Search Results - "JS Hong"

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism by Block, Michelle L, Hong, Jau-Shyong

“…Inflammation, a common denominator among the diverse list of neurodegenerative diseases, has recently been implicated as a critical mechanism responsible for…”
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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin‐induced damage by Chen, SH, Wu, HM, Ossola, B, Schendzielorz, N, Wilson, BC, Chu, CH, Chen, SL, Wang, Q, Zhang, D, Qian, L, Li, X, Hong, JS, Lu, RB

“…BACKGROUND AND PURPOSE Prevention or disease‐modifying therapies are critical for the treatment of neurodegenerative disorders such as Alzheimer's disease,…”
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Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression by Gao, Hui-Ming, Hong, Jau-Shyong

“…Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous…”
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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms by Block, Michelle L, Zecca, Luigi, Hong, Jau-Shyong

“…Mounting evidence indicates that microglial activation contributes to neuronal damage in neurodegenerative diseases. Recent studies show that in response to…”
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Implications of prolonged expression of Fos-related antigens by Pennypacker, Keith R., Hong, Jau-S., McMillian, Michael K.

“…The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively…”
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Cystic fibrosis precision therapeutics: Emerging considerations by Joshi, Disha, Ehrhardt, Annette, Hong, Jeong S., Sorscher, Eric J.

“…Small molecules that address fundamental defects underlying cystic fibrosis (CF), including modulators such as the approved drugs ivacaftor, lumacaftor,…”
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Shell morphology and genetic characteristics of Corbula (Potamocorbula) spp. (Bivalvia: Corbulidae) from the waters adjacent to Japan, Korea and San Francisco Bay by M Owada, Y Kasai, S Sato, JS Hong

“…Corbula (Potamocorbula) spp. are natively distributed in the waters adjacent to Japan and Korea. These populations are distinguished by 6 morphological…”
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Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention by Liu, Bin, Hong, Jau-Shyong

“…Evidence from postmortem analysis implicates the involvement of microglia in the neurodegenerative process of several degenerative neurological diseases,…”
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The Distribution of Carbapenem-Resistant Acinetobacter Species and High Prevalence of CC92 OXA-23-Producing Acinetobacter Baumannii in Community Hospitals in South Korea by Bae, Il Kwon, Hong, Jun Sung

“…Clinical isolates of species in South Korea are continuously exhibiting high rates of antimicrobial resistance to carbapenems, indicating that there are public…”
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Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease by Zhang, Wei, Wang, Tongguang, Pei, Zhong, Miller, David S., Wu, Xuefei, Block, Michelle L., Wilson, Belinda, Zhang, Wanqin, Zhou, Yong, Hong, Jau-Shyong, Zhang, Jing

“…ABSTRACT A growing body of evidence indicates that an inflammatory process in the substantia nigra, characterized by activation of resident microglia, likely…”
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Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model by Jing, Lu, Hou, Liyan, Zhang, Dongdong, Li, Sheng, Ruan, Zhengzheng, Zhang, Xiaomeng, Hong, Jau-Shyong, Wang, Qingshan

“…Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear…”
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Novel anti-inflammatory therapy for Parkinson's disease by Gao, Hui-Ming, Liu, Bin, Zhang, Wangqin, Hong, Jau-Shyong

“…Parkinson's disease (PD) is a movement disorder that is characterized by progressive degeneration of the nigrostriatal dopamine system. Although dopamine…”
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Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons by Gao, Hui-Ming, Liu, Bin, Hong, Jau-Shyong

“…Increasing evidence has suggested an important role for environmental toxins such as pesticides in the pathogenesis of Parkinson's disease (PD). Chronic…”
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MR imaging assisted temperature calculations during cryosurgery by Hong, J S, Wong, S, Pease, G, Rubinsky, B

“…MRI has the potential of becoming an important imaging modality for monitoring the extent of the frozen region during cryosurgery. However, while the…”
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Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase by Block, M. L., Wu, X., Pei, Z., Li, G., Wang, T., Qin, L., Wilson, B., Yang, J., Hong, J. S., Veronesi, B.

“…ABSTRACT The contributing role of environmental factors to the development of Parkinson’s disease has become increasingly evident. We report that mesencephalic…”
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Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease by Gao, Hui‐Ming, Jiang, Janwei, Wilson, Belinda, Zhang, Wanqin, Hong, Jau‐Shyong, Liu, Bin

“…The etiology of sporadic Parkinson's disease (PD) remains unknown. Increasing evidence has suggested a role for inflammation in the brain in the pathogenesis…”
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Theory and experiment of dual-mode microstrip triangular patch resonators and filters by Hong, J.-S., Li, S.

“…In this paper, we report on the results of an investigation into dual-mode operation of microstrip triangular patch resonators and their applications for…”
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NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia by Qin, Liya, Liu, Yuxin, Wang, Tongguang, Wei, Sung-Jen, Block, Michelle L., Wilson, Belinda, Liu, Bin, Hong, Jau-Shyong

“…Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. We have previously reported that…”
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Critical role of microglial NADPH oxidase‐derived free radicals in the in vitro MPTP model of Parkinson's disease by Gao, Hui-Ming, Liu, Bin, Zhang, Wanqin, Hong, Jau-Shyong

“…1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) damages dopaminergic neurons as seen in Parkinson's disease. Although increasing evidence suggests an…”
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Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons by Gao, Hui-Ming, Hong, Jau-Shyong, Zhang, Wanqin, Liu, Bin

“…Increasing evidence has suggested an important role for environmental factors such as exposure to pesticides in the pathogenesis of Parkinson's disease. In…”
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