Search Results - "Jablons, DM"

Scientific Advances and New Frontiers in Mesothelioma Therapeutics by Mutti, Luciano, Peikert, Tobias, Robinson, Bruce W S, Scherpereel, Arnaud, Tsao, Anne S, de Perrot, Marc, Woodard, Gavitt A, Jablons, David M, Wiens, Jacinta, Hirsch, Fred R, Yang, Haining, Carbone, Michele, Thomas, Anish, Hassan, Raffit

“…Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that arises from the mesothelial surface of the pleural and peritoneal cavities, the…”
Get more information

Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer by JOHNSON, David H, FEHRENBACHER, Louis, HOLMGREN, Eric, KABBINAVAR, Fairooz, NOVOTNY, William F, HERBST, Roy S, NEMUNAITIS, John J, JABLON, David M, LANGER, Corey J, DEVORE, Russell F, GAUDREAULT, Jacques, DAMICO, Lisa A

“…To investigate the efficacy and safety of bevacizumab plus carboplatin and paclitaxel in patients with advanced or recurrent non-small-cell lung cancer. In a…”
Get full text

Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion by Dresler, Carolyn M, Olak, Jemi, Herndon, 2nd, James E, Richards, William G, Scalzetti, Ernest, Fleishman, Stewart B, Kernstine, Kemp H, Demmy, Todd, Jablons, David M, Kohman, Leslie, Daniel, Thomas M, Haasler, George B, Sugarbaker, David J

“…To demonstrate the efficacy, safety, and appropriate mode of instillation of talc for sclerosis in treatment of malignant pleural effusions (MPEs). A…”
Get more information

Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression by UEMATSU, Kazutsugu, BIAO HE, LIANG YOU, ZHIDONG XU, MCCORMICK, Frank, JABLONS, David Mark

“…Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United States and worldwide. Unfortunately, standard therapies remain…”
Get full text

Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer by MAZIERES, Julien, BIAO HE, LIANG YOU, ZHIDONG XU, LEE, Amie Y, MIKAMI, Iwao, REGUART, Noemi, ROSELL, Rafael, MCCORMICK, Frank, JABLONS, David M

“…Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety of human cancers, and we recently reported the importance of…”
Get full text

SOCS-3 Is Frequently Silenced by Hypermethylation and Suppresses Cell Growth in Human Lung Cancer by He, Biao, You, Liang, Uematsu, Kazutsugu, Zang, Keling, Xu, Zhidong, Lee, Amie Y., Costello, Joseph F., McCormick, Frank, Jablons, David M.

“…Lung cancer is the leading cause of cancer death in the world, but the molecular mechanisms for its development have not been well characterized. The…”
Get full text

Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations by BIAO HE, REGUART, Noemi, LIANG YOU, MAZIERES, Julien, ZHIDONG XU, LEE, Amie Y, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…Aberrant Wnt signaling, mainly through mutations of APC and in some cases of CTNNB1 or AXIN2, has been found in the majority of colorectal cancers. Recently,…”
Get full text

Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells by LIANG YOU, BIAO HE, JABLONS, David M, ZHIDONG XU, UEMATSU, Kazutsugu, MAZIERES, Julien, MIKAMI, Iwao, REGUART, Noemi, MOODY, Terry W, KITAJEWSKI, Jan, MCCORMICK, Frank

“…In this report, we have demonstrated that Wnt-2 protein is overexpressed in freshly resected human non-small-cell lung cancer (NSCLC) tissues. We have also…”
Get full text

A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells by He, Biao, You, Liang, Uematsu, Kazutsugu, Xu, Zhidong, Lee, Amie Y., Matsangou, Maria, McCormick, Frank, Jablons, David M.

