Search Results - "Jabado, Nada"

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism by Jain, Siddhant U., Do, Truman J., Lund, Peder J., Rashoff, Andrew Q., Diehl, Katharine L., Cieslik, Marcin, Bajic, Andrea, Juretic, Nikoleta, Deshmukh, Shriya, Venneti, Sriram, Muir, Tom W., Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.

“…Posterior fossa type A (PFA) ependymomas exhibit very low H3K27 methylation and express high levels of EZHIP (Enhancer of Zeste Homologs Inhibitory Protein,…”
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Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas by Khan, Aaminah, Gamble, Laura D., Upton, Dannielle H., Ung, Caitlin, Yu, Denise M. T., Ehteda, Anahid, Pandher, Ruby, Mayoh, Chelsea, Hébert, Steven, Jabado, Nada, Kleinman, Claudia L., Burns, Mark R., Norris, Murray D., Haber, Michelle, Tsoli, Maria, Ziegler, David S.

“…Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than…”
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Entering the era of precision medicine in pediatric oncology by Hadjadj, Djihad, Deshmukh, Shriya, Jabado, Nada

“…The Zero Childhood Cancer Program’s multi-platform sequencing approach identified molecular alterations in 94% of a cohort of 247 pediatric patients with…”
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The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape by Weinberg, Daniel N., Papillon-Cavanagh, Simon, Chen, Haifen, Yue, Yuan, Chen, Xiao, Rajagopalan, Kartik N., Horth, Cynthia, McGuire, John T., Xu, Xinjing, Nikbakht, Hamid, Lemiesz, Agata E., Marchione, Dylan M., Marunde, Matthew R., Meiners, Matthew J., Cheek, Marcus A., Keogh, Michael-Christopher, Bareke, Eric, Djedid, Anissa, Harutyunyan, Ashot S., Jabado, Nada, Garcia, Benjamin A., Li, Haitao, Allis, C. David, Majewski, Jacek, Lu, Chao

“…Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian…”
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A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01 by Perreault, Sébastien, Larouche, Valérie, Tabori, Uri, Hawkin, Cynthia, Lippé, Sarah, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Caru, Maxime, Legault, Geneviève, Bouffet, Éric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada

“…Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known…”
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Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas by Papillon-Cavanagh, Simon, Lu, Chao, Gayden, Tenzin, Mikael, Leonie G, Bechet, Denise, Karamboulas, Christina, Ailles, Laurie, Karamchandani, Jason, Marchione, Dylan M, Garcia, Benjamin A, Weinreb, Ilan, Goldstein, David, Lewis, Peter W, Dancu, Octavia Maria, Dhaliwal, Sandeep, Stecho, William, Howlett, Christopher J, Mymryk, Joe S, Barrett, John W, Nichols, Anthony C, Allis, C David, Majewski, Jacek, Jabado, Nada

“…Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3 genes causing recurrent p.Lys36Met alterations in head and neck squamous…”
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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas by Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, Hawkins, Cynthia

“…Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated…”
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Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression by Jain, Siddhant U., Khazaei, Sima, Marchione, Dylan M., Lundgren, Stefan M., Wang, Xiaoshi, Weinberg, Daniel N., Deshmukh, Shriya, Juretic, Nikoleta, Lu, Chao, Allis, C. David, Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.

“…A high percentage of pediatric gliomas and bone tumors reportedly harbor missense mutations at glycine 34 in genes encoding histone variant H3.3. We find that…”
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma by Nikbakht, Hamid, Panditharatna, Eshini, Mikael, Leonie G., Li, Rui, Gayden, Tenzin, Osmond, Matthew, Ho, Cheng-Ying, Kambhampati, Madhuri, Hwang, Eugene I., Faury, Damien, Siu, Alan, Papillon-Cavanagh, Simon, Bechet, Denise, Ligon, Keith L., Ellezam, Benjamin, Ingram, Wendy J., Stinson, Caedyn, Moore, Andrew S., Warren, Katherine E., Karamchandani, Jason, Packer, Roger J., Jabado, Nada, Majewski, Jacek, Nazarian, Javad

“…Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address…”
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Pediatric high-grade glioma: biologically and clinically in need of new thinking by Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

“…High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed…”
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H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation by Harutyunyan, Ashot S., Chen, Haifen, Lu, Tianyuan, Horth, Cynthia, Nikbakht, Hamid, Krug, Brian, Russo, Caterina, Bareke, Eric, Marchione, Dylan M., Coradin, Mariel, Garcia, Benjamin A., Jabado, Nada, Majewski, Jacek

“…The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this…”
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BRAF KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma by HAWKING, Cynthia, WALKER, Erin, TSANGARIS, Elena, DIRKS, Peter, TRESSLER, Robert, BOUFFET, Eric, JABADO, Nada, TABORI, Uri, MOHAMED, Nequesha, ZHANG, Cindy, JACOB, Karine, SHIRINIAN, Margret, ALON, Noa, KAHN, Daniel, FRIED, Iris, SCHEINEMANN, Katrin

