Search Results - "JUSKO, William J"

Assessing Liver-to-Plasma Partition Coefficients and In Silico Calculation Methods: When Does the Hepatic Model Matter in PBPK? by Li, Xiaonan, Jusko, William J

“…The primary models used in pharmacokinetics (PK) to assess hepatic clearance ( ) are the well-stirred (WSM), parallel tube (PTM), and dispersion model (DM)…”
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Physiologically Based Pharmacokinetics of Lysosomotropic Chloroquine in Rat and Human by Liu, Xin, Jusko, William J

“…A semimechanistic physiologically based pharmacokinetic (PBPK) model for chloroquine (CQ), a highly lysosomotropic weak base, was applied to digitized rat and…”
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Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model by Zhao, Jie, Cao, Yanguang, Jusko, William J.

“…ABSTRACT Purpose To examine the across-species scalability of monoclonal antibody (mAb) pharmacokinetics (PK) and assess similarities in tissue distribution…”
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Anti-inflammatory effects of dexamethasone in COVID-19 patients: Translational population PK/PD modeling and simulation by Świerczek, Artur, Jusko, William J

“…Dexamethasone (DEX) given at a dose of 6 mg once-daily for 10 days is a recommended dosing regimen in patients with coronavirus disease 2019 (COVID-19)…”
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Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species by Jeong, Yoo-Seong, Jusko, William J

“…The objective of this study was to systematically assess literature datasets and quantitatively analyze metformin PK in plasma and some tissues of nine…”
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Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies by Cao, Yanguang, Jusko, William J.

“…Target-mediated drug disposition (TMDD) usually accounts for nonlinear pharmacokinetics (PK) of drugs whose distribution and/or clearance are affected by their…”
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Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies by Cao, Yanguang, Balthasar, Joseph P., Jusko, William J.

“…Minimal physiologically-based pharmacokinetic (mPBPK) models provide a sensible modeling approach when fitting only plasma (or blood) data yielding…”
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Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India by Jobe, Alan H., Milad, Mark A., Peppard, Thomas, Jusko, William J.

“…High‐dose betamethasone and dexamethasone are standard of care treatments for women at risk of preterm delivery to improve neonatal respiratory and mortality…”
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Daily variation of gene expression in diverse rat tissues by Mavroudis, Panteleimon D, DuBois, Debra C, Almon, Richard R, Jusko, William J

“…Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate…”
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Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans by Gao, Wei, Jusko, William J

“…A mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model was developed for exendin-4 to account for receptor-mediated endocytosis via glucagon-like…”
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Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action by Sukumaran, Siddharth, Almon, Richard R., DuBois, Debra C., Jusko, William J.

“…Circadian rhythms (24 h cycles) are observed in virtually all aspects of mammalian function from expression of genes to complex physiological processes. The…”
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Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model by Cao, Yanguang, Jusko, William J.

“…Minimal physiologically based pharmacokinetic (mPBPK) models provide a simple and sensible approach that incorporates physiological elements into…”
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Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats by Gao, Wei, Jusko, William J

“…The pharmacokinetics (PK) and pharmacodynamics (PD) of exendin-4 were studied in type 2 diabetic Goto-Kakizaki rats after single doses at 0.5, 1, 5, or 10…”
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Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat by Mavroudis, Panteleimon D, DuBois, Debra C, Almon, Richard R, Jusko, William J

“…Circadian clocks, present in almost all cells of the body, are entrained to rhythmic changes in the environment (e.g. light/dark cycles). Genes responsible for…”
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Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells by Hamed, Salaheldin S., Straubinger, Robert M., Jusko, William J.

“…Purpose The standard of care for treating patients with pancreatic adenocarcinomas includes gemcitabine (2′,2′-difluorodeoxycytidine). Gemcitabine primarily…”
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Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats by Chen, Xiaodi, Song, Dawei, Nakada, Sakura, Qiu, Joseph, Iwamoto, Karin, Chen, Ray H, Lim, Yow-Pin, Jusko, William J, Stonestreet, Barbara S

“…Hypoxic-ischemic (HI) brain injury is a leading cause of long-term neurodevelopmental morbidities in neonates. Human plasma-derived Inter-Alpha Inhibitor…”
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Minimal physiologically‐based hybrid model of pharmacokinetics in pregnant women: Application to antenatal corticosteroids by Krzyzanski, Wojciech, Milad, Mark A., Jobe, Alan H., Jusko, William J.

“…Minimal physiologically‐based pharmacokinetic (mPBPK) models are an alternative to full physiologically‐based pharmacokinetic (PBPK) models as they offer…”
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Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans by Mager, Donald E., Woo, Sukyung, Jusko, William J.

“…An important feature of mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) models is the identification of drug- and system-specific factors that…”
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Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest by Vali, Payam, Chandrasekharan, Praveen, Rawat, Munmun, Gugino, Sylvia, Koenigsknecht, Carmon, Helman, Justin, Jusko, William J., Mathew, Bobby, Berkelhamer, Sara, Nair, Jayasree, Wyckoff, Myra H., Lakshminrusimha, Satyan

“…Background Epinephrine administered by low umbilical venous catheter (UVC) or endotracheal tube (ETT) is indicated in neonates who fail to respond to positive…”
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Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action by Sukumaran, Siddharth, Jusko, William J, Dubois, Debra C, Almon, Richard R

“…Diurnal-nocturnal, or circadian-like, rhythms are 24-h variations in biological processes, evolved for the efficient functioning of living organisms. Such…”
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