Corynebacterium Species Inhibit Streptococcus pneumoniae Colonization and Infection of the Mouse Airway
The stability and composition of the airway microbiome is an important determinant of respiratory health. Some airway bacteria are considered to be beneficial due to their potential to impede the acquisition and persistence of opportunistic bacterial pathogens such as . Among such organisms, the pre...
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| Published in: | Frontiers in microbiology Vol. 12; p. 804935 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
10-01-2022
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The stability and composition of the airway microbiome is an important determinant of respiratory health. Some airway bacteria are considered to be beneficial due to their potential to impede the acquisition and persistence of opportunistic bacterial pathogens such as
. Among such organisms, the presence of
species correlates with reduced
in both adults and children, in whom
abundance is predictive of
infection risk. Previously,
was shown to express a lipase which cleaves host lipids, resulting in the production of fatty acids that inhibit growth of
. However, it was unclear whether this mechanism contributes to
-
interactions
. To address this question, we developed a mouse model for
colonization in which colonization with either
or another species,
, significantly reduced
acquisition in the upper airway and infection in the lung. Moreover, the lungs of co-infected mice had reduced pro-inflammatory cytokines and inflammatory myeloid cells, indicating resolution of infection-associated inflammation. The inhibitory effect of
on
was mediated by lipase-dependent and independent effects, indicating that both this and other bacterial factors contribute to
-mediated protection in the airway. We also identified a previously uncharacterized bacterial lipase in
that is required for inhibition of
growth
. Together, these findings demonstrate the protective potential of airway
species and establish a new model for investigating the impact of commensal microbiota, such as
, on maintaining respiratory health. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Rustam Aminov, University of Aberdeen, United Kingdom Reviewed by: Anders P. Hakansson, Lund University, Sweden; Cassius Souza, Rio de Janeiro State University, Brazil This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology |
| ISSN: | 1664-302X 1664-302X |
| DOI: | 10.3389/fmicb.2021.804935 |