Search Results - "JOVE, R"

72 Targeting JAK-STAT Signaling for Cancer Therapy by Jove, R

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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival by Scuto, A, Krejci, P, Popplewell, L, Wu, J, Wang, Y, Kujawski, M, Kowolik, C, Xin, H, Chen, L, Kretzner, L, Yu, H, Wilcox, W R, Yen, Y, Forman, S, Jove, R

“…IL-6 and downstream JAK-dependent signaling pathways have critical roles in the pathophysiology of multiple myeloma (MM). We investigated the effects of a…”
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Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling by Lu, Jianming, Zhang, Keqiang, Nam, Sangkil, Anderson, Richard A., Jove, Richard, Wen, Wei

“…As a critical factor in the induction of angiogenesis, vascular endothelial growth factor (VEGF) has become an attractive target for anti-angiogenesis…”
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SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells by Scuto, A, Kirschbaum, M, Buettner, R, Kujawski, M, Cermak, J M, Atadja, P, Jove, R

“…We explored the activity of SIRT1 activators (SRT501 and SRT2183) alone and in combination with panobinostat in a panel of malignant lymphoid cell lines in…”
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Therapeutic potential of ruxolitinib in human ovarian cancer by Han, E.S, Dellinger, T, Wen, W, Wu, J, Jove, R, Horne, D, Yim, J.H

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miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis by Fu, X, Meng, Z, Liang, W, Tian, Y, Wang, X, Han, W, Lou, G, Lou, F, Yen, Y, Yu, H, Jove, R, Huang, W

“…Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway…”
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Evaluation of the laryngoscopy view using the modified Cormack-Lehane scale during tracheal intubation in an intensive care unit. A prospective observational study by Taboada, M, Soto-Jove, R, Mirón, P, Martínez, S, Rey, R, Ferreiroa, E, Almeida, X, Álvarez, J, Baluja, A

“…Tracheal intubation in the Intensive Care Unit is associated with a high incidence of difficult intubation and complications. This may be due to a poor view of…”
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Preface: STAT signaling by Jove, R

“…ONCOGENE: (2000) 19, 2466-2467…”
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Dynamic expression of Ralstonia solanacearum virulence factors and metabolism-controlling genes during plant infection by de Pedro-Jové, R, Puigvert, M, Sebastià, P, Macho, A P, Monteiro, J S, Coll, N S, Setúbal, J C, Valls, M

“…Ralstonia solanacearum is the causal agent of bacterial wilt, a devastating plant disease responsible for serious economic losses especially on potato, tomato,…”
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Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils by Epling-Burnette, P. K, Zhong, Bin, Bai, Fanqi, Jiang, Kun, Bailey, Ratna D, Garcia, Roy, Jove, Richard, Djeu, Julie Y, Loughran, Thomas P., Jr, Wei, Sheng

“…Polymorphonuclear neutrophils (PMN) are phagocytic cells constitutively programmed for apoptotic cell death. Exposure to GM-CSF delays apoptosis as measured by…”
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Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity by Zhang, Yi, Turkson, James, Carter-Su, Christin, Smithgall, Thomas, Levitzki, Alexander, Kraker, Alan, Krolewski, John J., Medveczky, Peter, Jove, Richard

“…Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors that transduce signals from the cell membrane to the…”
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Brightness temperature and emissivity retrieved from a portable L-band radiometer by Krishnan, Sooraj, Nair, Akhilesh S., Indu, J., Jove-Casulleras, R., Gonzalvez-Foguet, R.

“…L-band microwave radiometry is one of the globally accepted techniques to estimate surface soil moisture by measuring upwelling brightness temperature (TB)…”
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Drug resistance in multiple myeloma: approaches to circumvention by Dalton, W S, Jove, R

“…Resistance mechanisms to chemotherapy in multiple myeloma include (1) reduced drug concentrations at the target site of action, (2) alterations in the drug…”
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Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity by Sun, J, Blaskovich, M A, Jove, R, Livingston, S K, Coppola, D, Sebti, S M

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Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system by Stancato, L F, Chow, Y H, Hutchison, K A, Perdew, G H, Jove, R, Pratt, W B

“…Recently, we have demonstrated that the tyrosine kinase pp60v-src can undergo cell-free assembly into a heterocomplex with rabbit hsp90 and p50 when the…”
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Doctor, tengo Chikungunya». Sistematización conceptual de las implicaciones epidemiológicas específicas desde la medicina de familia by Turabián, J.L, Moreno-Ruiz, S, Cucho-Jove, R

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Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors by DORSEY, I. F, CUNNICK, J. M, LANEHART, R, HUANG, M, KRAKER, A. J, BHALLA, K. N, JOVE, R, WU, J

“…Bcr-Abl tyrosine kinase has been validated as a molecular target for the treatment of chronic myelogenous leukemia (CML). More recently, it has been reported…”
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Inhibition of JAK Kinase Activity Enhances Fas-mediated Apoptosis but Reduces Cytotoxic Activity of Topoisomerase II Inhibitors in U266 Myeloma Cells by OSHIRO, Marc M, LANDOWSKI, Terry H, CATLETT-FALCONE, Robyn, HAZLEHURST, Lori A, MEI HUANG, JOVE, Richard, DALTON, William S

“…Our previous work demonstrated that the Janus kinase (JAK)-Stat3 pathway regulates expression of Bcl-x L in the U266 human multiple myeloma cell line and…”
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The STATs of cancer - new molecular targets come of age by Yu, Hua, Jove, Richard

“…Key Points Signal transducer and activator of transcription (STAT)-family proteins are latent cytoplasmic transcription factors that convey signals from…”
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Multicentric comparative study: Mortality and morbidity in C2 fractures in the elderly according to the type of treatment performed by Anglada, N., Solé, P., Pellejero, R., Mas, J., Abad, R., Grau, A., Peroy, J.L., Jové, R.

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