Search Results - "Ja, William W"

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality by Clark, Rebecca I., Salazar, Anna, Yamada, Ryuichi, Fitz-Gibbon, Sorel, Morselli, Marco, Alcaraz, Jeanette, Rana, Anil, Rera, Michael, Pellegrini, Matteo, Ja, William W., Walker, David W.

“…Alterations in the composition of the intestinal microbiota have been correlated with aging and measures of frailty in the elderly. However, the relationships…”
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Circadian autophagy drives iTRF-mediated longevity by Ulgherait, Matt, Midoun, Adil M., Park, Scarlet J., Gatto, Jared A., Tener, Samantha J., Siewert, Julia, Klickstein, Naomi, Canman, Julie C., Ja, William W., Shirasu-Hiza, Mimi

“…Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing treatment for organisms from  Drosophila  to humans 1 – 5 . TRF restricts…”
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Drosophila as a model for the gut microbiome by Ludington, William B, Ja, William W

“…In particular, Drosophila melanogaster, the fruit fly, is one of the most powerful models for animal genetics and has a simple microbiome composed of 5 to 20…”
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Probabilistic Invasion Underlies Natural Gut Microbiome Stability by Obadia, Benjamin, Güvener, Z.T., Zhang, Vivian, Ceja-Navarro, Javier A., Brodie, Eoin L., Ja, William W., Ludington, William B.

“…Species compositions of gut microbiomes impact host health [1–3], but the processes determining these compositions are largely unknown. An unexplained…”
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Microbes Promote Amino Acid Harvest to Rescue Undernutrition in Drosophila by Yamada, Ryuichi, Deshpande, Sonali A., Bruce, Kimberley D., Mak, Elizabeth M., Ja, William W.

“…Microbes play an important role in the pathogenesis of nutritional disorders such as protein-specific malnutrition. However, the precise contribution of…”
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Quantifying Drosophila food intake: comparative analysis of current methodology by Deshpande, Sonali A, Carvalho, Gil B, Amador, Ariadna, Phillips, Angela M, Hoxha, Sany, Lizotte, Keith J, Ja, William W

“…This Analysis compares four commonly used assays to measure food intake in flies and identifies radioisotope-labeling and the capillary feeder (CAFE) as the…”
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translin Is Required for Metabolic Regulation of Sleep by Murakami, Kazuma, Yurgel, Maria E., Stahl, Bethany A., Masek, Pavel, Mehta, Aradhana, Heidker, Rebecca, Bollinger, Wesley, Gingras, Robert M., Kim, Young-Joon, Ja, William W., Suter, Beat, DiAngelo, Justin R., Keene, Alex C.

“…Dysregulation of sleep or feeding has enormous health consequences. In humans, acute sleep loss is associated with increased appetite and insulin…”
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The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage by Banerjee, Surya, Woods, Christine, Burnett, Micheal, Park, Scarlet J., Ja, William W., Curtiss, Jennifer

“…The prototypical M13 peptidase, human Neprilysin, functions as a transmembrane “ectoenzyme” that cleaves neuropeptides that regulate e.g. glucose metabolism,…”
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Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila by Chen, Yu-Chieh David, Park, Scarlet Jinhong, Joseph, Ryan Matthew, Ja, William W., Dahanukar, Anupama Arun

“…Taste drives appropriate food preference and intake. In Drosophila, taste neurons are housed in both external and internal organs, but the latter have been…”
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Prandiology of Drosophila and the CAFE Assay by Ja, William W., Carvalho, Gil B., Mak, Elizabeth M., de la Rosa, Noelle N., Fang, Annie Y., Liong, Jonathan C., Brummel, Ted, Benzer, Seymour

“…Studies of feeding behavior in genetically tractable invertebrate model systems have been limited by the lack of proper methodology. We introduce the Capillary…”
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The Nutritional Environment Influences the Impact of Microbes on Drosophila melanogaster Life Span by Keebaugh, Erin S, Yamada, Ryuichi, Ja, William W

“…Microbes can extend life span by contributing to the nutritional value of malnourishing fly culture medium. The beneficial effect of microbes during…”
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Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila by Botero, Valentina, Stanhope, Bethany A., Brown, Elizabeth B., Grenci, Eliza C., Boto, Tamara, Park, Scarlet J., King, Lanikea B., Murphy, Keith R., Colodner, Kenneth J., Walker, James A., Keene, Alex C., Ja, William W., Tomchik, Seth M.