“…Aberrant activation of the Wingless-type (Wnt)/β-catenin signaling pathway is associated with a variety of human cancers. Little is known regarding the role…”
Get full text

Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma by LEE, Amie Y, BIAO HE, LIANG YOU, DADFARMAY, Sina, ZHIDONG XU, MAZIERES, Julien, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…Secreted frizzled-related proteins (sFRPs) comprise a family of five secreted glycoproteins that antagonize Wnt signaling. Aberrant activation and upregulation…”
Get full text

An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth by LIANG YOU, BIAO HE, MCCORMICK, Frank, JABLONS, David M, ZHIDONG XU, UEMATSU, Kazutsugu, MAZIERES, Julien, FUJII, Naoaki, MIKAMI, Iwao, REGUART, Noemi, MCINTOSH, Joe K, KASHANI-SABET, Mohammed

“…Activation of the Wnt/beta-catenin signaling pathway has been associated with human cancers. To test whether Wnt-2 signal is a survival factor in human…”
Get full text

Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET by Wang, Zhen J, Reddy, Gautham P, Gotway, Michael B, Higgins, Charles B, Jablons, David M, Ramaswamy, Mohan, Hawkins, Randall A, Webb, W Richard

“…Imaging plays an essential role in the evaluation of malignant pleural mesothelioma (MPM). Computed tomography is the primary imaging modality used for the…”
Get full text

Wnt pathway activation in mesothelioma: Evidence of dishevelled overexpression and transcriptional activity of β-catenin by UEMATSU, Kazutsugu, KANAZAWA, Satoshi, LIANG YOU, BIAO HE, ZHIDONG XU, KAI LI, PETERLIN, B. Matija, MCCORMICK, Frank, JABLONS, David M

“…Malignant pleural mesothelioma is a relatively uncommon and yet incurable tumor. The pathogenesis of mesothelioma remains poorly understood. This study…”
Get full text

Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in β-catenin-deficient human mesothelioma cells by BIAO HE, LEE, Amie Y, DADFARMAY, Sina, LIANG YOU, ZHIDONG XU, REGUART, Noemi, MAZIERES, Julien, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in tumorigenesis. Frequent…”
Get full text

Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis by MAZIERES, Julien, LIANG YOU, BIAO HE, ZHIDONG XU, LEE, Amie Y, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…The Wnt family of secreted glycoproteins is widely involved in cell proliferation, differentiation and oncogenesis. Many Wnt signaling genes are upregulated…”
Get full text

Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma by Jiang, Long, Tolani, Bhairavi, Yeh, Che-Chung, Fan, Yanying, Reza, Joseph A, Horvai, Andrew E, Xia, Endi, Kratz, Johannes R, Jablons, David M, Mann, Michael J

“…Despite numerous discoveries regarding the molecular genesis and progression of primary cancers, the biology of metastasis remains poorly understood. Compared…”
Get full text

Dickkopf-1 antagonizes Wnt signaling independent of β-catenin in human mesothelioma by Lee, Amie Y., He, Biao, You, Liang, Xu, Zhidong, Mazieres, Julien, Reguart, Noemi, Mikami, Iwao, Batra, Sonny, Jablons, David M.

“…Dickkopf-1 (Dkk-1) is a secreted protein that acts as a potent inhibitor of the Wnt signal transduction pathway. It is thought that the antagonistic effect of…”
Get full text

Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma by Batra, Sonny, Shi, Yihui, Kuchenbecker, Kristopher M., He, Biao, Reguart, Noemi, Mikami, Iwao, You, Liang, Xu, Zhidong, Lin, Yu-Ching, Clément, Geneviève, Jablons, David M.

“…Wnt inhibitory factor-1 (WIF-1) is a secreted protein that antagonizes Wnt signaling. We recently demonstrated the importance of aberrant activation of the Wnt…”
Get full text

Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: Implications of the phosphatidylinositol 3-kinase pathway by MASSION, Pierre P, KUO, Wen-Lin, ALBERTSON, Donna G, JABLONS, David M, GRAY, Joe W, STOKOE, David, OLSHEN, Adam B, TRESELER, Patrick A, KOEI CHIN, CHIRA CHEN, POLIKOFF, Daniel, JAIN, Ajay N, PINKEL, Daniel

“…Genomic abnormalities at 348 loci encoding genes that may contribute to lung cancer transformation and progression were assessed using array comparative…”
Get full text

Inhibition of Wnt-1 signaling induces apoptosis in β-catenin-deficient mesothelioma cells by LIANG YOU, BIAO HE, UEMATSU, Kazutsugu, ZHIDONG XU, MAZIERES, Julien, LEE, Amie, MCCORMICK, Frank, JABLONS, David M

“…It is known that Wnt-1 signaling inhibits apoptosis by activating beta-catenin/tcf-mediated transcription. Here, we show that blocking Wnt-1 signaling in…”
Get full text