“…Recent studies have revealed that the majority of pediatric low-grade astrocytomas (PLGA) harbor the BRAF-KIAA1549 (B-K) fusion gene resulting in constitutive…”
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Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations by Liu, Xiao-Yang, Gerges, Noha, Korshunov, Andrey, Sabha, Nesrin, Khuong-Quang, Dong-Anh, Fontebasso, Adam M., Fleming, Adam, Hadjadj, Djihad, Schwartzentruber, Jeremy, Majewski, Jacek, Dong, Zhifeng, Siegel, Peter, Albrecht, Steffen, Croul, Sidney, Jones, David TW, Kool, Marcel, Tonjes, Martje, Reifenberger, Guido, Faury, Damien, Zadeh, Gelareh, Pfister, Stefan, Jabado, Nada

“…Gliomas are the most common primary brain tumors in children and adults. We recently identified frequent alterations in chromatin remodelling pathways…”
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An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation by Le Guen, Tangui, PhD, Touzot, Fabien, MD, PhD, André-Schmutz, Isabelle, PhD, Lagresle-Peyrou, Chantal, PhD, France, Benoit, MSc, Kermasson, Laetitia, Lambert, Nathalie, Picard, Capucine, MD, PhD, Nitschke, Patrick, PhD, Carpentier, Wassila, PhD, Bole-Feysot, Christine, PhD, Lim, Annick, PhD, Cavazzana, Marina, MD, PhD, Callebaut, Isabelle, PhD, Soulier, Jean, MD, PhD, Jabado, Nada, MD, PhD, Fischer, Alain, MD, PhD, de Villartay, Jean-Pierre, PhD, Revy, Patrick, PhD

“…Background Myb-Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiquitinated form of histone 2A (H2A), a…”
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Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas by Fontebasso, Adam M., Schwartzentruber, Jeremy, Khuong-Quang, Dong-Anh, Liu, Xiao-Yang, Sturm, Dominik, Korshunov, Andrey, Jones, David T. W., Witt, Hendrik, Kool, Marcel, Albrecht, Steffen, Fleming, Adam, Hadjadj, Djihad, Busche, Stephan, Lepage, Pierre, Montpetit, Alexandre, Staffa, Alfredo, Gerges, Noha, Zakrzewska, Magdalena, Zakrzewski, Krzystof, Liberski, Pawel P., Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Zadeh, Gelareh, Faury, Damien, Pfister, Stefan M., Jabado, Nada, Majewski, Jacek

“…Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To…”
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Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations by Magnus, Nathalie, Garnier, Delphine, Meehan, Brian, McGraw, Serge, Lee, Tae Hoon, Caron, Maxime, Bourque, Guillaume, Milsom, Chloe, Jabado, Nada, Trasler, Jacquetta, Pawlinski, Rafal, Mackman, Nigel, Rak, Janusz

“…The coagulation system links immediate (hemostatic) and late (inflammatory, angiogenic) tissue responses to injury, a continuum that often is subverted in…”
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Epidemiology of Pediatric Tumors in Quebec: A 17-Year Report of Cancer in Young People in the Canada Registry by Bellavance, Caroline, Lalonde, Benoit, Simonyan, David, Jabado, Nada, Perreault, Sebastien, Larouche, Valérie

“…Cancer is the leading cause of disease-related death among children of more than 1 year of age. However, childhood cancer risk factors and etiology are yet to…”
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TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw by Gomes, Carolina Cavalieri, Gayden, Tenzin, Bajic, Andrea, Harraz, Osama F., Pratt, Jonathan, Nikbakht, Hamid, Bareke, Eric, Diniz, Marina Gonçalves, Castro, Wagner Henriques, St-Onge, Pascal, Sinnett, Daniel, Han, HyeRim, Rivera, Barbara, Mikael, Leonie G., De Jay, Nicolas, Kleinman, Claudia L., Valera, Elvis Terci, Bassenden, Angelia V., Berghuis, Albert M., Majewski, Jacek, Nelson, Mark T., Gomez, Ricardo Santiago, Jabado, Nada

“…Giant cell lesions of the jaw (GCLJ) are debilitating tumors of unknown origin with limited available therapies. Here, we analyze 58 sporadic samples using…”
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CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation by Martin, Emmanuel, Palmic, Noé, Sanquer, Sylvia, Lenoir, Christelle, Hauck, Fabian, Mongellaz, Cédric, Fabrega, Sylvie, Nitschké, Patrick, Esposti, Mauro Degli, Schwartzentruber, Jeremy, Taylor, Naomi, Majewski, Jacek, Jabado, Nada, Wynn, Robert F., Picard, Capucine, Fischer, Alain, Arkwright, Peter D., Latour, Sylvain

“…Loss-of-function mutations in the human CTP synthase 1 gene cause an immunodeficiency disease with impaired T cell proliferation after antigen stimulation,…”
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Phenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model by Ismail, Joy N., Mantash, Sarah, Hallal, Mohammad, Jabado, Nada, Khoueiry, Pierre, Shirinian, Margret

“…Ten-Eleven Translocation (TET) proteins have recently come to light as important epigenetic regulators conserved in multicellular organisms. TET knockdown…”
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