Search Results - "JUNGBLUTH, Achim A"

PRAME Expression in Melanocytic Tumors by Lezcano, Cecilia, Jungbluth, Achim A, Nehal, Kishwer S, Hollmann, Travis J, Busam, Klaus J

“…PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While…”
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NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls by Solomon, James P., Linkov, Irina, Rosado, Andrea, Mullaney, Kerry, Rosen, Ezra Y., Frosina, Denise, Jungbluth, Achim A., Zehir, Ahmet, Benayed, Ryma, Drilon, Alexander, Hyman, David M., Ladanyi, Marc, Sireci, Anthony N., Hechtman, Jaclyn F.

“…With the FDA approval of larotrectinib, NTRK fusion assessment has recently become a standard part of management for patients with locally advanced or…”
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Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions by Hechtman, Jaclyn F, Benayed, Ryma, Hyman, David M, Drilon, Alexander, Zehir, Ahmet, Frosina, Denise, Arcila, Maria E, Dogan, Snjezana, Klimstra, David S, Ladanyi, Marc, Jungbluth, Achim A

“…Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain…”
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Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST by Prieto-Granada, Carlos N, Wiesner, Thomas, Messina, Jane L, Jungbluth, Achim A, Chi, Ping, Antonescu, Cristina R

“…Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes…”
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A Performance Comparison of Commonly Used Assays to Detect RET Fusions by Yang, Soo-Ryum, Aypar, Umut, Rosen, Ezra Y, Mata, Douglas A, Benayed, Ryma, Mullaney, Kerry, Jayakumaran, Gowtham, Zhang, Yanming, Frosina, Denise, Drilon, Alexander, Ladanyi, Marc, Jungbluth, Achim A, Rekhtman, Natasha, Hechtman, Jaclyn F

“…Selpercatinib and pralsetinib induce deep and durable responses in patients with advanced fusion-positive lung and thyroid cancer. fusion testing strategies…”
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Pan‐Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6–NTRK3 fusion by Xu, Bin, Haroon Al Rasheed, Mohamed R, Antonescu, Cristina R, Alex, Deepu, Frosina, Denise, Ghossein, Ronald, Jungbluth, Achim A, Katabi, Nora

“…Aims Secretory carcinoma (SC) of the salivary gland typically harbours ETV6–NTRK3 fusion, which can be utilised clinically to assist with diagnosis. Pan‐Trk…”
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Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing by Hensley, Martee L, Chavan, Shweta S, Solit, David B, Murali, Rajmohan, Soslow, Robert, Chiang, Sarah, Jungbluth, Achim A, Bandlamudi, Chaitanya, Srinivasan, Preethi, Tap, William D, Rosenbaum, Evan, Taylor, Barry S, Donoghue, Mark T A, Hyman, David M

“…We examined whether prospective molecular characterization of advanced metastatic disease can reveal grade and/or histology-specific differences to inform…”
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ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity by Lewis, Natasha, Soslow, Robert A, Delair, Deborah F, Park, Kay J, Murali, Rajmohan, Hollmann, Travis J, Davidson, Ben, Micci, Francesca, Panagopoulos, Ioannis, Hoang, Lien N, Arias-Stella, Javier A, Oliva, Esther, Young, Robert H, Hensley, Martee L, Leitao, Mario M, Hameed, Meera, Benayed, Ryma, Ladanyi, Marc, Frosina, Denise, Jungbluth, Achim A, Antonescu, Cristina R, Chiang, Sarah

“…High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE–NUTM2 fusion. Triggered by three…”
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Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients by Sabbatini, Paul, Tsuji, Takemasa, Ferran, Luis, Ritter, Erika, Sedrak, Christine, Tuballes, Kevin, Jungbluth, Achim A, Ritter, Gerd, Aghajanian, Carol, Bell-McGuinn, Katherine, Hensley, Martee L, Konner, Jason, Tew, William, Spriggs, David R, Hoffman, Eric W, Venhaus, Ralph, Pan, Linda, Salazar, Andres M, Diefenbach, Catherine Magid, Old, Lloyd J, Gnjatic, Sacha

“…Long peptides are efficiently presented to both CD4(+) and CD8(+) T cells after intracellular processing by antigen-presenting cells. To investigate the safety…”
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Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas by Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Kumar, Rahul, Brandes, Alissa, Fan, Dan, Basili, Thais, Da Cruz Paula, Arnaud, Lozada, John R., Blecua, Pedro, Muenst, Simone, Jungbluth, Achim A., Foschini, Maria P., Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K. Y., Norton, Larry, Varga, Zsuzsanna, Ellis, Ian O., Rakha, Emad A., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.

“…Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown…”
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The immune microenvironment and expression of PD‐L1, PD‐1, PRAME and MHC I in salivary duct carcinoma by Xu, Bin, Jungbluth, Achim A, Frosina, Denise, Alzumaili, Bayan, Aleynick, Nathaniel, Slodkowska, Elzbieta, Higgins, Kevin, Ho, Alan, Morris, Luc, Ghossein, Ronald, Katabi, Nora

“…Aims Salivary duct carcinoma (SDC) is an aggressive salivary malignancy that results in high mortality rates and is often resistant to chemotherapy…”
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Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets by Chen, Ying-Bei, Xu, Jianing, Skanderup, Anders Jacobsen, Dong, Yiyu, Brannon, A. Rose, Wang, Lu, Won, Helen H., Wang, Patricia I., Nanjangud, Gouri J., Jungbluth, Achim A., Li, Wei, Ojeda, Virginia, Hakimi, A. Ari, Voss, Martin H., Schultz, Nikolaus, Motzer, Robert J., Russo, Paul, Cheng, Emily H., Giancotti, Filippo G., Lee, William, Berger, Michael F., Tickoo, Satish K., Reuter, Victor E., Hsieh, James J.

