Search Results - "Jäger, Walter"

Future Aspects for Cannabinoids in Breast Cancer Therapy by Kisková, Terézia, Mungenast, Felicitas, Suváková, Mária, Jäger, Walter, Thalhammer, Theresia

“…Cannabinoids (CBs) from provide relief for tumor-associated symptoms (including nausea, anorexia, and neuropathic pain) in the palliative treatment of cancer…”
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Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal Supplements by Stieger, Bruno, Mahdi, Zainab M, Jäger, Walter

“…Herbal supplements are generally considered safe; however, drug disposition is influenced by the interactions of herbal supplements and food constituents with…”
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Chemopreventive effects of resveratrol and resveratrol derivatives by Szekeres, Thomas, Saiko, Philipp, Fritzer-Szekeres, Monika, Djavan, Bob, Jäger, Walter

“…Resveratrol is considered to have a number of beneficial effects. Recently, our group modified the molecule and synthesized a number of compounds with…”
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Identification of Novel Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3 (OATP1B1 and OATP1B3) Using a Consensus Vote of Six Classification Models by Kotsampasakou, Eleni, Brenner, Stefan, Jäger, Walter, Ecker, Gerhard F

“…Organic anion transporting polypeptides 1B1 and 1B3 are transporters selectively expressed on the basolateral membrane of the hepatocyte. Several studies…”
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Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study by Bauer, Martin, Karch, Rudolf, Zeitlinger, Markus, Philippe, Cécile, Römermann, Kerstin, Stanek, Johann, Maier-Salamon, Alexandra, Wadsak, Wolfgang, Jäger, Walter, Hacker, Marcus, Müller, Markus, Langer, Oliver

“…As P-glycoprotein (Pgp) inhibition at the blood–brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron…”
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Meropenem concentrations in brain tissue of neurointensive care patients exceed CSF levels by Hosmann, Arthur, Ritscher, Lavinia, Burgmann, Heinz, Al Jalali, Valentin, Wulkersdorfer, Beatrix, Wölfl-Duchek, Michael, Sanz Codina, Maria, Jäger, Walter, Poschner, Stefan, Plöchl, Walter, Reinprecht, Andrea, Rössler, Karl, Gruber, Andreas, Zeitlinger, Markus

“…Abstract Background Inadequate antibiotic exposure in cerebral infections might have detrimental effects on clinical outcome. Commonly, antibiotic…”
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Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer by Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Heilos, Daniela, Gabler, Lisa, van Schoonhoven, Sushilla, Terenzi, Alessio, Moser, Patrick, Pirker, Christine, Timelthaler, Gerald, Jäger, Walter, Kowol, Christian R, Heffeter, Petra, Grusch, Michael, Berger, Walter

“…Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It…”
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Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice by Bauer, Martin, Traxl, Alexander, Matsuda, Akihiro, Karch, Rudolf, Philippe, Cécile, Nics, Lukas, Klebermass, Eva-Maria, Wulkersdorfer, Beatrix, Weber, Maria, Poschner, Stefan, Tournier, Nicolas, Jäger, Walter, Wadsak, Wolfgang, Hacker, Marcus, Wanek, Thomas, Zeitlinger, Markus, Langer, Oliver

“…Organic anion-transporting polypeptides (OATPs) mediate the uptake of various drugs from blood into the liver in the basolateral membrane of hepatocytes…”
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Microdosing as a Potential Tool to Enhance Clinical Development of Novel Antibiotics: A Tissue and Plasma PK Feasibility Study with Ciprofloxacin by Oesterreicher, Zoe, Eberl, Sabine, Wulkersdorfer, Beatrix, Matzneller, Peter, Eder, Claudia, van Duijn, Esther, Vaes, Wouter H. J., Reiter, Birgit, Stimpfl, Thomas, Jäger, Walter, Nussbaumer-Proell, Alina, Marhofer, Daniela, Marhofer, Peter, Langer, Oliver, Zeitlinger, Markus

“…Background and Objective In microdose studies, drug pharmacokinetics is measured in humans after administration of subtherapeutic doses. While previous…”
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Inhibition of ABCB1 and ABCG2 at the Mouse Blood–Brain Barrier with Marketed Drugs To Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]erlotinib by Traxl, Alexander, Mairinger, Severin, Filip, Thomas, Sauberer, Michael, Stanek, Johann, Poschner, Stefan, Jäger, Walter, Zoufal, Viktoria, Novarino, Gaia, Tournier, Nicolas, Bauer, Martin, Wanek, Thomas, Langer, Oliver

