Metabolomics – A robust bioanalytical approach for the discovery of the modes-of-action of pesticides: A review

The agrochemical industry is facing great undertaking that includes increasing demand for the development of new crop protection agents that are safe for the environment and the consumers, and at the same time combat the issue of the emergence of resistance pest strains. The mode-of-action (MoA) is...

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Published in:	Pesticide biochemistry and physiology Vol. 100; no. 2; pp. 105 - 117
Main Authors:	Aliferis, Konstantinos A, Jabaj, Suha
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-06-2011 Elsevier
Subjects:	Acaricides Agrochemicals Antibiotics Bioactive compounds Biological and medical sciences Consumers Crop protection Functional genomics Fungicides Herbicides industry Insecticides Metabolic profiling metabolomics Natural products pest resistance Pesticides Pests plant protection research and development Reviews scientists screening FT-ICR/MS MS PSII AHAS HPLC-ESI/MS PSI ALS LC-TOF/MS ACCase 1H NMR PLS-DA Crop protection 4-HPPD PPO PCA Metabolic profiling Bioactive compounds Natural products EPSPS PEP GC/MS MoA PDS Functional genomics Metabolomics Biochemical analysis Methodology Metabolite Biochemical compound Pesticides Natural product Biochemistry Review Discoveries Metabolism Biological activity Biological compound Bioanalysis Approach Molecular biology Mechanism of action
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Summary:	The agrochemical industry is facing great undertaking that includes increasing demand for the development of new crop protection agents that are safe for the environment and the consumers, and at the same time combat the issue of the emergence of resistance pest strains. The mode-of-action (MoA) is among the features of a bioactive compound that largely determine whether the abovementioned issues are addressed or not, and subsequently whether its commercial development will be addressed. The early discovery of the MoA of bioactive compounds could accelerate pesticide research and development by reducing the required time and costs. Based on advances in synthetic and natural product chemistry, scientists have access to a vast number of compounds that could potentially be developed as crop protection agents. The screening of such compounds with respect to their MoA requires accurate and robust bioanalytical tools. Metabolomics is a powerful bioanalytical tool that will likely play a significant role in the acceleration of the discovery of MoA of bioactive compounds. In the present review, the capabilities and principles and applications of metabolomics for the study of the MoA of herbicides, insecticides, acaricides, fungicides, and antibiotics are discussed.
Bibliography:	http://dx.doi.org/10.1016/j.pestbp.2011.03.004 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0048-3575 1095-9939
DOI:	10.1016/j.pestbp.2011.03.004