“…Neurofibromatosis type 1 is a chronic multisystemic genetic disorder that results from loss of function in the neurofibromin protein. Neurofibromin may…”
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Microbial Quantity Impacts Drosophila Nutrition, Development, and Lifespan by Keebaugh, Erin S., Yamada, Ryuichi, Obadia, Benjamin, Ludington, William B., Ja, William W.

“…In Drosophila, microbial association can promote development or extend life. We tested the impact of microbial association during malnutrition and show that…”
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A Molecular Target for an Alcohol Chain-Length Cutoff by Chung, Hae-Won, Petersen, E. Nicholas, Cabanos, Cerrone, Murphy, Keith R., Pavel, Mahmud Arif, Hansen, Andrew S., Ja, William W., Hansen, Scott B.

“…Despite the widespread consumption of ethanol, mechanisms underlying its anesthetic effects remain uncertain. n-Alcohols induce anesthesia up to a specific…”
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Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder by Tener, Samantha J., Lin, Zhi, Park, Scarlet J., Oraedu, Kairaluchi, Ulgherait, Matthew, Van Beek, Emily, Martínez-Muñiz, Andrés, Pantalia, Meghan, Gatto, Jared A., Volpi, Julia, Stavropoulos, Nicholas, Ja, William W., Canman, Julie C., Shirasu-Hiza, Mimi

“…Mutations in Cullin-3 ( Cul3 ), a conserved gene encoding a ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we…”
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Author Correction: The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage by Banerjee, Surya, Woods, Christine, Burnett, Micheal, Park, Scarlet J., Ja, William W., Curtiss, Jennifer

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Postprandial sleep mechanics in Drosophila by Murphy, Keith R, Deshpande, Sonali A, Yurgel, Maria E, Quinn, James P, Weissbach, Jennifer L, Keene, Alex C, Dawson-Scully, Ken, Huber, Robert, Tomchik, Seth M, Ja, William W

“…Food consumption is thought to induce sleepiness. However, little is known about how postprandial sleep is regulated. Here, we simultaneously measured sleep…”
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Excreta Quantification (EX-Q) for Longitudinal Measurements of Food Intake in Drosophila by Wu, Qi, Yu, Guixiang, Park, Scarlet J., Gao, Yue, Ja, William W., Yang, Mingyao

“…Longitudinal measurements of food intake remain a challenge in Drosophila studies of nutrition and behavior. Here, we report an improved method for measuring…”
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In vivo expression of peptidylarginine deiminase in Drosophila melanogaster by Mahneva, Olena, Risley, Monica G, John, Ciny, Milton, Sarah L, Dawson-Scully, Ken, Ja, William W

“…Peptidylarginine deiminase (PAD) modifies peptidylarginine and converts it to peptidylcitrulline in the presence of elevated calcium. Protein modification can…”
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PGC1α Controls Sucrose Taste Sensitization in Drosophila by Wang, Qiao-Ping, Lin, Yong Qi, Lai, Mei-Ling, Su, Zhiduan, Oyston, Lisa J., Clark, Teleri, Park, Scarlet J., Khuong, Thang M., Lau, Man-Tat, Shenton, Victoria, Shi, Yan-Chuan, James, David E., Ja, William W., Herzog, Herbert, Simpson, Stephen J., Neely, G. Gregory

“…Perceived palatability of food controls caloric intake. Sweet taste is the primary means of detecting the carbohydrate content of food. Surprisingly, sweet…”
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