Search Results - "JUNJI FUJIKURA"

Advancements in transplantation therapy for diabetes: Pancreas, islet and stem cell by Nakamura, Toshihiro, Fujikura, Junji, Inagaki, Nobuya

“…Pancreas transplantation and islet transplantation are now established in the treatment of IDDM. Several trials of stem cell‐derived cell transplantation…”
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Distinctive detection of insulinoma using [18F]FB(ePEG12)12-exendin-4 PET/CT by Murakami, Takaaki, Fujimoto, Hiroyuki, Hamamatsu, Keita, Yamauchi, Yuki, Kodama, Yuzo, Fujita, Naotaka, Fujikura, Junji, Shimizu, Yoichi, Nakamoto, Yuji, Kimura, Hiroyuki, Saji, Hideo, Inagaki, Nobuya

“…Specifying the exact localization of insulinoma remains challenging due to the lack of insulinoma-specific imaging methods. Recently, glucagon-like peptide-1…”
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Long‐term outcome of islet transplantation on insulin‐dependent diabetes mellitus: An observational cohort study by Nakamura, Toshihiro, Fujikura, Junji, Anazawa, Takayuki, Ito, Ryo, Ogura, Masahito, Okajima, Hideaki, Uemoto, Shinji, Inagaki, Nobuya

“…Aims/Introduction To investigate the long‐term efficacy and safety of islet transplantation (ITx) compared with multiple daily injections (MDI) or continuous…”
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Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model by Ito, Ryo, Kimura, Azuma, Hirose, Yurie, Hatano, Yu, Mima, Atsushi, Mae, Shin-Ichi, Keidai, Yamato, Nakamura, Toshihiro, Fujikura, Junji, Nishi, Yohei, Ohta, Akira, Toyoda, Taro, Inagaki, Nobuya, Osafune, Kenji

“…For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs to be improved…”
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A unique profile of insulin antibody titer in islet‐transplanted patients by Keidai, Yamato, Fujikura, Junji, Nakamura, Toshihiro, Anazawa, Takayuki, Ito, Ryo, Ogura, Masahito, Hatano, Etsuro, Inagaki, Nobuya

“…ABSTRACT Insulin antibodies (IAs) can cause glycemic variability. Islet transplantation (ITx) is a treatment for insulin‐deficient diabetes that aims to…”
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Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity by Sasaki, Akira, Yokote, Koutaro, Naitoh, Takeshi, Fujikura, Junji, Hayashi, Karin, Hirota, Yushi, Inagaki, Nobuya, Ishigaki, Yasushi, Kasama, Kazunori, Kikkawa, Eri, Koyama, Hidenori, Masuzaki, Hiroaki, Miyatsuka, Takeshi, Nozaki, Takehiro, Ogawa, Wataru, Ohta, Masayuki, Okazumi, Shinichi, Shimabukuro, Michio, Shimomura, Iichiro, Nishizawa, Hitoshi, Saiki, Atsuhito, Seki, Yosuke, Shojima, Nobuhiro, Tsujino, Motoyoshi, Ugi, Satoshi, Watada, Hiroaki, Yamauchi, Toshimasa, Yamaguchi, Takashi, Ueki, Kohjiro, Kadowaki, Takashi, Tatsuno, Ichiro

“…Bariatric surgery has been shown to have a variety of metabolically beneficial effects for patients with type 2 diabetes (T2D), and is now also called…”
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Circularity of islets is a distinct marker for the pathological diagnosis of adult non-neoplastic hyperinsulinemic hypoglycemia using surgical specimens by Nakagawa, Ryota, Minamiguchi, Sachiko, Kataoka, Tatsuki R, Fujikura, Junji, Masui, Toshihiko, Fujimoto, Masakazu, Yamada, Yosuke, Takeuchi, Yasuhide, Teramoto, Yuki, Ito, Hiroaki, Saka, Manduwa, Kitamura, Kyohei, Otsuki, Shinya, Nishijima, Ryohei, Haga, Hironori

“…Background Adult non-neoplastic hyperinsulinemic hypoglycemia (ANHH), also known as adult-onset nesidioblastosis, is a rare cause of endogenous…”
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Noninvasive evaluation of donor and native pancreases following simultaneous pancreas–kidney transplantation using positron emission tomography/computed tomography by Murakami, Takaaki, Nakamura, Toshihiro, Fujimoto, Hiroyuki, Fujikura, Junji, Shimizu, Yoichi, Miyake, Kanae K., Otani, Daisuke, Sakaki, Kentaro, Kiyobayashi, Sakura, Anazawa, Takayuki, Nakamoto, Yuji, Inagaki, Nobuya

“…ABSTRACT It is crucial to develop practical and noninvasive methods to assess the functional beta‐cell mass in a donor pancreas, in which monitoring and…”
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Reduced glycemic variability and flexible graft function after islet transplantation: A case report by Nakamura, Toshihiro, Fujikura, Junji, Anazawa, Takayuki, Ito, Ryo, Ogura, Masahito, Okajima, Hideaki, Noguchi, Hirofumi, Uemoto, Shinji, Inagaki, Nobuya