“…P-Glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters at the blood–brain barrier (BBB), which effectively restrict…”
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Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro by Holzner, Silvio, Senfter, Daniel, Stadler, Serena, Staribacher, Anna, Nguyen, Chi Huu, Gaggl, Anna, Geleff, Silvana, Huttary, Nicole, Krieger, Sigurd, Jäger, Walter, Dolznig, Helmut, Mader, Robert M, Krupitza, Georg

“…Since cancer cells, when grown as spheroids, display drug sensitivity and radiation resistance patterns such as seen in vivo we recently established a…”
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Identification of a Synthetic Polyhydroxyphenolic Resveratrol Analogue, 3,3',4,4',5,5'-Hexahydroxy- trans -Stilbene with Anti-SARS-CoV-2 Activity by Jäger, Walter, Kicker, Eva, Hardt, Melina, Gawish, Riem, Gattinger, Pia, Böhmdorfer, Michaela, Knapp, Sylvia, Valenta, Rudolf, Zatloukal, Kurt, Szekeres, Thomas

“…The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has been causing the COVID-19 pandemic since December 2019, with over 600 million…”
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A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier by Bauer, Martin, Karch, Rudolf, Wulkersdorfer, Beatrix, Philippe, Cécile, Nics, Lukas, Klebermass, Eva-Maria, Weber, Maria, Poschner, Stefan, Haslacher, Helmuth, Jäger, Walter, Tournier, Nicolas, Wadsak, Wolfgang, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver

“…The adenosine triphosphate-binding cassette transporters P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are 2 efflux transporters at the…”
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The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach by Poschner, Stefan, Maier-Salamon, Alexandra, Zehl, Martin, Wackerlig, Judith, Dobusch, Daniel, Pachmann, Bettina, Sterlini, Konstantin L, Jäger, Walter

“…The beneficial effect of dietary soy food intake, especially for women diagnosed with breast cancer, is controversial, as data has shown that the soy…”
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Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects by Bauer, Martin, Wulkersdorfer, Beatrix, Karch, Rudolf, Philippe, Cécile, Jäger, Walter, Stanek, Johann, Wadsak, Wolfgang, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver

“…Aims The efflux transporter P‐glycoprotein (ABCB1) acts at the blood–brain barrier (BBB) to restrict the distribution of many different drugs from blood to the…”
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Measurement of Hepatic ABCB1 and ABCG2 Transport Activity with [11C]Tariquidar and PET in Humans and Mice by Hernández Lozano, Irene, Bauer, Martin, Wulkersdorfer, Beatrix, Traxl, Alexander, Philippe, Cécile, Weber, Maria, Häusler, Stephanie, Stieger, Bruno, Jäger, Walter, Mairinger, Severin, Wanek, Thomas, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver

“…P-Glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) in the canalicular membrane of hepatocytes mediate the biliary excretion of drugs and drug…”
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Altered Profile of E1-S Transporters in Endometrial Cancer: Lower Protein Levels of ABCG2 and OSTβ and Up-Regulation of SLCO1B3 Expression by Pavlič, Renata, Vidic, Suzana, Anko, Maja, Knific, Tamara, Büdefeld, Tomaž, Marton, Kristina, Sinreih, Maša, Poschner, Stefan, Jäger, Walter, Frković-Grazio, Snježana, Rižner, Tea Lanišnik

“…Endometrial cancer (EC) is associated with increased estrogen actions. Locally, estrogens can be formed from estrone-sulphate (E1-S) after cellular uptake by…”
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Impact of thrombocytes, on bacterial growth and antimicrobial activity of selected antibiotics by Nussbaumer-Pröll, Alina Karoline, Eberl, Sabine, Reiter, Birgit, Stimpfl, Thomas, Jäger, Walter, Poschner, Stefan, Zeitlinger, Markus

“…In vitro pharmacodynamic models are used to optimize in vivo dosing regimens in antimicrobial drug development. One limiting factor of such models is the lack…”
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Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice by Böhmdorfer, Michaela, Szakmary, Akos, Schiestl, Robert H, Vaquero, Javier, Riha, Juliane, Brenner, Stefan, Thalhammer, Theresia, Szekeres, Thomas, Jäger, Walter

“…Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing…”
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Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro by Holzner, Silvio, Brenner, Stefan, Atanasov, Atanas Georgiev, Senfter, Daniel, Stadler, Serena, Nguyen, Chi Huu, Fristiohady, Adryan, Milovanovic, Daniela, Huttary, Nicole, Krieger, Sigurd, Bago-Horvath, Zsuzsanna, de Wever, Oliver, Tentes, Ioannis, Özmen, Ali, Jäger, Walter, Dolznig, Helmut, Dirsch, Verena Maria, Mader, Robert Michael, Krenn, Liselotte, Krupitza, Georg

“…Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell…”
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