Search Results - "JUDAH, D. J"

Metabolism and toxicity of aflatoxins M1 and B1 in human-derived in vitro systems by NEAL, G. E, EATON, D. L, JUDAH, D. J, VERMA, A

“…Aflatoxin M1 (AFM1) is the principal hydroxylated aflatoxin metabolite present in the milk of dairy cows fed a diet contaminated with aflatoxin B1, (AFB1) and…”
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An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases by ELLIS, E. M, JUDAH, D. J, NEAL, G. E, HAYES, J. D

“…Protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1) can be achieved through the induction of detoxification enzymes by…”
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Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver by FORRESTER, L. M, NEAL, G. E, JUDAH, D. J, GLANCEY, M. J, WOLF, C. R

“…Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B1…”
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Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide by Hayes, J.D, Judah, D.J, McLellan, L.I, Kerr, L.A, Peacock, S.D, Neal, G.E

“…A purification scheme has been devised for two ethoxyquin-inducible Alpha-class glutathione S-transferases (GSTs) which possess at least 25-fold greater…”
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Differences in ethoxyquin nephrotoxicity between male and female F344 rats by Neal, G.E, Judah, D.J, Hard, G.G, Ito, N

“…Dose–response studies have shown a sharp threshold for the renal papillary toxic effect in male rats between 0.25% and 0.5% ethoxyquin (Eto) in the diet over 6…”
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Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide by HAYES, J. D, JUDAH, D. J, NEAL, G. E, NGUYEN, T

“…Resistance to the carcinogenic effects of aflatoxin B1 (AFB1) in the mouse is due to the constitutive expression of an Alpha-class glutathione S-transferase…”
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In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand by Kirby, G M, Wolf, C R, Neal, G E, Judah, D J, Henderson, C J, Srivatanakul, P, Wild, C P

“…Liver tissues were obtained from 20 liver cancer patients from Thailand, an area where the incidence of this tumour is high and where exposure to aflatoxin…”
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A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant by JUDAH, D. J, HAYES, J. D, YANG, J.-C, LIAN, L.-Y, ROBERTS, G. C. K, FARMER, P. B, LAMB, J. H, NEAL, G. E

“…In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at…”
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Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors by McLellan, L.I, Judah, D.J, Neal, G.E, Hayes, J.D

“…Ingestion of aflatoxin B1 (AFB,) represents a major risk factor in the etiology of human hepatocellular carcinoma. In the rat, the harmful effects of AFB1 can…”
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Mechanism of action of dietary chemoprotective agents in rat liver : induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism by MANSON, M. M, BALL, H. W. L, BARRETT, M. C, CLARK, H. L, JUDAH, D. J, WILLIAMSON, G, NEAL, G. E

“…A range of potential chemoprotective agents, most of them natural dietary constituents, has been examined for ability to modulate both phase I (cytochrome P450…”
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Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-Aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H :quinone oxidoreductase in rat liver by KELLY, V. P, ELLIS, E. M, MANSON, M. M, CHANAS, S. A, MOFFAT, G. J, MCLEOD, R, JUDAH, D. J, NEAL, G. E, HAYES, J. D

“…Structurally diverse compounds can confer resistance to aflatoxin B1 (AFB1) hepatocarcinogenesis in the rat. Treatment with either phytochemicals [benzyl…”
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Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1 by Hayes, J D, Judah, D J, McLellan, L I, Neal, G E

“…The harmful effects of Aflatoxin B1 (AFB1) are a consequence of it being metabolized to AFB1-8,9-epoxide, a compound that serves as an alkylating agent and…”
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Differences detected in vivo between samples of aflatoxin-contaminated peanut meal, following decontamination by two ammonia-based processes by Neal, G E, Judah, D J, Carthew, P, Verma, A, Latour, I, Weir, L, Coker, R D, Nagler, M J, Hoogenboom, L A

“…A sample of peanut meal, highly contaminated with aflatoxins, has been subjected to decontamination by two commercial ammonia-based processes. The original…”
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Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors by ELLIS, E. M, JUDAH, D. J, NEAL, G. E, O'CONNOR, T, HAYES, J. D

“…Feeding rats on diets containing the synthetic antioxidants ethoxyquin, butylated hydroxyanisole, and oltipraz results in 15-, 9-, and 6-fold increases,…”
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Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin by STANLEY, L. A, MANDEL, H. G, RILEY, J, SINHA, S, HIGGINSON, F. M, JUDAH, D. J, NEAL, G. E

“…Ingestion of aflatoxin B1 is implicated in the high incidence of human liver cancers in several developing countries. An association has been detected between…”
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Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance by TURTON, Nicola J, JUDAH, David J, RILEY, Joan, DAVIES, Reginald, LIPSON, Doron, STYLES, Jerry A, SMITH, Andrew G, GANT, Timothy W

“…The multidrug resistance (MDR) phenotype is a major cause of cancer treatment failure. Here the expressions of 4224 genes were analysed for association with…”
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Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver : predicting the outcome using early biomarkers by MANSON, M. M, HUDSON, E. A, BALL, H. W. L, BARRETT, M. C, CLARK, H. L, JUDAH, D. J, VERSCHOYLE, R. D, NEAL, G. E

“…Indole-3-carbinol (I3C) was examined for its ability to inhibit aflatoxin B1 (AFB1)-induced hepatocarcinogenesis in male Fischer rats when administered either…”
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Conjugation of model substrates or microsomally-activated aflatoxin B1 with reduced glutathione, catalysed by cytosolic glutathione-S-transferases in livers of rats, mice and guinea pigs by Neal, G E, Nielsch, U, Judah, D J, Hulbert, P B

“…Glutathione-S-transferase (GST) activity has been examined in liver cytosol fractions from guinea pigs, mice, control fed rats or rats with pre-neoplastic…”
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The primary and secondary metabolism of aflatoxin B1 by rat hepatocytes cultured on matrigel by Judah, D J, Davies, R, Hayes, J D, McLellan, L I, Neal, G E

“…Rat hepatocytes on culturing rapidly lose the ability to metabolize many xenobiotics including the mycotoxin aflatoxin B1 (AFB1). Rat hepatocytes cultured for…”
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Investigation of the assay of AFB1-albumin adducts using proteolysis products in ELISA by Olubuyide, I O, Makarananda, K, Judah, D J, Neal, G E

“…Epidemiological evidence of the involvement of aflatoxins in the aetiology of human liver cancer has led to an increasing interest in the development of…”
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