“…To date, studies of patients with islet transplantation addressing intermittently scanned continuous glucose monitoring profile and the flexibility of the…”
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Differentiation of embryonic stem cells is induced by GATA factors by Fujikura, Junji, Yamato, Eiji, Yonemura, Shigenobu, Hosoda, Kiminori, Masui, Shinji, Nakao, Kazuwa, Miyazaki Ji, Jun-ichi, Niwa, Hitoshi

“…Extraembryonic endoderm (ExE) is differentiated from the inner cell mass of the late blastocyst-stage embryo to form visceral and parietal endoderm, both of…”
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Adipose Tissue–Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy by Yasue, Shintaro, Masuzaki, Hiroaki, Okada, Sadanori, Ishii, Takako, Kozuka, Chisayo, Tanaka, Tomohiro, Fujikura, Junji, Ebihara, Ken, Hosoda, Kiminori, Katsurada, Akemi, Ohashi, Naro, Urushihara, Maki, Kobori, Hiroyuki, Morimoto, Naoki, Kawazoe, Takeshi, Naitoh, Motoko, Okada, Mitsuru, Sakaue, Hiroshi, Suzuki, Shigehiko, Nakao, Kazuwa

“…Background The adipose tissue renin–angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However,…”
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Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice by NAITO, Masaki, FUJIKURA, Junji, NAKAO, Kazuwa, EBIHARA, Ken, MIYANAGA, Fumiko, YOKOI, Hideki, KUSAKABE, Toru, YAMAMOTO, Yuji, SON, Cheol, MUKOYAMA, Masashi, HOSODA, Kiminori

“…The aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an…”
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Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte [Review] by Fujikura, Junji, Hosoda, Kiminori, Nakao, Kazuwa

“…Experimental transplantation of endocrine tissues has led to significant advances in our understanding of endocrinology and metabolism. Endocrine cell…”
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The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism by Tomita, Tsutomu, Hosoda, Kiminori, Fujikura, Junji, Inagaki, Nobuya, Nakao, Kazuwa

“…Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment…”
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Genetic and Pharmacological Inhibition of Rho-associated Kinase II Enhances Adipogenesis by Noguchi, Michio, Hosoda, Kiminori, Fujikura, Junji, Fujimoto, Muneya, Iwakura, Hiroshi, Tomita, Tsutomu, Ishii, Takako, Arai, Naoki, Hirata, Masakazu, Ebihara, Ken, Masuzaki, Hiroaki, Itoh, Hiroshi, Narumiya, Shuh, Nakao, Kazuwa

“…Rho-associated kinase (ROCK) regulates reorganization of actin cytoskeleton. During adipogenesis, the structure of filamentous actin is converted from long…”
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Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice by Kusakabe, Toru, Ebihara, Ken, Sakai, Takeru, Miyamoto, Licht, Aotani, Daisuke, Yamamoto, Yuji, Yamamoto-Kataoka, Sachiko, Aizawa-Abe, Megumi, Fujikura, Junji, Hosoda, Kiminori, Nakao, Kazuwa

“…Leptin enhances insulin sensitivity in addition to reducing food intake and body weight. Recently, amylin, a pancreatic β-cell-derived hormone, was shown to…”
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In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells by Noguchi, Michio, Hosoda, Kiminori, Nakane, Maiko, Mori, Eisaku, Nakao, Kazuhiro, Taura, Daisuke, Yamamoto, Yuji, Kusakabe, Toru, Sone, Masakatsu, Sakurai, Hidetoshi, Fujikura, Junji, Ebihara, Ken, Nakao, Kazuwa

“…Human induced pluripotent stem (iPS) and embryonic stem (ES) cells can differentiate into a variety of cell types. We reported on adipogenic potential of human…”
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Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1 by Miyazaki, Satsuki, Tashiro, Fumi, Fujikura, Junji, Yamato, Eiji, Miyazaki, Jun-ichi

“…Tubular complexes (TCs) are aggregates of duct-like monolayered cells in the developing and regenerating pancreas. Recent studies showed that TCs have…”
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Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas by Fujikura, Junji, Hosoda, Kiminori, Iwakura, Hiroshi, Tomita, Tsutomu, Noguchi, Michio, Masuzaki, Hiroaki, Tanigaki, Kenji, Yabe, Daisuke, Honjo, Tasuku, Nakao, Kazuwa

“…To investigate the precise role of Notch/Rbp-j signaling in the pancreas, we inactivated Rbp-j by crossing Rbp-j floxed mice with Pdx.cre or Rip.cre transgenic…”
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An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3‐L1 adipocytes by Fujimoto, Muneya, Masuzaki, Hiroaki, Tanaka, Tomohiro, Yasue, Shintaro, Tomita, Tsutomu, Okazawa, Kayoko, Fujikura, Junji, Chusho, Hideki, Ebihara, Ken, Hayashi, Tatsuya, Hosoda, Kiminori, Nakao, Kazuwa

“…Evidence has accumulated that some of the angiotensin II AT1 receptor antagonists have insulin‐sensitizing property. We thus examined the effect of telmisartan…”
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