Search Results - "Jaakkola, Panu M."

The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3 by Jaakkola, Panu M, Rantanen, Krista

“…The prolyl 4-hydroxylase domain protein 3 (PHD3) belongs to 2-oxoglutarate and iron-dependent dioxygenases. Together with the two closest paralogues, PHD1 and…”
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A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma by Mattila, Kalle E., Laajala, Teemu D., Tornberg, Sara V., Kilpeläinen, Tuomas P., Vainio, Paula, Ettala, Otto, Boström, Peter J., Nisen, Harry, Elo, Laura L., Jaakkola, Panu M.

“…After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic…”
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Transportable system enabling multiple irradiation studies under simultaneous hypoxia in vitro by Metsälä, Olli, Kreutzer, Joose, Högel, Heidi, Miikkulainen, Petra, Kallio, Pasi, Jaakkola, Panu M

“…Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been…”
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Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma by Khan, Misba, Islam, Md. Khirul, Rahman, Mafiur, Dhondt, Bert, Quintero, Ileana, Puhka, Maija, Jaakkola, Panu M., Lamminmäki, Urpo, Leivo, Janne

“…Half of patients with renal cell carcinoma (RCC) develop metastases. New and noninvasive biomarkers are needed for the diagnosis of RCC. The study aims to…”
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Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells by Högel, Heidi, Rantanen, Krista, Jokilehto, Terhi, Grenman, Reidar, Jaakkola, Panu M

“…Hypoxia restricts cell proliferation and cell cycle progression at the G1/S interface but at least a subpopulation of carcinoma cells can escape the…”
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p62 degradation by autophagy: Another way for cancer cells to survive under hypoxia by Jaakkola, Panu M., Pursiheimo, Juha-Pekka

“…Hypoxia is a common feature of advanced solid tumors causing cancer progression and resistance to treatment. Hypoxia activates mitophagy as well as…”
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Hypoxia-activated Smad3-specific Dephosphorylation by PP2A by Heikkinen, Pekka T, Nummela, Marika, Leivonen, Suvi-Katri, Westermarck, Jukka, Hill, Caroline S, Kähäri, Veli-Matti, Jaakkola, Panu M

“…The transforming growth factor-β (TGF-β) maintains epithelial homeostasis and suppresses early tumor formation, but paradoxically at later stages of tumor…”
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Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation by Rantanen, Krista, Pursiheimo, Juha, Högel, Heidi, Himanen, Virpi, Metzen, Eric, Jaakkola, Panu M

“…The HIF prolyl hydroxylases (PHDs/EGLNs) are central regulators of the molecular responses to oxygen availability. One isoform, PHD3, is expressed in response…”
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HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma by Miikkulainen, Petra, Högel, Heidi, Rantanen, Krista, Suomi, Tomi, Kouvonen, Petri, Elo, Laura L, Jaakkola, Panu M

“…A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the…”
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Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness by JOKILEHTO, Terhi, RANTANEN, Krista, LUUKKAA, Marjaana, HEIKKINEN, Pekka, GRENMAN, Reidar, MINN, Heikki, KRONQVIST, Pauliina, JAAKKOLA, Panu M

“…PURPOSE: Hypoxia in tumors is associated with poor prognosis and resistance to treatment. The outcome of hypoxia is largely regulated by the hypoxia-inducible…”
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Prognostic Factors for Localized Clear Cell Renal Cell Carcinoma and Their Application in Adjuvant Therapy by Mattila, Kalle E, Vainio, Paula, Jaakkola, Panu M

“…Approximately 20% of patients with renal cell carcinoma (RCC) present with primarily metastatic disease and over 30% of patients with localized RCC will…”
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The role of HIF prolyl hydroxylases in tumour growth by Jokilehto, Terhi, Jaakkola, Panu M.

“…•  Hypoxia in tumours •  Overview of the oxygen‐sensing mechanisms •  The family of HIF hydroxylases •  Expression of PHDs in normal tissues •  Regulation of…”
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Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma by Miikkulainen, Petra, Högel, Heidi, Seyednasrollah, Fatemeh, Rantanen, Krista, Elo, Laura L., Jaakkola, Panu M.

“…Most clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel–Lindau tumor suppressor protein (pVHL), resulting in the accumulation of…”
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Survival of patients with ruptured gastrointestinal stromal tumour treated with adjuvant imatinib in a randomised trial by Joensuu, Heikki, Reichardt, Annette, Eriksson, Mikael, Hohenberger, Peter, Boye, Kjetil, Cameron, Silke, Lindner, Lars H., Jost, Philipp J., Bauer, Sebastian, Schütte, Jochen, Lindskog, Stefan, Kallio, Raija, Jaakkola, Panu M., Goplen, Dorota, Wardelmann, Eva, Reichardt, Peter

“…Background Patients with ruptured gastrointestinal stromal tumour (GIST) have poor prognosis. Little information is available about how adjuvant imatinib…”
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Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27 by Högel, Heidi, Miikkulainen, Petra, Bino, Lucia, Jaakkola, Panu M

“…Hypoxia can halt cell cycle progression of several cell types at the G1/S interface. The arrest needs to be overcome by cancer cells. We have previously shown…”
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Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling by Paatero, Ilkka, Jokilammi, Anne, Heikkinen, Pekka T., Iljin, Kristiina, Kallioniemi, Olli-Pekka, Jones, Frank E., Jaakkola, Panu M., Elenius, Klaus

“…The receptor-tyrosine kinase ErbB4 was identified as a direct regulator of hypoxia-inducible factor-1α (HIF-1α) signaling. Cleaved intracellular domain of…”
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p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation by Rantanen, Krista, Pursiheimo, Juha-Pekka, Högel, Heidi, Miikkulainen, Petra, Sundström, Jari, Jaakkola, Panu M

“…The hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 regulates cellular responses to hypoxia. In normoxia the expression of PHD3 is low and it occurs in…”
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Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion by HEIKKINEN, Pekka T, NUMMELA, Marika, JOKILEHTO, Terhi, GRENMAN, Reidar, KÄHÄRI, Veli-Matti, JAAKKOLA, Panu M

“…Smad7 is an inhibitor of the transforming growth factor-beta-activated signaling pathway. Under well-oxygenated conditions, Smad7 is a potent inhibitor of…”
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Intra- and extracellular signaling by endothelial neuregulin-1 by Iivanainen, Erika, Paatero, Ilkka, Heikkinen, Satu-Maria, Junttila, Teemu T., Cao, Renhai, Klint, Peter, Jaakkola, Panu M., Cao, Yihai, Elenius, Klaus

“…Suppression of tumor growth by inhibition of ErbB receptor signaling is well documented. However, relatively little is known about the ErbB signaling system in…”
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Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth by Jokilehto, Terhi, Högel, Heidi, Heikkinen, Pekka, Rantanen, Krista, Elenius, Klaus, Sundström, Jari, Jaakkola, Panu M.

“…Cellular oxygen tension is sensed by a family of prolyl hydroxylases (PHD1-3) that regulate the degradation of hypoxia-inducible factors (HIF-1α and -2α). The…”
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