Search Results - "JULIAS, John G"

Mutations in the RNase H Domain of HIV-1 Reverse Transcriptase Affect the Initiation of DNA Synthesis and the Specificity of RNase H Cleavage in vivo by Julias, John G., McWilliams, Mary Jane, Sarafianos, Stefan G., Arnold, Edward, Hughes, Stephen H.

“…Retroviral reverse transcriptases contain a DNA polymerase activity that can copy an RNA or DNA template and an RNase H activity that degrades the viral RNA…”
Get full text

Mutations in the U5 Region Adjacent to the Primer Binding Site Affect tRNA Cleavage by Human Immunodeficiency Virus Type 1 Reverse Transcriptase In Vivo by OH, Jangsuk, MCWILLIAMS, Mary Jane, JULIAS, John G, HUGHES, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases by Boyer, Paul L., Julias, John G., Marquez, Victor E., Hughes, Stephen H.

“…An important mechanism of resistance to nucleoside analogs is the enhanced excision of the analog after it has been incorporated. Excision requires that the…”
Get full text

Flexible use of nuclear import pathways by HIV-1 by Lee, KyeongEun, Ambrose, Zandrea, Martin, Thomas D, Oztop, Ilker, Mulky, Alok, Julias, John G, Vandegraaff, Nick, Baumann, Joerg G, Wang, Rui, Yuen, Wendy, Takemura, Taichiro, Shelton, Kenneth, Taniuchi, Ichiro, Li, Yuan, Sodroski, Joseph, Littman, Dan R, Coffin, John M, Hughes, Stephen H, Unutmaz, Derya, Engelman, Alan, KewalRamani, Vineet N

“…HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too…”
Get full text

Mutation of Amino Acids in the Connection Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Contact the Template-Primer Affects RNase H Activity by Julias, John G, McWilliams, Mary Jane, Sarafianos, Stefan G, Alvord, W Gregory, Arnold, Edward, Hughes, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control by Hodge, Deborah L., Martinez, Alfredo, Julias, John G., Taylor, Lynn S., Young, Howard A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Effects of Mutations in the G Tract of the Human Immunodeficiency Virus Type 1 Polypurine Tract on Virus Replication and RNase H Cleavage by JULIAS, John G, MCWILLIAMS, Mary Jane, SARAFIANOS, Stefan G, ALVORD, W. Gregory, ARNOLD, Eddy, HUGHES, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Level of Reverse Transcriptase (RT) in Human Immunodeficiency Virus Type 1 Particles Affects Susceptibility to Nonnucleoside RT Inhibitors but Not to Lamivudine by AMBROSE, Zandrea, JULIAS, John G, BOYER, Paul L, KEWALRAMANI, Vineet N, HUGHES, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis by Julias, John G, Boyer, Paul L, McWilliams, Mary Jane, Alvord, W.Gregory, Hughes, Stephen H

“…Methionine at position 184 of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) was changed to valine, isoleucine, threonine, or alanine…”
Get full text

Mutations in the 5′ End of the Human Immunodeficiency Virus Type 1 Polypurine Tract Affect RNase H Cleavage Specificity and Virus Titer by McWilliams, Mary Jane, Julias, John G, Sarafianos, Stefan G, Alvord, W Gregory, Arnold, Edward, Hughes, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Alternate Polypurine Tracts (PPTs) Affect the Rous Sarcoma Virus RNase H Cleavage Specificity and Reveal a Preferential Cleavage following a GA Dinucleotide Sequence at the PPT-U3 Junction by CHANG, Kevin W, JULIAS, John G, GREGORY ALVORD, W, OH, Jangsuk, HUGHES, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme by Morningstar, Marshall L, Roth, Thomas, Farnsworth, David W, Kroeger Smith, Marilyn, Watson, Karen, Buckheit, Robert W, Das, Kalyan, Zhang, Wanyi, Arnold, Eddy, Julias, John G, Hughes, Stephen H, Michejda, Christopher J

“…In an ongoing effort to develop novel and potent nonnucleoside HIV-1 reverse transcriptase (RT) inhibitors that are effective against the wild type (WT) virus…”
Get full text

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site by Himmel, Daniel M, Sarafianos, Stefan G, Dharmasena, Sanjeewa, Hossain, Mohammed M, McCoy-Simandle, Kessler, Ilina, Tatiana, Clark, Arthur D, Knight, Jennifer L, Julias, John G, Clark, Patrick K, Krogh-Jespersen, Karsten, Levy, Ronald M, Hughes, Stephen H, Parniak, Michael A, Arnold, Eddy

“…The rapid emergence of drug-resistant variants of human immunodeficiency virus, type 1 (HIV-1), has limited the efficacy of anti-acquired immune deficiency…”
Get full text

Construction and Characterization of a Replication-Competent Retroviral Shuttle Vector Plasmid by Oh, Jangsuk, Julias, John G, Ferris, Andrea L, Hughes, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Flexible Use of Nuclear Import Pathways by HIV-1 by Lee, KyeongEun, Ambrose, Zandrea, Martin, Thomas D., Oztop, Ilker, Mulky, Alok, Julias, John G., Vandegraaff, Nick, Baumann, Joerg G., Wang, Rui, Yuen, Wendy, Takemura, Taichiro, Shelton, Kenneth, Taniuchi, Ichiro, Li, Yuan, Sodroski, Joseph, Littman, Dan R., Coffin, John M., Hughes, Stephen H., Unutmaz, Derya, Engelman, Alan, KewalRamani, Vineet N.

Get full text

Replication of Phenotypically Mixed Human Immunodeficiency Virus Type 1 Virions Containing Catalytically Active and Catalytically Inactive Reverse Transcriptase by Julias, J G, Ferris, A L, Boyer, P L, Hughes, S H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Nucleoside Analogs 4′C-Methyl Thymidine and 4′C-Ethyl Thymidine Block DNA Synthesis by Wild-type HIV-1 RT and Excision Proficient NRTI Resistant RT Variants by Boyer, Paul L., Julias, John G., Ambrose, Zandrea, Siddiqui, Maqbool A., Marquez, Victor E., Hughes, Stephen H.

“…HIV-1 can become resistant to nucleoside analogs by developing an enhanced ability to excise the analogs after they have been incorporated. Excision requires…”
Get full text

The Nucleoside Analogue D-carba T Blocks HIV-1 Reverse Transcription by Boyer, Paul L, Vu, B. Christie, Ambrose, Zandrea, Julias, John G, Warnecke, Svenja, Liao, Chenzhong, Meier, Chris, Marquez, Victor E, Hughes, Stephen H

“…A major pathway for HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs) involves reverse transcriptase (RT) mutations that enhance…”
Get full text

Roles of viral and cellular proteins in the expression of alternatively spliced HTLV-1 pX mRNAs by Princler, Gerald L, Julias, John G, Hughes, Stephen H, Derse, David

“…The human T cell leukemia virus type 1 (HTLV-1) genome contains a cluster of at least five open reading frames (ORFs) near the 3′ terminus within the pX…”
Get full text

Deoxyribonucleoside Triphosphate Pool Imbalances In Vivo Are Associated with an Increased Retroviral Mutation Rate by Julias, J G, Pathak, V K

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text