Successful use of combination antifungal therapy in the treatment of coccidioides meningitis

Coccidioidal meningitis is a highly lethal condition with a high morbidity and relapse rate caused by Coccidioides immitis. This case report highlights the difficulty in diagnosing and treating coccidioidal meningitis, and discusses a novel combination antifungal therapy (voriconazole and liposomal...

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Bibliographic Details
Published in:	Journal of the National Medical Association Vol. 98; no. 6; pp. 940 - 942
Main Authors:	ANTONY, Suresh J, JURCZYK, Peter, BRUMBLE, Lisa
Format:	Journal Article
Language:	English
Published:	Thorofare, NJ Slack 01-06-2006 Elsevier Limited National Medical Association
Subjects:	Adult Amphotericin B - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - therapeutic use Biological and medical sciences Coccidioides - drug effects Coccidioides - isolation & purification Coccidioidomycosis - diagnosis Coccidioidomycosis - drug therapy Diagnosis, Differential Drug Therapy, Combination General aspects Humans Male Medical sciences Meningitis, Fungal - diagnosis Meningitis, Fungal - drug therapy Pharmacology. Drug treatments Pyrimidines - therapeutic use Triazoles - therapeutic use Voriconazole treatment Nervous system diseases Drug combination Coccidioides immitis Use Phycomycetes Fungi Antifungal agent Central nervous system disease Tropical medicine Meningitis Combined treatment Thallophyta
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Summary:	Coccidioidal meningitis is a highly lethal condition with a high morbidity and relapse rate caused by Coccidioides immitis. This case report highlights the difficulty in diagnosing and treating coccidioidal meningitis, and discusses a novel combination antifungal therapy (voriconazole and liposomal amphotericin B), which was used to treat this patient.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0027-9684 1943-4693