“…Renal cell carcinomas with unclassified histology (uRCC) constitute a significant portion of aggressive non-clear cell renal cell carcinomas that have no…”
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BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology by Chiang, Sarah, Lee, Cheng-Han, Stewart, Colin J R, Oliva, Esther, Hoang, Lien N, Ali, Rola H, Hensley, Martee L, Arias-Stella, Javier A, Frosina, Denise, Jungbluth, Achim A, Benayed, Ryma, Ladanyi, Marc, Hameed, Meera, Wang, Lu, Kao, Yu-Chien, Antonescu, Cristina R, Soslow, Robert A

“…Recognition of high-grade endometrial stromal sarcoma is important because of its aggressive clinical behavior. Morphologic features of YWHAE-NUTM2 high-grade…”
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Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors by Pareja, Fresia, Brandes, Alissa H., Basili, Thais, Selenica, Pier, Geyer, Felipe C., Fan, Dan, Da Cruz Paula, Arnaud, Kumar, Rahul, Brown, David N., Gularte-Mérida, Rodrigo, Alemar, Barbara, Bi, Rui, Lim, Raymond S., de Bruijn, Ino, Fujisawa, Sho, Gardner, Rui, Feng, Elvin, Li, Anqi, da Silva, Edaise M., Lozada, John R., Blecua, Pedro, Cohen-Gould, Leona, Jungbluth, Achim A., Rakha, Emad A., Ellis, Ian O., Edelweiss, Maria I. A., Palazzo, Juan, Norton, Larry, Hollmann, Travis, Edelweiss, Marcia, Rubin, Brian P., Weigelt, Britta, Reis-Filho, Jorge S.

“…Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The…”
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Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type by Conlon, Niamh, Silva, Annacarolina, Guerra, Esther, Jelinic, Petar, Schlappe, Brooke A, Olvera, Narciso, Mueller, Jennifer J, Tornos, Carmen, Jungbluth, Achim A, Young, Robert H, Oliva, Esther, Levine, Douglas, Soslow, Robert A

“…Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare ovarian neoplasm that occurs in young women and has a poor prognosis. The histologic…”
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Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab by Yuan, Jianda, Adamow, Matthew, Ginsberg, Brian A, Rasalan, Teresa S, Ritter, Erika, Gallardo, Humilidad F, Xu, Yinyan, Pogoriler, Evelina, Terzulli, Stephanie L, Kuk, Deborah, Panageas, Katherine S, Ritter, Gerd, Sznol, Mario, Halaban, Ruth, Jungbluth, Achim A, Allison, James P, Old, Lloyd J, Wolchok, Jedd D, Gnjatic, Sacha

“…Ipilimumab, a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4), has been shown to improve survival in patients with advanced metastatic…”
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CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma by Sharma, Padmanee, Shen, Yu, Wen, Sijin, Yamada, Sachiko, Jungbluth, Achim A, Gnjatic, Sacha, Bajorin, Dean F, Reuter, Victor E, Herr, Harry, Old, Lloyd J, Sato, Eiichi

“…Tumor-infiltrating cytotoxic T lymphocytes (TILs), including CD8 TILs, have been associated with favorable clinical outcomes in multiple tumor types…”
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Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors by Arias-Stella, Javier A, Benayed, Ryma, Oliva, Esther, Young, Robert H, Hoang, Lien N, Lee, Cheng-Han, Jungbluth, Achim A, Frosina, Denise, Soslow, Robert A, Antonescu, Cristina R, Ladanyi, Marc, Chiang, Sarah

“…Genetic alterations in uterine myxoid leiomyosarcoma are unknown. We investigate the clinicopathologic features of 19 uterine tumors previously diagnosed as…”
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A genetic dichotomy between pure sclerosing epithelioid fibrosarcoma (SEF) and hybrid SEF/low-grade fibromyxoid sarcoma: A pathologic and molecular study of 18 cases by Prieto-Granada, Carlos, Zhang, Lei, Chen, Hsiao-Wei, Sung, Yun-Shao, Agaram, Narasimhan P, Jungbluth, Achim A, Antonescu, Cristina R

“…Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue tumor exhibiting considerable morphologic overlap with low‐grade fibromyxoid sarcoma (LGFMS)…”
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Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes and a High $CD8^+/regulatory$ T Cell Ratio Are Associated with Favorable Prognosis in Ovarian Cancer by Sato, Eiichi, Olson, Sara H., Jiyoung Ahn, Brian Bundy, Nishikawa, Hiroyoshi, Qian, Feng, Jungbluth, Achim A., Denise Frosina, Gnjatic, Sacha, Christine Ambrosone, Kepner, James, Tosin Odunsi, Ritter, Gerd, Shashikant Lele, Chen, Yao-Tseng, Haruo Ohtani, Old, Lloyd J., Odunsi, Kunle

“…In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348,203-213], the presence of CD3+ tumor-infiltrating lymphocytes (TILs) was found to correlate with…”
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