Search Results - "JUDONG SHEN"

The support of human genetic evidence for approved drug indications by Nelson, Matthew R, Tipney, Hannah, Painter, Jeffery L, Shen, Judong, Nicoletti, Paola, Shen, Yufeng, Floratos, Aris, Sham, Pak Chung, Li, Mulin Jun, Wang, Junwen, Cardon, Lon R, Whittaker, John C, Sanseau, Philippe

“…Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene…”
Get full text

Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods by Zhai, Song, Zhang, Hong, Mehrotra, Devan V., Shen, Judong

“…Polygenic risk scores (PRS) have been successfully developed for the prediction of human diseases and complex traits in the past years. For drug response…”
Get full text

Multi-trait analysis of rare-variant association summary statistics using MTAR by Luo, Lan, Shen, Judong, Zhang, Hong, Chhibber, Aparna, Mehrotra, Devan V., Tang, Zheng-Zheng

“…Integrating association evidence across multiple traits can improve the power of gene discovery and reveal pleiotropy. Most multi-trait analysis methods focus…”
Get full text

Multi-population classical HLA type imputation by Dilthey, Alexander, Leslie, Stephen, Moutsianas, Loukas, Shen, Judong, Cox, Charles, Nelson, Matthew R, McVean, Gil

“…Statistical imputation of classical HLA alleles in case-control studies has become established as a valuable tool for identifying and fine-mapping signals of…”
Get full text

Integrating multiple traits for improving polygenic risk prediction in disease and pharmacogenomics GWAS by Zhai, Song, Guo, Bin, Wu, Baolin, Mehrotra, Devan V, Shen, Judong

“…Abstract Polygenic risk score (PRS) has been recently developed for predicting complex traits and drug responses. It remains unknown whether multi-trait PRS…”
Get full text

CauchyCP: A powerful test under non-proportional hazards using Cauchy combination of change-point Cox regressions by Zhang, Hong, Li, Qing, Mehrotra, Devan V, Shen, Judong

“…Non-proportional hazards data are routinely encountered in randomized clinical trials. In such cases, classic Cox proportional hazards model can suffer from…”
Get full text

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People by Nelson, Matthew R., Wegmann, Daniel, Ehm, Margaret G., Kessner, Darren, St. Jean, Pamela, Verzilli, Claudio, Shen, Judong, Tang, Zhengzheng, Bacanu, Silviu-Alin, Fraser, Dana, Warren, Liling, Aponte, Jennifer, Zawistowski, Matthew, Liu, Xiao, Zhang, Hao, Zhang, Yong, Li, Jun, Li, Yun, Li Li, Woollard, Peter, Topp, Simon, Hall, Matthew D., Nangle, Keith, Wang, Jun, Abecasis, Gonçalo, Cardon, Lon R., Zöllner, Sebastian, Whittaker, John C., Chissoe, Stephanie L., Novembre, John, Mooser, Vincent

“…Rare genetic variants contribute to complex disease risk; however, the abundance of rare variants in human populations remains unknown. We explored this…”
Get full text

Statistical assessment of biomarker replicability using MAJAR method by Xie, Yuhan, Zhai, Song, Jiang, Wei, Zhao, Hongyu, Mehrotra, Devan V, Shen, Judong

“…In the era of precision medicine, many biomarkers have been discovered to be associated with drug efficacy and safety responses, which can be used for patient…”
Get full text

No evidence of large genetic effects on steroid response in asthma patients by Mosteller, Michael, PhD, Hosking, Louise, BSc, Murphy, Kay, PhD, Shen, Judong, PhD, Song, Kijoung, PhD, Nelson, Matthew, PhD, Ghosh, Soumitra, PhD, MD

“…Background Inhaled corticosteroids (ICSs) are considered the most effective anti-inflammatory therapy for asthma control and management; however, there is…”
Get full text

A statistical perspective on baseline adjustment in pharmacogenomic genome-wide association studies of quantitative change by Zhang, Hong, Chhibber, Aparna, Shaw, Peter M., Mehrotra, Devan V., Shen, Judong

