Search Results - "JR, J. B. HIBBS"

Nitric oxide: a cytotoxic activated macrophage effector molecule by Hibbs, Jr, J B, Taintor, R R, Vavrin, Z, Rachlin, E M

“…The experiments reported here identify nitric oxide as a molecular effector of activated macrophage induced cytotoxicity. Cytotoxic activated macrophages…”
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Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells by Amber, I J, Hibbs, Jr, J B, Taintor, R R, Vavrin, Z

“…Treatment of EMT-6 mammary adenocarcinoma cells with gamma interferon (rMuIFN gamma) plus tumor necrosis factor (rMuTNF alpha) and/or interleukin-1 (rHuIL-1…”
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EPR Demonstration of Iron-Nitrosyl Complex Formation by Cytotoxic Activated Macrophages by Lancaster, J. R., Hibbs, J. B.

“…Activated macrophage cytotoxicity is characterized by loss of intracellular iron and inhibition of certain enzymes that have catalyptically active nonheme-iron…”
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Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages by Drapier, J C, Wietzerbin, J, Hibbs, Jr, J B

“…We tested several monokines and muramyl dipeptide (MDP) to determine whether they induce the L-arginine-dependent effector mechanism in cultured murine…”
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Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite by Hibbs, John B., Taintor, Read R., Vavrin, Zdenek

“…Previous studies have shown that cytotoxic activated macrophages cause inhibition of DNA synthesis, of mitochondrial respiration, and of aconitase activity in…”
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Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages by GRANGER, D. L, HIBBS, J. B. JR, PERFECT, J. R, DURACK, D. T

“…L-arginine is required for the fungistatic action of murine macrophages in vitro. To further investigate this requirement, L-arginine metabolism by macrophages…”
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Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism by Green, SJ, Meltzer, MS, Hibbs, JB, Jr, Nacy, CA

“…Macrophages infected with amastigotes of Leishmania major and treated with IFN-gamma in vitro develop potent antimicrobial activities that eliminate the…”
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Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine by Adams, LB, Hibbs, JB, Jr, Taintor, RR, Krahenbuhl, JL

“…Recent studies show the importance of a single amino acid, L-arginine, as a necessary substrate for activated macrophage-mediated cytotoxic activity for tumor…”
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Nitric oxide produced during murine listeriosis is protective by BROOCKVAR, K. S, GRANGER, D. L, POSTON, R. M, MAYBODI, M, WASHINGTON, M. K, HIBBS, J. B, KURLANDER, R. L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells by Hibbs, JB, Jr, Vavrin, Z, Taintor, RR

“…L-Arginine is required for expression of the activated macrophage cytotoxic effector mechanism that causes inhibition of mitochondrial respiration, aconitase…”
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Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis by Evans, TG, Thai, L, Granger, DL, Hibbs, JB, Jr

“…In vitro experiments suggest that cytokine induced nitric oxide (NO) synthesis from L-arginine is a major effector mechanism against prokaryotic and eukaryotic…”
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The L-arginine dependent effector mechanism is induced in murine adenocarcinoma cells by culture supernatant from cytotoxic activated macrophages by Amber, I J, Hibbs, Jr, J B, Taintor, R R, Vavrin, Z

“…Culture medium conditioned by incubation with murine cytotoxic activated macrophages causes release of iron-55 label from viable murine EMT-6 tumor cells as…”
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Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets by N R Bastian, C Y Yim, J B Hibbs, Jr, W E Samlowski

“…The cell-mediated immune response to syngeneic tumors activates the cytokine-inducible nitric oxide synthase. We observed that syngeneic murine tumors…”
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Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2 by Yim, CY, Hibbs, JB, Jr, McGregor, JR, Galinsky, RE, Samlowski, WE

“…IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates. Glutathione, the major intracellular reductant, may become rate…”
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Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells by MAYER, J, WOODS, M. L, VAVRIN, Z, HIBBS, J. B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae by Adams, LB, Franzblau, SG, Vavrin, Z, Hibbs, JB, Jr, Krahenbuhl, JL

“…Recently, L-arginine has been shown to be a necessary substrate for murine-activated macrophage-mediated tumor cytostasis and microbiostasis of certain fungi,…”
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Nitric oxide synthesis contributes to IL-2-induced antitumor responses against intraperitoneal Meth A tumor by Yim, CY, McGregor, JR, Kwon, OD, Bastian, NR, Rees, M, Mori, M, Hibbs, JB, Jr, Samlowski, WE

“…IL-2 therapy is a potent inductive stimulus for nitric oxide (NO.) synthesis in mice and humans. It is not yet clear whether NO. can contribute to IL-2-induced…”
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Nitric oxide production during murine Lyme disease: lack of involvement in host resistance or pathology by SEILER, K. P, VAVRIN, Z, EICHWALD, E, HIBBS, J. B, WEIS, J. J

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells by Drapier, JC, Hibbs, JB, Jr

“…Previous studies show that cytotoxic activated macrophages cause a reproducible pattern of metabolic inhibition in viable tumor target cells. This includes…”
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Activated macrophage conditioned medium: identification of the soluble factors inducing cytotoxicity and the L-arginine dependent effector mechanism by Amber, I J, Hibbs, Jr, J B, Parker, C J, Johnson, B B, Taintor, R R, Vavrin, Z

“…Conditioned medium (CM) from cultures of cytotoxic activated macrophages causes inhibition of mitochondrial respiration, DNA synthesis, and aconitase activity…”
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