Altered distribution of urinary glycosaminoglycans in diabetic subjects

Altered distribution of urinary glycosaminoglycans in diabetic subjects

We studied the influence of type 1 and type 2 diabetes mellitus with similar duration on the urinary excretion of total glycosaminoglycans and alteration of urinary glycosaminoglycan distribution pattern. Investigations were performed in the 24-hour urine samples of 31 children with type 1 diabetes...

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Bibliographic Details
Published in:Acta diabetologica Vol. 39; no. 3; pp. 123 - 128
Main Authors: JURETI, D, KRAJNOVIC, V, LUKAC-BAJALO, J
Format: Journal Article
Language:English
Published: Berlin Springer International 01-09-2002
Springer Nature B.V
Subjects:
Adolescent
Adult
Age of Onset
Aged
Albuminuria
Associated diseases and complications
Biological and medical sciences
Blood Glucose - metabolism
Blood Pressure
Child
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - urine
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - urine
Diabetes. Impaired glucose tolerance
Diet, Diabetic
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Glycated Hemoglobin A - analysis
Glycosaminoglycans - urine
Humans
Hypoglycemic Agents - therapeutic use
Male
Medical sciences
Middle Aged
Reference Values
Endocrinopathy
Human
Kidney disease
Proteoglycan
Urine
Immunopathology
Biological fluid
Urinary system disease
Pathogenesis
Diabetes mellitus
Albumin
Autoimmune disease
Non insulin dependent diabetes
Nephropathy
Insulin dependent diabetes
Adult
Complication
Glycosaminoglycan
Child
Microalbuminuria
Proteinuria
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Summary:We studied the influence of type 1 and type 2 diabetes mellitus with similar duration on the urinary excretion of total glycosaminoglycans and alteration of urinary glycosaminoglycan distribution pattern. Investigations were performed in the 24-hour urine samples of 31 children with type 1 diabetes mellitus, 36 adults with type 2 diabetes mellitus and in 30 age-matched controls for each group. We found that type 2 diabetes mellitus also induced an increased urinary excretion of total glycosaminoglycans and that both type 1 and type 2 diabetes alter the urinary distribution of heparan sulphate and dermatan sulphate. Observed changes correlate with duration of the disease. Microalbuminuria was detected in 9 of 36 type 2 adult diabetics (25%). The microalbuminic group had a significantly higher heparan sulphate and/or dermatan sulphate excretion rate. To clarify whether an altered urinary distribution of heparan sulphate and dermatan sulphate may precede the development of microalbuminuria, it is necessary to performed a prospective study in which urinary glycosaminoglycans and microalbuminuria are measured year by year starting from the diagnosis of diabetes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0940-5429
1432-5233
DOI:10.1007/s005920200030