“…In pharmacogenetic (PGx) studies, drug response phenotypes are often measured in the form of change in a quantitative trait before and after treatment. There…”
Get full text

Genetic Association Reveals Protection against Recurrence of Clostridium difficile Infection with Bezlotoxumab Treatment by Shen, Judong, Mehrotra, Devan V, Dorr, Mary Beth, Zeng, Zhen, Li, Junhua, Xu, Xun, Nickle, David, Holzinger, Emily R, Chhibber, Aparna, Wilcox, Mark H, Blanchard, Rebecca L, Shaw, Peter M

“…Bezlotoxumab is a human monoclonal antibody against toxin B, indicated to prevent recurrence of infection (rCDI) in high-risk adults receiving antibacterial…”
Get full text

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation by WARREN, Liling L, LI LI, HALL, Matt D, TOPP, Simon D, XIN YUAN, CARDON, Lon R, CHISSOE, Stephanie L, MOOSER, Vincent, MORRIS, Andrew D, PALMER, Colin N. A, PERRY, John R, FRAYLING, Timothy M, NELSON, Matthew R, WHITTAKER, John C, WATERWORTH, Dawn M, EHM, Margaret G, JUDONG SHEN, FRASER, Dana J, APONTE, Jennifer L, NANGLE, Keith L, SLATER, Andrew J, WOOLLARD, Peter M

“…Increased adiponectin levels have been shown to be associated with a lower risk of type 2 diabetes. To understand the relations between genetic variation at…”
Get full text

Determination of cluster number in clustering microarray data by Shen, Judong, Chang, Shing I., Lee, E. Stanley, Deng, Youping, Brown, Susan J.

“…The general purpose of clustering analysis of microarray data is to organize the data into meaningful groups based on their closeness. Although various…”
Get full text

A Fast and Accurate Approximation to the Distributions of Quadratic Forms of Gaussian Variables by Zhang, Hong, Shen, Judong, Wu, Zheyang

“…In computational and applied statistics, it is of great interest to get fast and accurate calculation for the distributions of the quadratic forms of Gaussian…”
Get full text

Modelling and analysis of waviness reduction in soft-pad grinding of wire-sawn silicon wafers by support vector regression by Shen, Judong, Pei, Z. J., Fisher, G. R., Lee, E. S.

“…The manufacturing of silicon wafers forms the most important step in the construction of integrated circuit (IC) chips. One of the difficulties in this…”
Get full text

Robust genetic model-based SNP-set association test using CauchyGM by Kim, Yeonil, Chi, Yueh-Yun, Shen, Judong, Zou, Fei

“…Association testing on genome-wide association studies (GWAS) data is commonly performed under a single (mostly additive) genetic model framework. However, the…”
Get full text

AWOT and CWOT for genotype and genotype-by-treatment interaction joint analysis in pharmacogenetics GWAS by Zhang, Hong, Mehrotra, Devan V, Shen, Judong

“…Abstract Motivation Pharmacogenomics (PGx) research holds the promise for detecting association between genetic variants and drug responses in randomized…”
Get full text

Applying polygenic risk score methods to pharmacogenomics GWAS: challenges and opportunities by Zhai, Song, Mehrotra, Devan V, Shen, Judong

“…Polygenic risk scores (PRSs) have emerged as promising tools for the prediction of human diseases and complex traits in disease genome-wide association studies…”
Get full text

A fast and powerful linear mixed model approach for genotype-environment interaction tests in large-scale GWAS by Zhong, Wujuan, Chhibber, Aparna, Luo, Lan, Mehrotra, Devan V, Shen, Judong

“…Abstract Genotype-by-environment interaction (GEI or GxE) plays an important role in understanding complex human traits. However, it is usually challenging to…”
Get full text

Composite Kernel Association Test (CKAT) for SNP-set joint assessment of genotype and genotype-by-treatment interaction in Pharmacogenetics studies by Zhang, Hong, Zhao, Ni, Mehrotra, Devan V, Shen, Judong

“…Abstract Motivation It is of substantial interest to discover novel genetic markers that influence drug response in order to develop personalized treatment…”
Get full text