Search Results - "JUNEAU, P. L"

Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis by Bove, S.E, Calcaterra, S.L, Brooker, R.M, Huber, C.M, Guzman, R.E, Juneau, P.L, Schrier, D.J, Kilgore, K.S

“…Objective: To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of…”
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Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions by Loeffler, D A, Connor, J R, Juneau, P L, Snyder, B S, Kanaley, L, DeMaggio, A J, Nguyen, H, Brickman, C M, LeWitt, P A

“…Oxidant-mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion of hydrogen peroxide…”
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Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders by Loeffler, D.A., LeWitt, P.A., Juneau, P.L., Sima, A.A.F., Nguyen, H.-U., DeMaggio, A.J., Brickman, C.M., Brewer, G.J., Dick, R.D., Troyer, M.D., Kanaley, L.

“…Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional…”
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Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia by Bove, S.E., Laemont, K.D., Brooker, R.M., Osborn, M.N., Sanchez, B.M., Guzman, R.E., Hook, K.E., Juneau, P.L., Connor, J.R., Kilgore, K.S.

“…In the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA). OA was surgically induced in…”
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Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation by LOEFFLER, D. A, JUNEAU, P. L, MASSERANT, S

“…The proliferative response of murine lymphocytes to interleukin-2 (IL-2) was examined under physico-chemical conditions present in solid tumours, namely low…”
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Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells by Loeffler, D.A, Camp, D.M, Juneau, P.L, Harel, E, LeWitt, P.A

“…Studies with cerebrospinal fluid from subjects with Parkinson’s disease suggest that purine abnormalities may be present in this disorder. The effects of…”
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Cerebrospinal Fluid C3a Increases with Age, But Does Not Increase Further in Alzheimer’s Disease by Loeffler, D.A, Brickman, C.M, Juneau, P.L, Perry, M.F, Pomara, N, LeWitt, P.A

“…Complement activation is present in the brain in Alzheimer’s disease (AD), and C1q concentrations are decreased in AD cerebrospinal fluid (CSF). To determine…”
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Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation by Loeffler, D.A, LeWitt, P.A, Juneau, P.L, Camp, D.M, Arnold, L.A, Hyland, K

“…Levodopa treatment in Parkinson’s disease has been suggested to contribute to disease progression through free radical generation. We compared the time course…”
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Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease by Loeffler, D A, DeMaggio, A J, Juneau, P L, Brickman, C M, Mashour, G A, Finkelman, J H, Pomara, N, LeWitt, P A

“…Although the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) is unknown, altered brain antioxidative mechanisms have been found in…”
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Effects of enhanced striatal dopamine turnover in vivo on glutathione oxidation by Loeffler, D A, DeMaggio, A J, Juneau, P L, Havaich, M K, LeWitt, P A

“…In Parkinson's disease (PD), a compensatory increase in dopamine (DA) turnover occurs in the remaining nigrostriatal dopaminergic neurons, resulting in greater…”
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Altered Guanosine and Guanine Concentrations in Rabbit Striatum Following Increased Dopamine Turnover by Loeffler, D.A, LeWitt, P.A, Juneau, P.L, Camp, D.M, DeMaggio, A.J, Milbury, P, Matson, W.R, Rathbone, M.P

“…The significance of guanine nucleotides and nucleosides in neurodegenerative disorders is suggested by recent reports that these molecules enhance neurite…”
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Influence of repeated levodopa administration on rabbit striatal serotonin metabolism, and comparison between striatal and CSF alterations by LOEFFLER, D. A, LEWITT, P. A, JUNEAU, P. L, CAMP, D. M, DEMAGGIO, A. J, HAVAICH, M. K, MILBURY, P. E, MATSON, W. R

“…Parkinson's disease (PD) is characterized by decreased striatal dopamine, but serotonin (5-HT) is also reduced. Because 5-HT decreases following a single…”
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The novel use of vascular access ports for intravenous self-administration and blood withdrawal studies in squirrel monkeys by Kinsora Jr, J.J, Christoffersen, C.L, Swalec, J.M, Juneau, P.L

“…An important experimental challenge in research with squirrel monkeys (Saimiri scureus) is the development of a reliable closed intravenous system for long…”
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Brain extracellular levels of the putative antipsychotic CI-1007 and its effects on striatal and nucleus accumbens dopamine overflow in the awake rat by IYER, R. N, DAVIS, M. D, JUNEAU, P. L, GIORDANI, A. B

“…The compound CI-1007 (R-(+)-1,2,3,6-tetrahydro-4-phenyl-1 [(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine maleate) has been identified as a partial dopamine…”
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Immunocytochemical detection of anti-hippocampal antibodies in Alzheimer's disease and normal cerebrospinal fluid by LOEFFLER, D. A, JUNEAU, P. L, NGUYEN, H.-U, NAJMAN, D, POMARA, N, LEWITT, P. A

“…Immunocytochemical staining was performed to investigate the presence of anti-hippocampal antibodies in cerebrospinal fluid (CSF) from patients with probable…”
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Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats by Laemont, Keith D, Schaefer, Caralee J, Juneau, Paul L, Schrier, Denis J

“…The phosphodiesterase-IV (PDE-IV) inhibitor, rolipram, is antiinflammatory in a number of animal models and inhibits the release of a variety of cytokines,…”
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Markers of dopamine depletion and compensatory response in striatum and cerebrospinal fluid by LOEFFLER, D. A, LEWITT, P. A, DEMAGGIO, A. J, JUNEAU, P. L, MILBURY, P. E, MATSON, W. R

“…Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease…”
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Effects of Endothelin-Receptor Antagonism with PD156707 on Myocardial Stunning in Swine by McClanahan, Thomas B, Mertz, Thomas E, Ignasiak, Diane P, Juneau, Paul L, Gallagher, Kim P

“…SUMMARYEndothelin (ET) has been proposed to play a role in the pathogenesis of myocardial ischemia/reperfusion injury. The potential role of ET in myocardial…”
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Levodopa administration to normal rats: influence on striatal oxidized glutathione concentration by Loeffler, D A, Demaggio, A J, Juneau, P L, Havaich, M, Lewitt, P A

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Natural killer-cell activity under conditions reflective of tumor micro-environment by Loeffler, D A, Juneau, P L, Heppner, G H

“…Natural-killer(NK) activity was examined in the presence of low oxygen tension, low glucose concentration and acidic pH, to determine whether physical…”
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