CpG-STAT3 decoy oligonucleotide triggers multilineage differentiation of acute myeloid leukemia in mice
Published in Molecular therapy. Nucleic acids (10-09-2024)“…Acute myeloid leukemia (AML) cells resist differentiation stimuli despite high expression of innate immune receptors, such as Toll-like receptor 9 (TLR9). We…”
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Adhesion of the genome-sequenced Lactococcus lactis subsp. cremoris IBB477 strain is mediated by specific molecular determinants
Published in Applied microbiology and biotechnology (01-11-2016)“…Understanding the nature of mucus-microbe interactions will provide important information that can help to elucidate the mechanisms underlying probiotic…”
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下肢慢性缺血患者的超重和肥胖对血浆中VEGF-A、VEGFR-1和VEGFR-2浓度的影响
Published in 浙江大学学报:B卷英文版 (2016)“…目的:研究外周动脉疾病(PAD)患者血浆中血管内皮生长因子A(VEGF-A)和它的可溶性1型和2型受体(sV EGFR-1和sV…”
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2型糖尿病对外周动脉疾病患者血浆内的血管内皮生长因子及其可溶性受体浓度的影响
Published in 浙江大学学报:B卷英文版 (2015)“…目的:研究2型糖尿病对外周动脉疾病患者血浆内的血管内皮生长因子(VEGF—A)及其水溶性受体(sVEGFR-1和sVEGFR-2)浓度的影响。 创新点:首次研究了2型糖尿病对外周动脉疾病患者血浆内sVEGFR-1和sVEGFR-2浓度的影响。…”
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