Search Results - "Jabůrek, Martin"

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling by Ježek, Petr, Holendová, Blanka, Garlid, Keith D, Jabůrek, Martin

“…Mitochondria are the energetic, metabolic, redox, and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics, and…”
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Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity by Ježek, Petr, Jabůrek, Martin, Holendová, Blanka, Plecitá-Hlavatá, Lydie

“…Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress,…”
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Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1) by Ježek, Petr, Jabůrek, Martin, Porter, Richard K.

“…Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering…”
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Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality by Chiang, Ason C. Y., Ježek, Jan, Mu, Peiqiang, Di, Ying, Klucnika, Anna, Jabůrek, Martin, Ježek, Petr, Ma, Hansong

“…Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between…”
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Contribution of Mitochondria to Insulin Secretion by Various Secretagogues by Ježek, Petr, Holendová, Blanka, Jabůrek, Martin, Dlasková, Andrea, Plecitá-Hlavatá, Lydie

“…Mitochondria determine glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells by elevating ATP synthesis. As the metabolic and redox hub,…”
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Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4 by Plecitá-Hlavatá, Lydie, Jabůrek, Martin, Holendová, Blanka, Tauber, Jan, Pavluch, Vojtěch, Berková, Zuzana, Cahová, Monika, Schröder, Katrin, Brandes, Ralf P., Siemen, Detlef, Ježek, Petr

“…NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase…”
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H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells by Ježek, Jan, Dlasková, Andrea, Zelenka, Jaroslav, Jabůrek, Martin, Ježek, Petr

“…Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since…”
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Mitochondria to plasma membrane redox signaling is essential for fatty acid β-oxidation-driven insulin secretion by Jabůrek, Martin, Klöppel, Eduardo, Průchová, Pavla, Mozheitova, Oleksandra, Tauber, Jan, Engstová, Hana, Ježek, Petr

“…We asked whether acute redox signaling from mitochondria exists concomitantly to fatty acid- (FA-) stimulated insulin secretion (FASIS) at low glucose by…”
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Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid-Conducting SLC25 Gene Family Transporters by Jabůrek, Martin, Průchová, Pavla, Holendová, Blanka, Galkin, Alexander, Ježek, Petr

“…Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca -independent phospholipase A2γ (iPLA2γ), is addressed to the mitochondrial matrix…”
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The Pancreatic β-Cell: The Perfect Redox System by Ježek, Petr, Holendová, Blanka, Jabůrek, Martin, Tauber, Jan, Dlasková, Andrea, Plecitá-Hlavatá, Lydie

“…Pancreatic β-cell insulin secretion, which responds to various secretagogues and hormonal regulations, is reviewed here, emphasizing the fundamental redox…”
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Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen by Jabůrek, Martin, Ježek, Jan, Zelenka, Jaroslav, Ježek, Petr

“…Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of…”
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Mitochondrial Physiology of Cellular Redox Regulations by Ježek, P, Dlasková, A, Engstová, H, Špačková, J, Tauber, J, Průchová, P, Kloppel, E, Mozheitova, O, Jabůrek, M

“…Mitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling,…”
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Mitochondrial PKCε and Mitochondrial ATP-Sensitive K+ Channel Copurify and Coreconstitute to Form a Functioning Signaling Module in Proteoliposomes by Jabůrek, Martin, Costa, Alexandre D.T, Burton, Jana R, Costa, Cinthia L, Garlid, Keith D

“…Mitochondria are key mediators of the cardioprotective signal and the mitochondrial ATP-sensitive K channel (mitoKATP) plays a crucial role in originating and…”
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Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress by Alán, Lukáš, Špaček, Tomáš, Pajuelo Reguera, David, Jabůrek, Martin, Ježek, Petr

“…Mitochondrial DNA (mtDNA) is compacted in ribonucleoprotein complexes called nucleoids, which can divide or move within the mitochondrial network…”
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Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10 by Jaburek, Martin, Garlid, Keith D

“…The successful development of recombinant expression and reconstitution protocols has enabled a detailed study of the transport properties and regulation of…”
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Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells by Tauber, Jan, Dlasková, Andrea, Šantorová, Jitka, Smolková, Katarína, Alán, Lukáš, Špaček, Tomáš, Plecitá-Hlavatá, Lydie, Jabůrek, Martin, Ježek, Petr

“…Mitochondrial DNA (mtDNA) is organized in nucleoids in complex with accessory proteins, proteins of mtDNA replication and gene expression machinery. A robust…”
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Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers by Beck, Valeri, Jaburek, Martin, Demina, Tatiana, Rupprecht, Anne, Porter, Richard K., Jezek, Petr, Pohl, Elena E.

“…ABSTRACT Uncoupling proteins 1 (UCP1) and 2 (UCP2) belong to the family of mitochondrial anion transporters and share 59% sequence identity with each other…”
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Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen by Jabůrek, Martin, Ježek, Jan, Ježek, Petr

“…Mitochondrial uncoupling protein‐2 (UCP2) mediates free fatty acid (FA)‐dependent H+ translocation across the inner mitochondrial membrane (IMM), which leads…”
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Import of desired nucleic acid sequences using addressing motif of mitochondrial ribosomal 5S-rRNA for fluorescent in vivo hybridization of mitochondrial DNA and RNA by Zelenka, Jaroslav, Alán, Lukáš, Jabůrek, Martin, Ježek, Petr

“…Based on the matrix-addressing sequence of mitochondrial ribosomal 5S-rRNA (termed MAM), which is naturally imported into mitochondria, we have constructed an…”
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Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca2+-Independent Phospholipase A2γ in the Brain by Průchová, Pavla, Gotvaldová, Klára, Smolková, Katarína, Alán, Lukáš, Holendová, Blanka, Tauber, Jan, Galkin, Alexander, Ježek, Petr, Jabůrek, Martin

“…Mitochondrial Ca2+-independent phospholipase A2γ (iPLA2γ/PNPLA8) was previously shown to be directly activated by H2O2 and release free fatty acids (FAs) for…”
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